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Delayed oseltamivir treatment is associated with longer viral shedding of pandemic (H1N1) 2009 virus.
Epidemiol Infect 2012; 140(5):814-7EI

Abstract

During the early phase of the influenza pandemic in 2009, all cases of laboratory-confirmed pandemic (H1N1) 2009 (pH1N1) infection required compulsory isolation in hospital. These cases were offered oseltamivir treatment and only allowed to be discharged from the hospital when three consecutive respiratory specimens were negative for the virus by reverse transcription-polymerase chain reaction (RT-PCR). We reviewed the case records of these patients to assess the viral shedding kinetics of the pH1N1 virus. We defined viral shedding duration as the interval from illness onset date to the date of collection of the last positive specimen from the patients. Fifty-six patients were included in the study, of whom 96% received oseltamivir. The median viral shedding duration of pH1N1 virus by viral culture and RT-PCR were 3 days and 4 days, respectively. Patients who started oseltamivir treatment >48 h after onset had a significantly longer median viral shedding duration by viral culture than those who started treatment within 48 h of onset (4 days vs. 2 days, P=0·014).

Authors+Show Affiliations

Field Epidemiology Training Programme, Centre for Health Protection, Department of Health, Hong Kong, People's Republic of China. mo_fetp1@dh.gov.hkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21801465

Citation

Leung, Y H., et al. "Delayed Oseltamivir Treatment Is Associated With Longer Viral Shedding of Pandemic (H1N1) 2009 Virus." Epidemiology and Infection, vol. 140, no. 5, 2012, pp. 814-7.
Leung YH, Lim WL, Wong MH, et al. Delayed oseltamivir treatment is associated with longer viral shedding of pandemic (H1N1) 2009 virus. Epidemiol Infect. 2012;140(5):814-7.
Leung, Y. H., Lim, W. L., Wong, M. H., & Chuang, S. K. (2012). Delayed oseltamivir treatment is associated with longer viral shedding of pandemic (H1N1) 2009 virus. Epidemiology and Infection, 140(5), pp. 814-7. doi:10.1017/S0950268811001415.
Leung YH, et al. Delayed Oseltamivir Treatment Is Associated With Longer Viral Shedding of Pandemic (H1N1) 2009 Virus. Epidemiol Infect. 2012;140(5):814-7. PubMed PMID: 21801465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delayed oseltamivir treatment is associated with longer viral shedding of pandemic (H1N1) 2009 virus. AU - Leung,Y H, AU - Lim,W L, AU - Wong,M H, AU - Chuang,S K, Y1 - 2011/07/29/ PY - 2011/8/2/entrez PY - 2011/8/2/pubmed PY - 2012/5/17/medline SP - 814 EP - 7 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 140 IS - 5 N2 - During the early phase of the influenza pandemic in 2009, all cases of laboratory-confirmed pandemic (H1N1) 2009 (pH1N1) infection required compulsory isolation in hospital. These cases were offered oseltamivir treatment and only allowed to be discharged from the hospital when three consecutive respiratory specimens were negative for the virus by reverse transcription-polymerase chain reaction (RT-PCR). We reviewed the case records of these patients to assess the viral shedding kinetics of the pH1N1 virus. We defined viral shedding duration as the interval from illness onset date to the date of collection of the last positive specimen from the patients. Fifty-six patients were included in the study, of whom 96% received oseltamivir. The median viral shedding duration of pH1N1 virus by viral culture and RT-PCR were 3 days and 4 days, respectively. Patients who started oseltamivir treatment >48 h after onset had a significantly longer median viral shedding duration by viral culture than those who started treatment within 48 h of onset (4 days vs. 2 days, P=0·014). SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/21801465/Delayed_oseltamivir_treatment_is_associated_with_longer_viral_shedding_of_pandemic__H1N1__2009_virus_ L2 - https://www.cambridge.org/core/product/identifier/S0950268811001415/type/journal_article DB - PRIME DP - Unbound Medicine ER -