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Dietary potassium intake and risk of stroke: a dose-response meta-analysis of prospective studies.
Stroke 2011; 42(10):2746-50S

Abstract

BACKGROUND AND PURPOSE

Potassium intake has been inconsistently associated with risk of stroke. Our aim was to conduct a meta-analysis of prospective studies to assess the relation between potassium intake and stroke risk.

METHODS

Pertinent studies were identified by a search of PubMed from January 1966 through March 2011 and by reviewing the reference lists of retrieved articles. We included prospective studies that reported relative risks with 95% CIs of stroke for ≥3 categories of potassium intake or for potassium intake analyzed as a continuous variable. Study-specific results were pooled using a random-effects model.

RESULTS

Ten independent prospective studies, with a total of 8695 stroke cases and 268 276 participants, were included in the meta-analysis. We observed a statistically significant inverse association between potassium intake and risk of stroke. For every 1000-mg/day increase in potassium intake, the risk of stroke decreased by 11% (pooled relative risk, 0.89; 95% CI, 0.83 to 0.97). In the 5 studies that reported results for stroke subtypes, the pooled relative risks were 0.89 (95% CI, 0.81 to 0.97) for ischemic stroke, 0.95 (95% CI, 0.83 to 1.09) for intracerebral hemorrhage, and 1.08 (95% CI, 0.92 to 1.27) for subarachnoid hemorrhage.

CONCLUSIONS

Dietary potassium intake is inversely associated with risk of stroke, in particular ischemic stroke.

Authors+Show Affiliations

Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-17177 Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21799170

Citation

Larsson, Susanna C., et al. "Dietary Potassium Intake and Risk of Stroke: a Dose-response Meta-analysis of Prospective Studies." Stroke, vol. 42, no. 10, 2011, pp. 2746-50.
Larsson SC, Orsini N, Wolk A. Dietary potassium intake and risk of stroke: a dose-response meta-analysis of prospective studies. Stroke. 2011;42(10):2746-50.
Larsson, S. C., Orsini, N., & Wolk, A. (2011). Dietary potassium intake and risk of stroke: a dose-response meta-analysis of prospective studies. Stroke, 42(10), pp. 2746-50. doi:10.1161/STROKEAHA.111.622142.
Larsson SC, Orsini N, Wolk A. Dietary Potassium Intake and Risk of Stroke: a Dose-response Meta-analysis of Prospective Studies. Stroke. 2011;42(10):2746-50. PubMed PMID: 21799170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary potassium intake and risk of stroke: a dose-response meta-analysis of prospective studies. AU - Larsson,Susanna C, AU - Orsini,Nicola, AU - Wolk,Alicja, Y1 - 2011/07/28/ PY - 2011/7/30/entrez PY - 2011/7/30/pubmed PY - 2012/8/14/medline SP - 2746 EP - 50 JF - Stroke JO - Stroke VL - 42 IS - 10 N2 - BACKGROUND AND PURPOSE: Potassium intake has been inconsistently associated with risk of stroke. Our aim was to conduct a meta-analysis of prospective studies to assess the relation between potassium intake and stroke risk. METHODS: Pertinent studies were identified by a search of PubMed from January 1966 through March 2011 and by reviewing the reference lists of retrieved articles. We included prospective studies that reported relative risks with 95% CIs of stroke for ≥3 categories of potassium intake or for potassium intake analyzed as a continuous variable. Study-specific results were pooled using a random-effects model. RESULTS: Ten independent prospective studies, with a total of 8695 stroke cases and 268 276 participants, were included in the meta-analysis. We observed a statistically significant inverse association between potassium intake and risk of stroke. For every 1000-mg/day increase in potassium intake, the risk of stroke decreased by 11% (pooled relative risk, 0.89; 95% CI, 0.83 to 0.97). In the 5 studies that reported results for stroke subtypes, the pooled relative risks were 0.89 (95% CI, 0.81 to 0.97) for ischemic stroke, 0.95 (95% CI, 0.83 to 1.09) for intracerebral hemorrhage, and 1.08 (95% CI, 0.92 to 1.27) for subarachnoid hemorrhage. CONCLUSIONS: Dietary potassium intake is inversely associated with risk of stroke, in particular ischemic stroke. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/21799170/Dietary_potassium_intake_and_risk_of_stroke:_a_dose_response_meta_analysis_of_prospective_studies_ L2 - http://www.ahajournals.org/doi/full/10.1161/STROKEAHA.111.622142?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -