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Cardiac arrhythmias in obstructive sleep apnea (from the Akershus Sleep Apnea Project).
Am J Cardiol. 2011 Oct 15; 108(8):1141-6.AJ

Abstract

Increased prevalence of cardiac arrhythmias has been reported in patients with severe obstructive sleep apnea (OSA), but this may not be generalizable to patients from the general population with a milder form of the condition. The aim of this study was to assess the association between cardiac arrhythmias and OSA of mainly mild and moderate severity. In total, 486 subjects (mean age 49 years, 55% men) recruited from a population-based study in Norway underwent polysomnography for OSA assessment and Holter recordings for arrhythmia assessment. Of these, 271 patients were diagnosed with OSA (apnea-hypopnea index [AHI] ≥5, median AHI 16.8, quartiles 1 to 3 8.9 to 32.6). Mean nadir oxygen saturations were 82% and 89% in patients with and without OSA, respectively. Ventricular premature complexes (≥5/hour) were more prevalent in subjects with OSA compared to subjects without OSA (median AHI 1.4, quartiles 1 to 3 0.5 to 3.0) during the night (12.2% vs 4.7%, p = 0.005) and day (14% vs 5.1%, p = 0.002). In multivariate analysis after adjusting for relevant confounders, AHI was independently associated with an increased prevalence of ventricular premature complexes at night (odds ratio per 1-U increase of log-transformed AHI 1.5, 95% confidence interval 1.1 to 2.0, p = 0.008) and during the day (odds ratio 1.37, 95% confidence interval 1.0 to 1.8, p = 0.035). In conclusion, the prevalence of ventricular premature complexes is increased in middle-aged patients with mainly mild or moderate OSA, suggesting an association between OSA and ventricular arrhythmias even in mild OSA.

Authors+Show Affiliations

Division of Medicine, Akershus University Hospital, Lørenskog, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21798493

Citation

Namtvedt, Silje K., et al. "Cardiac Arrhythmias in Obstructive Sleep Apnea (from the Akershus Sleep Apnea Project)." The American Journal of Cardiology, vol. 108, no. 8, 2011, pp. 1141-6.
Namtvedt SK, Randby A, Einvik G, et al. Cardiac arrhythmias in obstructive sleep apnea (from the Akershus Sleep Apnea Project). Am J Cardiol. 2011;108(8):1141-6.
Namtvedt, S. K., Randby, A., Einvik, G., Hrubos-Strøm, H., Somers, V. K., Røsjø, H., & Omland, T. (2011). Cardiac arrhythmias in obstructive sleep apnea (from the Akershus Sleep Apnea Project). The American Journal of Cardiology, 108(8), 1141-6. https://doi.org/10.1016/j.amjcard.2011.06.016
Namtvedt SK, et al. Cardiac Arrhythmias in Obstructive Sleep Apnea (from the Akershus Sleep Apnea Project). Am J Cardiol. 2011 Oct 15;108(8):1141-6. PubMed PMID: 21798493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac arrhythmias in obstructive sleep apnea (from the Akershus Sleep Apnea Project). AU - Namtvedt,Silje K, AU - Randby,Anna, AU - Einvik,Gunnar, AU - Hrubos-Strøm,Harald, AU - Somers,Virend K, AU - Røsjø,Helge, AU - Omland,Torbjørn, Y1 - 2011/07/27/ PY - 2011/05/07/received PY - 2011/06/09/revised PY - 2011/06/09/accepted PY - 2011/7/30/entrez PY - 2011/7/30/pubmed PY - 2011/12/13/medline SP - 1141 EP - 6 JF - The American journal of cardiology JO - Am J Cardiol VL - 108 IS - 8 N2 - Increased prevalence of cardiac arrhythmias has been reported in patients with severe obstructive sleep apnea (OSA), but this may not be generalizable to patients from the general population with a milder form of the condition. The aim of this study was to assess the association between cardiac arrhythmias and OSA of mainly mild and moderate severity. In total, 486 subjects (mean age 49 years, 55% men) recruited from a population-based study in Norway underwent polysomnography for OSA assessment and Holter recordings for arrhythmia assessment. Of these, 271 patients were diagnosed with OSA (apnea-hypopnea index [AHI] ≥5, median AHI 16.8, quartiles 1 to 3 8.9 to 32.6). Mean nadir oxygen saturations were 82% and 89% in patients with and without OSA, respectively. Ventricular premature complexes (≥5/hour) were more prevalent in subjects with OSA compared to subjects without OSA (median AHI 1.4, quartiles 1 to 3 0.5 to 3.0) during the night (12.2% vs 4.7%, p = 0.005) and day (14% vs 5.1%, p = 0.002). In multivariate analysis after adjusting for relevant confounders, AHI was independently associated with an increased prevalence of ventricular premature complexes at night (odds ratio per 1-U increase of log-transformed AHI 1.5, 95% confidence interval 1.1 to 2.0, p = 0.008) and during the day (odds ratio 1.37, 95% confidence interval 1.0 to 1.8, p = 0.035). In conclusion, the prevalence of ventricular premature complexes is increased in middle-aged patients with mainly mild or moderate OSA, suggesting an association between OSA and ventricular arrhythmias even in mild OSA. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/21798493/Cardiac_arrhythmias_in_obstructive_sleep_apnea__from_the_Akershus_Sleep_Apnea_Project__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(11)02005-4 DB - PRIME DP - Unbound Medicine ER -