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Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects.
Eur J Clin Nutr 2012; 66(1):32-8EJ

Abstract

BACKGROUND/OBJECTIVES

Postprandial lipaemia is an established risk factor for atherosclerosis. To investigate the acute effect of four milk-derived dietary proteins (alpha-lactalbumin, whey isolate, caseinoglycomacropeptide and whey hydrolysate) on postprandial lipaemia, we have conducted a randomized, acute, single-blinded clinical intervention study with crossover design.

SUBJECTS/METHODS

A total of 11 obese non-diabetic subjects (age: 44-74, BMI: 30-41.4 kg m(-2)) were included. On 4 different days the subjects ingested a high-fat meal with the following energy distribution: 66% energy from fat (100 g of butter), 15% of energy from carbohydrate (90 g of white wheat bread) and 19% of energy from protein (45 g of pure protein). Our primary variable was plasma triglyceride measured in the 8-h postprandial period. Secondarily, retinyl palmitate, non-esterified free fatty acids, glucose, insulin, glucagon, GLP-1 and GIP, active and total grehlin and cholecystokinin were measured.

RESULTS

We observed no statistically significant (P=0.8) differences between meals on our primary variable that is, triglycerides. Whey hydrolysate was associated with a significantly (P=0.02) smaller postprandial suppression of non-esterified free fatty acids compared with the other dietary proteins.

CONCLUSION

We did not observe significant differences in postprandial lipaemia to the four milk-derived dietary proteins. Whey hydrolysate caused less postprandial suppression of free fatty acids.

Authors+Show Affiliations

Department of Endocrinology and Metabolism MEA, Aarhus University Hospital, Aarhus, Denmark. holmer-jensen@ki.au.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21792215

Citation

Holmer-Jensen, J, et al. "Acute Differential Effects of Milk-derived Dietary Proteins On Postprandial Lipaemia in Obese Non-diabetic Subjects." European Journal of Clinical Nutrition, vol. 66, no. 1, 2012, pp. 32-8.
Holmer-Jensen J, Hartvigsen ML, Mortensen LS, et al. Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects. Eur J Clin Nutr. 2012;66(1):32-8.
Holmer-Jensen, J., Hartvigsen, M. L., Mortensen, L. S., Astrup, A., de Vrese, M., Holst, J. J., ... Hermansen, K. (2012). Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects. European Journal of Clinical Nutrition, 66(1), pp. 32-8. doi:10.1038/ejcn.2011.142.
Holmer-Jensen J, et al. Acute Differential Effects of Milk-derived Dietary Proteins On Postprandial Lipaemia in Obese Non-diabetic Subjects. Eur J Clin Nutr. 2012;66(1):32-8. PubMed PMID: 21792215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects. AU - Holmer-Jensen,J, AU - Hartvigsen,M L, AU - Mortensen,L S, AU - Astrup,A, AU - de Vrese,M, AU - Holst,J J, AU - Thomsen,C, AU - Hermansen,K, Y1 - 2011/07/27/ PY - 2011/7/28/entrez PY - 2011/7/28/pubmed PY - 2012/5/23/medline SP - 32 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 66 IS - 1 N2 - BACKGROUND/OBJECTIVES: Postprandial lipaemia is an established risk factor for atherosclerosis. To investigate the acute effect of four milk-derived dietary proteins (alpha-lactalbumin, whey isolate, caseinoglycomacropeptide and whey hydrolysate) on postprandial lipaemia, we have conducted a randomized, acute, single-blinded clinical intervention study with crossover design. SUBJECTS/METHODS: A total of 11 obese non-diabetic subjects (age: 44-74, BMI: 30-41.4 kg m(-2)) were included. On 4 different days the subjects ingested a high-fat meal with the following energy distribution: 66% energy from fat (100 g of butter), 15% of energy from carbohydrate (90 g of white wheat bread) and 19% of energy from protein (45 g of pure protein). Our primary variable was plasma triglyceride measured in the 8-h postprandial period. Secondarily, retinyl palmitate, non-esterified free fatty acids, glucose, insulin, glucagon, GLP-1 and GIP, active and total grehlin and cholecystokinin were measured. RESULTS: We observed no statistically significant (P=0.8) differences between meals on our primary variable that is, triglycerides. Whey hydrolysate was associated with a significantly (P=0.02) smaller postprandial suppression of non-esterified free fatty acids compared with the other dietary proteins. CONCLUSION: We did not observe significant differences in postprandial lipaemia to the four milk-derived dietary proteins. Whey hydrolysate caused less postprandial suppression of free fatty acids. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/21792215/Acute_differential_effects_of_milk_derived_dietary_proteins_on_postprandial_lipaemia_in_obese_non_diabetic_subjects_ L2 - http://dx.doi.org/10.1038/ejcn.2011.142 DB - PRIME DP - Unbound Medicine ER -