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Postthrombotic syndrome and quality of life in patients with iliofemoral venous thrombosis treated with catheter-directed thrombolysis.
J Vasc Surg 2011; 54(6 Suppl):18S-25SJV

Abstract

BACKGROUND

Postthrombotic syndrome (PTS) is a common complication after iliofemoral venous thrombosis, often resulting in poor quality of life (QOL) among the affected patients. This study assessed development of PTS and its effect on QOL among patients treated for iliofemoral venous thrombosis by catheter-directed thrombolysis.

METHODS

Patients admitted with an iliofemoral venous thrombosis and treated with catheter-directed thrombolysis at Gentofte University Hospital from 1999 to 2008 were invited to participate. Duplex ultrasound imaging was used to assess venous patency and valve function. Each patient completed the generic Short-Form 36-item (SF-36) health survey assessment, producing physical component (PCS) and mental component summary (MCS) scores, and the disease-specific Venous Insufficiency Epidemiological and Economic Study (VEINES)-Quality of Life (QOL)/Symptoms (Sym), questionnaires to assess QOL. PTS was assessed using the Villalta scale.

RESULTS

The study included 109 patients. Median follow-up was 71 months. PTS developed in 18 patients (16.5%) and of those, initial thrombolysis was successful in 13. Patients with PTS had significantly worse mean ± standard deviation scores than patients without PTS on VEINES-QOL (34.2 ± 9.6 vs 53.1 ± 6.6; P < .0001), VEINES-Sym (34.0 ± 8.8 vs 53.2 ± 6.6; P < .0001), SF-36 MCS (44.2 ± 15.5 vs 52.3 ± 11.0; P = .005), and SF-36 PCS (42.3 ± 9.1 vs 53.5 ± 7.8; P < .0001) subscales. Patients with reflux or chronic occlusions, or both, had significantly lower mean ± SD scores than patients with patent veins without reflux on VEINES-QOL (43.5 ± 14.3 vs 51.0 ± 8.8; P = .044) and SF-36 PCS (47.2 ± 10.9 vs 52.4 ± 8.5; P = .049) scales.

CONCLUSION

PTS was associated with worse QOL, although only a few patients developed PTS after catheter-directed thrombolysis of iliofemoral venous thrombosis. Patients with patent veins and sufficient valves have higher QOL scores than patients with reflux and occluded veins.

Authors+Show Affiliations

Department of Vascular Surgery, Rigshospitalet and Gentofte, University of Copenhagen, Copenhagen, Denmark. rbroholm@dadlnet.dk

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21802243

Citation

Broholm, Rikke, et al. "Postthrombotic Syndrome and Quality of Life in Patients With Iliofemoral Venous Thrombosis Treated With Catheter-directed Thrombolysis." Journal of Vascular Surgery, vol. 54, no. 6 Suppl, 2011, 18S-25S.
Broholm R, Sillesen H, Damsgaard MT, et al. Postthrombotic syndrome and quality of life in patients with iliofemoral venous thrombosis treated with catheter-directed thrombolysis. J Vasc Surg. 2011;54(6 Suppl):18S-25S.
Broholm, R., Sillesen, H., Damsgaard, M. T., Jørgensen, M., Just, S., Jensen, L. P., & Bækgaard, N. (2011). Postthrombotic syndrome and quality of life in patients with iliofemoral venous thrombosis treated with catheter-directed thrombolysis. Journal of Vascular Surgery, 54(6 Suppl), 18S-25S. doi:10.1016/j.jvs.2011.06.021.
Broholm R, et al. Postthrombotic Syndrome and Quality of Life in Patients With Iliofemoral Venous Thrombosis Treated With Catheter-directed Thrombolysis. J Vasc Surg. 2011;54(6 Suppl):18S-25S. PubMed PMID: 21802243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postthrombotic syndrome and quality of life in patients with iliofemoral venous thrombosis treated with catheter-directed thrombolysis. AU - Broholm,Rikke, AU - Sillesen,Henrik, AU - Damsgaard,Mogens Trab, AU - Jørgensen,Maja, AU - Just,Sven, AU - Jensen,Leif Panduro, AU - Bækgaard,Niels, Y1 - 2011/07/29/ PY - 2010/10/25/received PY - 2011/06/01/revised PY - 2011/06/01/accepted PY - 2011/8/2/entrez PY - 2011/8/2/pubmed PY - 2012/1/24/medline SP - 18S EP - 25S JF - Journal of vascular surgery JO - J. Vasc. Surg. VL - 54 IS - 6 Suppl N2 - BACKGROUND: Postthrombotic syndrome (PTS) is a common complication after iliofemoral venous thrombosis, often resulting in poor quality of life (QOL) among the affected patients. This study assessed development of PTS and its effect on QOL among patients treated for iliofemoral venous thrombosis by catheter-directed thrombolysis. METHODS: Patients admitted with an iliofemoral venous thrombosis and treated with catheter-directed thrombolysis at Gentofte University Hospital from 1999 to 2008 were invited to participate. Duplex ultrasound imaging was used to assess venous patency and valve function. Each patient completed the generic Short-Form 36-item (SF-36) health survey assessment, producing physical component (PCS) and mental component summary (MCS) scores, and the disease-specific Venous Insufficiency Epidemiological and Economic Study (VEINES)-Quality of Life (QOL)/Symptoms (Sym), questionnaires to assess QOL. PTS was assessed using the Villalta scale. RESULTS: The study included 109 patients. Median follow-up was 71 months. PTS developed in 18 patients (16.5%) and of those, initial thrombolysis was successful in 13. Patients with PTS had significantly worse mean ± standard deviation scores than patients without PTS on VEINES-QOL (34.2 ± 9.6 vs 53.1 ± 6.6; P < .0001), VEINES-Sym (34.0 ± 8.8 vs 53.2 ± 6.6; P < .0001), SF-36 MCS (44.2 ± 15.5 vs 52.3 ± 11.0; P = .005), and SF-36 PCS (42.3 ± 9.1 vs 53.5 ± 7.8; P < .0001) subscales. Patients with reflux or chronic occlusions, or both, had significantly lower mean ± SD scores than patients with patent veins without reflux on VEINES-QOL (43.5 ± 14.3 vs 51.0 ± 8.8; P = .044) and SF-36 PCS (47.2 ± 10.9 vs 52.4 ± 8.5; P = .049) scales. CONCLUSION: PTS was associated with worse QOL, although only a few patients developed PTS after catheter-directed thrombolysis of iliofemoral venous thrombosis. Patients with patent veins and sufficient valves have higher QOL scores than patients with reflux and occluded veins. SN - 1097-6809 UR - https://www.unboundmedicine.com/medline/citation/21802243/Postthrombotic_syndrome_and_quality_of_life_in_patients_with_iliofemoral_venous_thrombosis_treated_with_catheter_directed_thrombolysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741-5214(11)01383-8 DB - PRIME DP - Unbound Medicine ER -