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Formulation and evaluation of reconstitutable suspensions containing ibuprofen-loaded Eudragit microspheres.
Acta Pol Pharm. 2011 Jul-Aug; 68(4):593-9.AP

Abstract

The objective of this work was to develop and evaluate reconstitutable suspensions of ibuprofen-loaded microspheres prepared with an acrylic polymer (Eudragit RS-PM). The microspheres were prepared by the quasi-emulsion solvent diffusion technique. To prepare reconstitutable suspension formulation, the microspheres used had a mean particle size of 316.6 microm and 99.8% loading efficiency. Xanthan gum was chosen as the suspending agent for the suspension formulations. D-sorbitol was used to impart palatability of suspensions. The amount of D-sorbitol affected sedimentation volume and redispersibility properties of suspensions. The highest improving effect was shown with 20.0% and 25.0% of D-sorbitol concentrations. It was observed that dispersion media of suspensions showed non-Newtonian flow characteristics. To ensure minimum drug leakage from the microspheres into the suspension, the pH was buffered at 3.60 using citrate buffer. The ibuprofen content calculated from the suspended microspheres was consistent with that from microspheres alone. This result indicated that no leakage of drug occurred from the microspheres in the suspension on storage. Moreover, the same release rate of ibuprofen from the microspheres suspension and microspheres alone indicated that the suspension medium studied did not affect the property of drug release. This study suggested that stable suspensions of ibuprofen-loaded microspheres could be formulated with 0.6% w/v xanthan gum by the addition of 20% w/v D-sorbitol.

Authors+Show Affiliations

Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100-Tandoğan, Ankara, Turkey. bdevrim@pharmacy.ankara.edu.trNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

21796942

Citation

Devrim, Burcu, et al. "Formulation and Evaluation of Reconstitutable Suspensions Containing Ibuprofen-loaded Eudragit Microspheres." Acta Poloniae Pharmaceutica, vol. 68, no. 4, 2011, pp. 593-9.
Devrim B, Bozkir A, Canefe K. Formulation and evaluation of reconstitutable suspensions containing ibuprofen-loaded Eudragit microspheres. Acta Pol Pharm. 2011;68(4):593-9.
Devrim, B., Bozkir, A., & Canefe, K. (2011). Formulation and evaluation of reconstitutable suspensions containing ibuprofen-loaded Eudragit microspheres. Acta Poloniae Pharmaceutica, 68(4), 593-9.
Devrim B, Bozkir A, Canefe K. Formulation and Evaluation of Reconstitutable Suspensions Containing Ibuprofen-loaded Eudragit Microspheres. Acta Pol Pharm. 2011 Jul-Aug;68(4):593-9. PubMed PMID: 21796942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and evaluation of reconstitutable suspensions containing ibuprofen-loaded Eudragit microspheres. AU - Devrim,Burcu, AU - Bozkir,Asuman, AU - Canefe,Kandemir, PY - 2011/7/30/entrez PY - 2011/7/30/pubmed PY - 2011/8/19/medline SP - 593 EP - 9 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 68 IS - 4 N2 - The objective of this work was to develop and evaluate reconstitutable suspensions of ibuprofen-loaded microspheres prepared with an acrylic polymer (Eudragit RS-PM). The microspheres were prepared by the quasi-emulsion solvent diffusion technique. To prepare reconstitutable suspension formulation, the microspheres used had a mean particle size of 316.6 microm and 99.8% loading efficiency. Xanthan gum was chosen as the suspending agent for the suspension formulations. D-sorbitol was used to impart palatability of suspensions. The amount of D-sorbitol affected sedimentation volume and redispersibility properties of suspensions. The highest improving effect was shown with 20.0% and 25.0% of D-sorbitol concentrations. It was observed that dispersion media of suspensions showed non-Newtonian flow characteristics. To ensure minimum drug leakage from the microspheres into the suspension, the pH was buffered at 3.60 using citrate buffer. The ibuprofen content calculated from the suspended microspheres was consistent with that from microspheres alone. This result indicated that no leakage of drug occurred from the microspheres in the suspension on storage. Moreover, the same release rate of ibuprofen from the microspheres suspension and microspheres alone indicated that the suspension medium studied did not affect the property of drug release. This study suggested that stable suspensions of ibuprofen-loaded microspheres could be formulated with 0.6% w/v xanthan gum by the addition of 20% w/v D-sorbitol. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/21796942/Formulation_and_evaluation_of_reconstitutable_suspensions_containing_ibuprofen_loaded_Eudragit_microspheres_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2011/4/593.pdf DB - PRIME DP - Unbound Medicine ER -