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Plasma fatty acid composition in continuous ambulatory peritoneal dialysis patients: an increased omega-6/omega-3 ratio and deficiency of essential fatty acids.
Ren Fail. 2011; 33(8):819-23.RF

Abstract

Patients with end-stage renal disease, including those treated with peritoneal dialysis, have a high risk for death, particularly from cardiovascular causes. Plasma fatty acid (FA) composition is used as an indicator of disease risk, because its alteration has been related to metabolic disease and cardiovascular disease. For this purpose, we have measured plasma FA composition in continuous ambulatory peritoneal dialysis (CAPD) patients and compared them with those of healthy subjects. This study was performed on 51 (21 M, 30 F) CAPD patients at least 6 months under dialysis, aged 20-75 years (mean 47.81 ± 11.8 years) and 45 (25 M, 20 F) healthy control subjects aged 20-60 years (mean 38.62 ± 12.9 years). Plasma 10-cis-pentadecanoic acid, 10-cis-heptadecanoic acid, heneicosanoic acid, tricosanoic acid, nervonic acid, saturated fatty acid, and monounsaturated FA levels and delta 9 desaturase activity were significantly higher whereas linoleic acid, linolenic acid, 11,14-eicosedienoic acid, arachidonic acid, docosahexaenoic acid, and omega-3 FA levels were significantly lower in the CAPD group than those in the healthy group. Our results show that there are FA abnormalities and especially a depletion in essential FA levels and a high level of omega-6/omega-3 ratio in CAPD patients, the underlying mechanism of which is not known and needs to be investigated. Therefore, we believe that essential FA supplementation should be encouraged for CAPD patients.

Authors+Show Affiliations

Department of Biochemistry, Meram Faculty of Medicine, University of Selcuk, Konya, Turkey. fhumeyray@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21793790

Citation

Yerlikaya, Fatma Hümeyra, et al. "Plasma Fatty Acid Composition in Continuous Ambulatory Peritoneal Dialysis Patients: an Increased Omega-6/omega-3 Ratio and Deficiency of Essential Fatty Acids." Renal Failure, vol. 33, no. 8, 2011, pp. 819-23.
Yerlikaya FH, Mehmetoglu I, Kurban S, et al. Plasma fatty acid composition in continuous ambulatory peritoneal dialysis patients: an increased omega-6/omega-3 ratio and deficiency of essential fatty acids. Ren Fail. 2011;33(8):819-23.
Yerlikaya, F. H., Mehmetoglu, I., Kurban, S., & Tonbul, Z. (2011). Plasma fatty acid composition in continuous ambulatory peritoneal dialysis patients: an increased omega-6/omega-3 ratio and deficiency of essential fatty acids. Renal Failure, 33(8), 819-23. https://doi.org/10.3109/0886022X.2011.601831
Yerlikaya FH, et al. Plasma Fatty Acid Composition in Continuous Ambulatory Peritoneal Dialysis Patients: an Increased Omega-6/omega-3 Ratio and Deficiency of Essential Fatty Acids. Ren Fail. 2011;33(8):819-23. PubMed PMID: 21793790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma fatty acid composition in continuous ambulatory peritoneal dialysis patients: an increased omega-6/omega-3 ratio and deficiency of essential fatty acids. AU - Yerlikaya,Fatma Hümeyra, AU - Mehmetoglu,Idris, AU - Kurban,Sevil, AU - Tonbul,Zeki, Y1 - 2011/07/28/ PY - 2011/7/29/entrez PY - 2011/7/29/pubmed PY - 2012/1/11/medline SP - 819 EP - 23 JF - Renal failure JO - Ren Fail VL - 33 IS - 8 N2 - Patients with end-stage renal disease, including those treated with peritoneal dialysis, have a high risk for death, particularly from cardiovascular causes. Plasma fatty acid (FA) composition is used as an indicator of disease risk, because its alteration has been related to metabolic disease and cardiovascular disease. For this purpose, we have measured plasma FA composition in continuous ambulatory peritoneal dialysis (CAPD) patients and compared them with those of healthy subjects. This study was performed on 51 (21 M, 30 F) CAPD patients at least 6 months under dialysis, aged 20-75 years (mean 47.81 ± 11.8 years) and 45 (25 M, 20 F) healthy control subjects aged 20-60 years (mean 38.62 ± 12.9 years). Plasma 10-cis-pentadecanoic acid, 10-cis-heptadecanoic acid, heneicosanoic acid, tricosanoic acid, nervonic acid, saturated fatty acid, and monounsaturated FA levels and delta 9 desaturase activity were significantly higher whereas linoleic acid, linolenic acid, 11,14-eicosedienoic acid, arachidonic acid, docosahexaenoic acid, and omega-3 FA levels were significantly lower in the CAPD group than those in the healthy group. Our results show that there are FA abnormalities and especially a depletion in essential FA levels and a high level of omega-6/omega-3 ratio in CAPD patients, the underlying mechanism of which is not known and needs to be investigated. Therefore, we believe that essential FA supplementation should be encouraged for CAPD patients. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/21793790/Plasma_fatty_acid_composition_in_continuous_ambulatory_peritoneal_dialysis_patients:_an_increased_omega_6/omega_3_ratio_and_deficiency_of_essential_fatty_acids_ L2 - https://www.tandfonline.com/doi/full/10.3109/0886022X.2011.601831 DB - PRIME DP - Unbound Medicine ER -