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Development and psychometric validation of the Clinical Assessment Interview for Negative Symptoms (CAINS).
Schizophr Res 2011; 132(2-3):140-5SR

Abstract

Progress in the development of new pharmacological and psychosocial treatments for the negative symptoms of schizophrenia is impeded by limitations of available assessment instruments. The multi-site Collaboration to Advance Negative Symptom Assessment in Schizophrenia (CANSAS) was established to develop and validate a new clinical rating scale using a transparent, iterative, and data-driven process. The Clinical Assessment Interview for Negative Symptoms (CAINS) was designed to address limitations of existing measures and assess consensus-based sub-domains, including asociality, avolition, anhedonia, affective blunting, and alogia. The structure and psychometric properties of the CAINS were evaluated in a sample of 281 schizophrenia and schizoaffective outpatients at four sites. Converging structural analyses indicated that the scale was comprised of two moderately correlated factors - one reflecting experiential impairments (diminished motivation and enjoyment of social, vocational, and recreational activities) and one reflecting expressive impairments (diminished non-verbal and verbal communication). Item-level analyses revealed generally good distributional properties, inter-rater agreement, discriminating anchor points, and preliminary convergent and discriminant validity. Results indicate that the CAINS is a promising new measure for quantifying negative symptoms in clinical neuroscience and treatment studies. Results guided item modification or deletion, and the reliability and validity of the revised, shorter version of the CAINS is in the final phase of development within the CANSAS project.

Authors+Show Affiliations

VA Greater Los Angeles Healthcare System, University of California, Los Angeles, California, United States. horan@ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21798716

Citation

Horan, William P., et al. "Development and Psychometric Validation of the Clinical Assessment Interview for Negative Symptoms (CAINS)." Schizophrenia Research, vol. 132, no. 2-3, 2011, pp. 140-5.
Horan WP, Kring AM, Gur RE, et al. Development and psychometric validation of the Clinical Assessment Interview for Negative Symptoms (CAINS). Schizophr Res. 2011;132(2-3):140-5.
Horan, W. P., Kring, A. M., Gur, R. E., Reise, S. P., & Blanchard, J. J. (2011). Development and psychometric validation of the Clinical Assessment Interview for Negative Symptoms (CAINS). Schizophrenia Research, 132(2-3), pp. 140-5. doi:10.1016/j.schres.2011.06.030.
Horan WP, et al. Development and Psychometric Validation of the Clinical Assessment Interview for Negative Symptoms (CAINS). Schizophr Res. 2011;132(2-3):140-5. PubMed PMID: 21798716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and psychometric validation of the Clinical Assessment Interview for Negative Symptoms (CAINS). AU - Horan,William P, AU - Kring,Ann M, AU - Gur,Raquel E, AU - Reise,Steven P, AU - Blanchard,Jack J, Y1 - 2011/07/27/ PY - 2011/05/04/received PY - 2011/06/29/revised PY - 2011/06/30/accepted PY - 2011/7/30/entrez PY - 2011/7/30/pubmed PY - 2012/2/10/medline SP - 140 EP - 5 JF - Schizophrenia research JO - Schizophr. Res. VL - 132 IS - 2-3 N2 - Progress in the development of new pharmacological and psychosocial treatments for the negative symptoms of schizophrenia is impeded by limitations of available assessment instruments. The multi-site Collaboration to Advance Negative Symptom Assessment in Schizophrenia (CANSAS) was established to develop and validate a new clinical rating scale using a transparent, iterative, and data-driven process. The Clinical Assessment Interview for Negative Symptoms (CAINS) was designed to address limitations of existing measures and assess consensus-based sub-domains, including asociality, avolition, anhedonia, affective blunting, and alogia. The structure and psychometric properties of the CAINS were evaluated in a sample of 281 schizophrenia and schizoaffective outpatients at four sites. Converging structural analyses indicated that the scale was comprised of two moderately correlated factors - one reflecting experiential impairments (diminished motivation and enjoyment of social, vocational, and recreational activities) and one reflecting expressive impairments (diminished non-verbal and verbal communication). Item-level analyses revealed generally good distributional properties, inter-rater agreement, discriminating anchor points, and preliminary convergent and discriminant validity. Results indicate that the CAINS is a promising new measure for quantifying negative symptoms in clinical neuroscience and treatment studies. Results guided item modification or deletion, and the reliability and validity of the revised, shorter version of the CAINS is in the final phase of development within the CANSAS project. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/21798716/Development_and_psychometric_validation_of_the_Clinical_Assessment_Interview_for_Negative_Symptoms__CAINS__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(11)00367-7 DB - PRIME DP - Unbound Medicine ER -