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Global analysis of breast feeding and risk of symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children: ISAAC Phase Three.
Allergol Immunopathol (Madr) 2011 Nov-Dec; 39(6):318-25AI

Abstract

BACKGROUND

In Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC), we investigated the relationship between breast feeding in infancy and symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children.

METHODS

Parents or guardians of 6-7 year old children completed written questionnaires on current symptoms of asthma, rhinoconjunctivitis and eczema, and on a range of possible asthma risk factors including a history of breast feeding ever. Prevalence odds ratios were estimated using logistic regression, adjusted for gender, region of the world, language, per capita gross national income, and other risk factors.

RESULTS

In all 206,453 children from 72 centres in 31 countries participated in the study. Reported breast feeding ever was not associated with current wheeze, with an odds ratio (adjusted for gender, region of the world, language, per capita gross national income, and factors encountered in infancy) of 0.99 (95% CI 0.92-1.05), current rhinoconjunctivitis (OR 1.00, 95% CI 0.93-1.08), current eczema (OR 1.05, 95% CI 0.97-1.12), or symptoms of severe asthma (OR 0.95, 95% CI 0.87-1.05). Breast feeding was however associated with a reduced risk of severe rhinoconjunctivitis (OR 0.74, 95% CI 0.59-0.94) and severe eczema (OR 0.79, 95% CI 0.66-0.95).

CONCLUSIONS

There was no consistent association between breast feeding use in the first year of life and either a history or current symptoms of wheezing, rhinoconjunctivitis or eczema in 6-7 year old children, but possibly an effect on severe symptoms of the latter two conditions.

Authors+Show Affiliations

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. bengt.bjorksten@ki.sesNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase III
Journal Article
Multicenter Study

Language

eng

PubMed ID

21802826

Citation

Björkstén, B, et al. "Global Analysis of Breast Feeding and Risk of Symptoms of Asthma, Rhinoconjunctivitis and Eczema in 6-7 Year Old Children: ISAAC Phase Three." Allergologia Et Immunopathologia, vol. 39, no. 6, 2011, pp. 318-25.
Björkstén B, Aït-Khaled N, Innes Asher M, et al. Global analysis of breast feeding and risk of symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children: ISAAC Phase Three. Allergol Immunopathol (Madr). 2011;39(6):318-25.
Björkstén, B., Aït-Khaled, N., Innes Asher, M., Clayton, T. O., & Robertson, C. (2011). Global analysis of breast feeding and risk of symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children: ISAAC Phase Three. Allergologia Et Immunopathologia, 39(6), pp. 318-25. doi:10.1016/j.aller.2011.02.005.
Björkstén B, et al. Global Analysis of Breast Feeding and Risk of Symptoms of Asthma, Rhinoconjunctivitis and Eczema in 6-7 Year Old Children: ISAAC Phase Three. Allergol Immunopathol (Madr). 2011;39(6):318-25. PubMed PMID: 21802826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Global analysis of breast feeding and risk of symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children: ISAAC Phase Three. AU - Björkstén,B, AU - Aït-Khaled,N, AU - Innes Asher,M, AU - Clayton,T O, AU - Robertson,C, AU - ,, Y1 - 2011/07/30/ PY - 2011/01/26/received PY - 2011/02/14/accepted PY - 2011/8/2/entrez PY - 2011/8/2/pubmed PY - 2012/3/1/medline SP - 318 EP - 25 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 39 IS - 6 N2 - BACKGROUND: In Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC), we investigated the relationship between breast feeding in infancy and symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children. METHODS: Parents or guardians of 6-7 year old children completed written questionnaires on current symptoms of asthma, rhinoconjunctivitis and eczema, and on a range of possible asthma risk factors including a history of breast feeding ever. Prevalence odds ratios were estimated using logistic regression, adjusted for gender, region of the world, language, per capita gross national income, and other risk factors. RESULTS: In all 206,453 children from 72 centres in 31 countries participated in the study. Reported breast feeding ever was not associated with current wheeze, with an odds ratio (adjusted for gender, region of the world, language, per capita gross national income, and factors encountered in infancy) of 0.99 (95% CI 0.92-1.05), current rhinoconjunctivitis (OR 1.00, 95% CI 0.93-1.08), current eczema (OR 1.05, 95% CI 0.97-1.12), or symptoms of severe asthma (OR 0.95, 95% CI 0.87-1.05). Breast feeding was however associated with a reduced risk of severe rhinoconjunctivitis (OR 0.74, 95% CI 0.59-0.94) and severe eczema (OR 0.79, 95% CI 0.66-0.95). CONCLUSIONS: There was no consistent association between breast feeding use in the first year of life and either a history or current symptoms of wheezing, rhinoconjunctivitis or eczema in 6-7 year old children, but possibly an effect on severe symptoms of the latter two conditions. SN - 1578-1267 UR - https://www.unboundmedicine.com/medline/citation/21802826/Global_analysis_of_breast_feeding_and_risk_of_symptoms_of_asthma_rhinoconjunctivitis_and_eczema_in_6_7_year_old_children:_ISAAC_Phase_Three_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0301-0546(11)00122-4 DB - PRIME DP - Unbound Medicine ER -