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Formulation development of carvedilol compression coated tablet.
Pharm Dev Technol. 2013 Jul-Aug; 18(4):906-15.PD

Abstract

PURPOSE

The aim of present research was to produce carvedilol compression coated tablet to provide biphasic drug release.

METHOD

A compressed coated tablet made of a sustained release core tablet and an immediate release coat tablet. Both the core and the coat contained carvedilol. The sustained release effect was achieved with polymers (HPMC K4M and PEO WSR 205) to modulate the release of the drug. The powder blends for core and coat tablets were evaluated for angle of repose, bulk density, compressibility index, and drug content. Compressed coated tablets were evaluated for thickness, diameter, weight variation test, drug content, hardness, friability, disintegration and in vitro release studies.

RESULT

The powder blends showed satisfactory flow properties, compressibility, drug content and all the tablet formulations showed acceptable pharmaco-technical properties. Carvedilol contained in the fast releasing component was released within 3 min, whereas the drug in the core tablet was released at different times up to 24 h, depending on the composition of the matrix tablet. The mechanism of drug release was fickian diffusion or anomalous behavior.

DISCUSSION

Batch F7, containing 10 mg PEO WSR 205 and 5 mg HPMC K4M, showed maximum similarity with theoretical profile and zero order drug release kinetic.

Authors+Show Affiliations

Maliba Pharmacy College, Pharmaceutics, Bardoli Mahuva road, Tarsadi, Surat, India. ritesh_shah7@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21797662

Citation

Shah, Ritesh, et al. "Formulation Development of Carvedilol Compression Coated Tablet." Pharmaceutical Development and Technology, vol. 18, no. 4, 2013, pp. 906-15.
Shah R, Patel S, Patel H, et al. Formulation development of carvedilol compression coated tablet. Pharm Dev Technol. 2013;18(4):906-15.
Shah, R., Patel, S., Patel, H., Pandey, S., Shah, S., & Shah, D. (2013). Formulation development of carvedilol compression coated tablet. Pharmaceutical Development and Technology, 18(4), 906-15. https://doi.org/10.3109/10837450.2011.598167
Shah R, et al. Formulation Development of Carvedilol Compression Coated Tablet. Pharm Dev Technol. 2013 Jul-Aug;18(4):906-15. PubMed PMID: 21797662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation development of carvedilol compression coated tablet. AU - Shah,Ritesh, AU - Patel,Sachin, AU - Patel,Hetal, AU - Pandey,Sonia, AU - Shah,Shailesh, AU - Shah,Dinesh, Y1 - 2011/07/28/ PY - 2011/7/30/entrez PY - 2011/7/30/pubmed PY - 2013/12/24/medline SP - 906 EP - 15 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 18 IS - 4 N2 - PURPOSE: The aim of present research was to produce carvedilol compression coated tablet to provide biphasic drug release. METHOD: A compressed coated tablet made of a sustained release core tablet and an immediate release coat tablet. Both the core and the coat contained carvedilol. The sustained release effect was achieved with polymers (HPMC K4M and PEO WSR 205) to modulate the release of the drug. The powder blends for core and coat tablets were evaluated for angle of repose, bulk density, compressibility index, and drug content. Compressed coated tablets were evaluated for thickness, diameter, weight variation test, drug content, hardness, friability, disintegration and in vitro release studies. RESULT: The powder blends showed satisfactory flow properties, compressibility, drug content and all the tablet formulations showed acceptable pharmaco-technical properties. Carvedilol contained in the fast releasing component was released within 3 min, whereas the drug in the core tablet was released at different times up to 24 h, depending on the composition of the matrix tablet. The mechanism of drug release was fickian diffusion or anomalous behavior. DISCUSSION: Batch F7, containing 10 mg PEO WSR 205 and 5 mg HPMC K4M, showed maximum similarity with theoretical profile and zero order drug release kinetic. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/21797662/Formulation_development_of_carvedilol_compression_coated_tablet_ DB - PRIME DP - Unbound Medicine ER -