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The thermo-TRP ion channel family: properties and therapeutic implications.
Br J Pharmacol. 2012 Feb; 165(4):787-801.BJ

Abstract

The thermo-transient receptor potentials (TRPs), a recently discovered family of ion channels activated by temperature, are expressed in primary sensory nerve terminals where they provide information about thermal changes in the environment. Six thermo-TRPs have been characterised to date: TRP vanilloid (TRPV) 1 and 2 are activated by painful levels of heat, TRPV3 and 4 respond to non-painful warmth, TRP melastatin 8 is activated by non-painful cool temperatures, while TRP ankyrin (TRPA) 1 is activated by painful cold. The thermal thresholds of many thermo-TRPs are known to be modulated by extracellular mediators, released by tissue damage or inflammation, such as bradykinin, PG and growth factors. There have been intensive efforts recently to develop antagonists of thermo-TRP channels, particularly of the noxious thermal sensors TRPV1 and TRPA1. Blockers of these channels are likely to have therapeutic uses as novel analgesics, but may also cause unacceptable side effects. Controlling the modulation of thermo-TRPs by inflammatory mediators may be a useful alternative strategy in developing novel analgesics.

Authors+Show Affiliations

Department of Pharmacology, University of Cambridge, Cambridge, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21797839

Citation

Vay, Laura, et al. "The thermo-TRP Ion Channel Family: Properties and Therapeutic Implications." British Journal of Pharmacology, vol. 165, no. 4, 2012, pp. 787-801.
Vay L, Gu C, McNaughton PA. The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol. 2012;165(4):787-801.
Vay, L., Gu, C., & McNaughton, P. A. (2012). The thermo-TRP ion channel family: properties and therapeutic implications. British Journal of Pharmacology, 165(4), 787-801. https://doi.org/10.1111/j.1476-5381.2011.01601.x
Vay L, Gu C, McNaughton PA. The thermo-TRP Ion Channel Family: Properties and Therapeutic Implications. Br J Pharmacol. 2012;165(4):787-801. PubMed PMID: 21797839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The thermo-TRP ion channel family: properties and therapeutic implications. AU - Vay,Laura, AU - Gu,Chunjing, AU - McNaughton,Peter A, PY - 2011/7/30/entrez PY - 2011/7/30/pubmed PY - 2012/5/18/medline SP - 787 EP - 801 JF - British journal of pharmacology JO - Br J Pharmacol VL - 165 IS - 4 N2 - The thermo-transient receptor potentials (TRPs), a recently discovered family of ion channels activated by temperature, are expressed in primary sensory nerve terminals where they provide information about thermal changes in the environment. Six thermo-TRPs have been characterised to date: TRP vanilloid (TRPV) 1 and 2 are activated by painful levels of heat, TRPV3 and 4 respond to non-painful warmth, TRP melastatin 8 is activated by non-painful cool temperatures, while TRP ankyrin (TRPA) 1 is activated by painful cold. The thermal thresholds of many thermo-TRPs are known to be modulated by extracellular mediators, released by tissue damage or inflammation, such as bradykinin, PG and growth factors. There have been intensive efforts recently to develop antagonists of thermo-TRP channels, particularly of the noxious thermal sensors TRPV1 and TRPA1. Blockers of these channels are likely to have therapeutic uses as novel analgesics, but may also cause unacceptable side effects. Controlling the modulation of thermo-TRPs by inflammatory mediators may be a useful alternative strategy in developing novel analgesics. SN - 1476-5381 UR - https://www.unboundmedicine.com/medline/citation/21797839/The_thermo_TRP_ion_channel_family:_properties_and_therapeutic_implications_ L2 - https://doi.org/10.1111/j.1476-5381.2011.01601.x DB - PRIME DP - Unbound Medicine ER -