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Congenital central hypoventilation syndrome and desogestrel: a call for caution: addendum to "C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski, Chemosensitivity recovery in Ondine's curse syndrome under treatment with desogestrel" [Respir. Physiol. Neurobiol. 171 (2010) 171-174].
Respir Physiol Neurobiol. 2011 Sep 15; 178(2):357-8.RP

Abstract

Patients suffering from congenital central hypoventilation syndrome (CCHS) depend on mechanical ventilation during sleep, from birth and throughout life. They lack CO2-chemosensitivity. Hope has recently been raised by serendipitous observations of chemosensitivity recovery under treatment by desogestrel, a very potent progestin (Straus et al., 2010). Caution is however needed, because this effect could depend on dose, idiosyncrasies, or be transient. Desogestrel should not be prescribed to CCHS patients with a respiratory purpose until the results of a pending clinical trial (clinicaltrials.gov. NCT01243697) are available.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Straus C
Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Service Central d'Explorations Fonctionnelles Respiratoires et Service de Pneumologie et Réanimation Médicale, F-75013 Paris, France. christian.straus@psl.aphp.fr
Similowski T
No affiliation info available

MeSH

Carbon DioxideChemoreceptor CellsContraindicationsDesogestrelHumansHypoventilationRecovery of FunctionSleep Apnea, CentralTreatment Outcome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21801857

Clinical Trial Links

Clinical trial which this article describes

Citation

Straus, Christian, and Thomas Similowski. "Congenital Central Hypoventilation Syndrome and Desogestrel: a Call for Caution: Addendum to "C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski, Chemosensitivity Recovery in Ondine's Curse Syndrome Under Treatment With Desogestrel" [Respir. Physiol. Neurobiol. 171 (2010) 171-174]." Respiratory Physiology & Neurobiology, vol. 178, no. 2, 2011, pp. 357-8.
Straus C, Similowski T. Congenital central hypoventilation syndrome and desogestrel: a call for caution: addendum to "C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski, Chemosensitivity recovery in Ondine's curse syndrome under treatment with desogestrel" [Respir. Physiol. Neurobiol. 171 (2010) 171-174]. Respir Physiol Neurobiol. 2011;178(2):357-8.
Straus, C., & Similowski, T. (2011). Congenital central hypoventilation syndrome and desogestrel: a call for caution: addendum to "C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski, Chemosensitivity recovery in Ondine's curse syndrome under treatment with desogestrel" [Respir. Physiol. Neurobiol. 171 (2010) 171-174]. Respiratory Physiology & Neurobiology, 178(2), 357-8. https://doi.org/10.1016/j.resp.2011.07.007
Straus C, Similowski T. Congenital Central Hypoventilation Syndrome and Desogestrel: a Call for Caution: Addendum to "C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski, Chemosensitivity Recovery in Ondine's Curse Syndrome Under Treatment With Desogestrel" [Respir. Physiol. Neurobiol. 171 (2010) 171-174]. Respir Physiol Neurobiol. 2011 Sep 15;178(2):357-8. PubMed PMID: 21801857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Congenital central hypoventilation syndrome and desogestrel: a call for caution: addendum to "C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski, Chemosensitivity recovery in Ondine's curse syndrome under treatment with desogestrel" [Respir. Physiol. Neurobiol. 171 (2010) 171-174]. AU - Straus,Christian, AU - Similowski,Thomas, Y1 - 2011/07/23/ PY - 2011/07/04/revised PY - 2011/07/04/accepted PY - 2011/8/2/entrez PY - 2011/8/2/pubmed PY - 2012/6/12/medline SP - 357 EP - 8 JF - Respiratory physiology & neurobiology JO - Respir Physiol Neurobiol VL - 178 IS - 2 N2 - Patients suffering from congenital central hypoventilation syndrome (CCHS) depend on mechanical ventilation during sleep, from birth and throughout life. They lack CO2-chemosensitivity. Hope has recently been raised by serendipitous observations of chemosensitivity recovery under treatment by desogestrel, a very potent progestin (Straus et al., 2010). Caution is however needed, because this effect could depend on dose, idiosyncrasies, or be transient. Desogestrel should not be prescribed to CCHS patients with a respiratory purpose until the results of a pending clinical trial (clinicaltrials.gov. NCT01243697) are available. SN - 1878-1519 UR - https://www.unboundmedicine.com/medline/citation/21801857/Congenital_central_hypoventilation_syndrome_and_desogestrel:_a_call_for_caution:_addendum_to_"C__Straus_H__Trang_M_H__Becquemin_P__Touraine_T__Similowski_Chemosensitivity_recovery_in_Ondine's_curse_syndrome_under_treatment_with_desogestrel"_[Respir__Physiol__Neurobiol__171__2010__171_174]_ DB - PRIME DP - Unbound Medicine ER -