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Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus.
Am J Vet Res. 2011 Aug; 72(8):1052-8.AJ

Abstract

OBJECTIVE

To evaluate and compare circulating concentrations of islet amyloid polypeptide (IAPP), insulin, and glucose in nondiabetic cats classified by body condition score (BCS) and in cats with naturally occurring diabetes mellitus.

ANIMALS

109 (82 nondiabetic, 21 nonketoacidotic diabetic, and 6 ketoacidotic diabetic) cats.

PROCEDURES

Cats were examined and BCSs were assessed on a scale of 1 to 9. After food was withheld for 12 hours, blood was collected and plasma concentrations of IAPP and serum concentrations of insulin and glucose were measured. Differences in these values were evaluated among nondiabetic cats grouped according to BCS and in diabetic cats grouped as ketoacidotic or nonketoacidotic on the basis of clinicopathologic findings. Correlations were determined among variables.

RESULTS

In nondiabetic cats, BCS was significantly and positively correlated with circulating IAPP and insulin concentrations. Mean plasma IAPP concentrations were significantly different between cats with BCSs of 5 and 7, and mean serum insulin concentrations were significantly different between cats with BCSs of 5 and 8. Serum glucose concentrations were not significantly different among nondiabetic cats. Mean IAPP concentrations were similar between nonketoacidotic diabetic cats and nondiabetic cats with BCSs of 8 or 9. Mean IAPP concentrations were significantly reduced in ketoacidotic diabetic cats, compared with those of nondiabetic cats with BCSs of 6 through 8 and of nonketoacidotic diabetic cats.

CONCLUSIONS AND CLINICAL RELEVANCE

Results indicated that increased BCS (a measure of obesity) is associated with increased circulating concentrations of IAPP and insulin in nondiabetic cats.

Authors+Show Affiliations

Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, Saint Paul, MN 55108, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21801062

Citation

Henson, Michael S., et al. "Evaluation of Plasma Islet Amyloid Polypeptide and Serum Glucose and Insulin Concentrations in Nondiabetic Cats Classified By Body Condition Score and in Cats With Naturally Occurring Diabetes Mellitus." American Journal of Veterinary Research, vol. 72, no. 8, 2011, pp. 1052-8.
Henson MS, Hegstad-Davies RL, Wang Q, et al. Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus. Am J Vet Res. 2011;72(8):1052-8.
Henson, M. S., Hegstad-Davies, R. L., Wang, Q., Hardy, R. M., Armstrong, P. J., Jordan, K., Johnson, K. H., & O'Brien, T. D. (2011). Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus. American Journal of Veterinary Research, 72(8), 1052-8. https://doi.org/10.2460/ajvr.72.8.1052
Henson MS, et al. Evaluation of Plasma Islet Amyloid Polypeptide and Serum Glucose and Insulin Concentrations in Nondiabetic Cats Classified By Body Condition Score and in Cats With Naturally Occurring Diabetes Mellitus. Am J Vet Res. 2011;72(8):1052-8. PubMed PMID: 21801062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus. AU - Henson,Michael S, AU - Hegstad-Davies,Rebecca L, AU - Wang,Qi, AU - Hardy,Robert M, AU - Armstrong,P Jane, AU - Jordan,Kathryn, AU - Johnson,Kenneth H, AU - O'Brien,Timothy D, PY - 2011/8/2/entrez PY - 2011/8/2/pubmed PY - 2011/12/13/medline SP - 1052 EP - 8 JF - American journal of veterinary research JO - Am J Vet Res VL - 72 IS - 8 N2 - OBJECTIVE: To evaluate and compare circulating concentrations of islet amyloid polypeptide (IAPP), insulin, and glucose in nondiabetic cats classified by body condition score (BCS) and in cats with naturally occurring diabetes mellitus. ANIMALS: 109 (82 nondiabetic, 21 nonketoacidotic diabetic, and 6 ketoacidotic diabetic) cats. PROCEDURES: Cats were examined and BCSs were assessed on a scale of 1 to 9. After food was withheld for 12 hours, blood was collected and plasma concentrations of IAPP and serum concentrations of insulin and glucose were measured. Differences in these values were evaluated among nondiabetic cats grouped according to BCS and in diabetic cats grouped as ketoacidotic or nonketoacidotic on the basis of clinicopathologic findings. Correlations were determined among variables. RESULTS: In nondiabetic cats, BCS was significantly and positively correlated with circulating IAPP and insulin concentrations. Mean plasma IAPP concentrations were significantly different between cats with BCSs of 5 and 7, and mean serum insulin concentrations were significantly different between cats with BCSs of 5 and 8. Serum glucose concentrations were not significantly different among nondiabetic cats. Mean IAPP concentrations were similar between nonketoacidotic diabetic cats and nondiabetic cats with BCSs of 8 or 9. Mean IAPP concentrations were significantly reduced in ketoacidotic diabetic cats, compared with those of nondiabetic cats with BCSs of 6 through 8 and of nonketoacidotic diabetic cats. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that increased BCS (a measure of obesity) is associated with increased circulating concentrations of IAPP and insulin in nondiabetic cats. SN - 1943-5681 UR - https://www.unboundmedicine.com/medline/citation/21801062/Evaluation_of_plasma_islet_amyloid_polypeptide_and_serum_glucose_and_insulin_concentrations_in_nondiabetic_cats_classified_by_body_condition_score_and_in_cats_with_naturally_occurring_diabetes_mellitus_ L2 - https://avmajournals.avma.org/doi/10.2460/ajvr.72.8.1052?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -