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Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea.
Am J Epidemiol. 2011 Sep 01; 174(5):552-62.AJ

Abstract

The associations between alcohol consumption and cigarette smoking habits and the risk for colorectal adenomatous polyps according to the detailed clinical information about polyps were assessed in a large colonoscopy-based study. The study enrolled participants who visited the National Cancer Center of the Republic of Korea for cancer screening between April 2007 and April 2009. In 1,242 newly diagnosed colorectal adenoma patients and 3,019 polyp-free controls, past smokers (odds ratio (OR) = 1.31, 95% confidence interval (CI): 1.04, 1.65) and current smokers (OR = 1.70, 95% CI: 1.37, 2.11) had increased risks for adenomas compared with nonsmokers. Cigarette smoking conferred an even higher risk for advanced adenomas and 3 or more adenomas than for low-risk adenomas or a single adenoma. Dose-response relations were observed among the daily number of cigarettes smoked, the duration of smoking, the pack-years of smoking, and the risk for adenomas. A longer duration of alcohol consumption was associated with a higher risk for advanced adenomas (for >28 years of consumption: OR = 2.0, 95% CI: 1.10, 3.64) and 3 or more adenomas (OR = 2.19, 95% CI: 1.27, 3.76). In conclusion, cigarette smoking and alcohol consumption play roles in colorectal carcinogenesis, and the association differs by the clinical features of the adenomas.

Authors+Show Affiliations

Colorectal Cancer Branch, National Cancer Center Hospital, 323 Ilsanro Ilsandong-gu, Goyang-si, Geyonggi-do 410-769, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21791710

Citation

Shin, Aesun, et al. "Associations of Cigarette Smoking and Alcohol Consumption With Advanced or Multiple Colorectal Adenoma Risks: a Colonoscopy-based Case-control Study in Korea." American Journal of Epidemiology, vol. 174, no. 5, 2011, pp. 552-62.
Shin A, Hong CW, Sohn DK, et al. Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea. Am J Epidemiol. 2011;174(5):552-62.
Shin, A., Hong, C. W., Sohn, D. K., Chang Kim, B., Han, K. S., Chang, H. J., Kim, J., & Oh, J. H. (2011). Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea. American Journal of Epidemiology, 174(5), 552-62. https://doi.org/10.1093/aje/kwr098
Shin A, et al. Associations of Cigarette Smoking and Alcohol Consumption With Advanced or Multiple Colorectal Adenoma Risks: a Colonoscopy-based Case-control Study in Korea. Am J Epidemiol. 2011 Sep 1;174(5):552-62. PubMed PMID: 21791710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea. AU - Shin,Aesun, AU - Hong,Chang Won, AU - Sohn,Dae Kyung, AU - Chang Kim,Byung, AU - Han,Kyung Su, AU - Chang,Hee Jin, AU - Kim,Jeongseon, AU - Oh,Jae Hwan, Y1 - 2011/07/26/ PY - 2011/7/28/entrez PY - 2011/7/28/pubmed PY - 2011/10/18/medline SP - 552 EP - 62 JF - American journal of epidemiology JO - Am J Epidemiol VL - 174 IS - 5 N2 - The associations between alcohol consumption and cigarette smoking habits and the risk for colorectal adenomatous polyps according to the detailed clinical information about polyps were assessed in a large colonoscopy-based study. The study enrolled participants who visited the National Cancer Center of the Republic of Korea for cancer screening between April 2007 and April 2009. In 1,242 newly diagnosed colorectal adenoma patients and 3,019 polyp-free controls, past smokers (odds ratio (OR) = 1.31, 95% confidence interval (CI): 1.04, 1.65) and current smokers (OR = 1.70, 95% CI: 1.37, 2.11) had increased risks for adenomas compared with nonsmokers. Cigarette smoking conferred an even higher risk for advanced adenomas and 3 or more adenomas than for low-risk adenomas or a single adenoma. Dose-response relations were observed among the daily number of cigarettes smoked, the duration of smoking, the pack-years of smoking, and the risk for adenomas. A longer duration of alcohol consumption was associated with a higher risk for advanced adenomas (for >28 years of consumption: OR = 2.0, 95% CI: 1.10, 3.64) and 3 or more adenomas (OR = 2.19, 95% CI: 1.27, 3.76). In conclusion, cigarette smoking and alcohol consumption play roles in colorectal carcinogenesis, and the association differs by the clinical features of the adenomas. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/21791710/Associations_of_cigarette_smoking_and_alcohol_consumption_with_advanced_or_multiple_colorectal_adenoma_risks:_a_colonoscopy_based_case_control_study_in_Korea_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwr098 DB - PRIME DP - Unbound Medicine ER -