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Different IgG-subclass distributions after whole-cell and acellular pertussis infant primary vaccinations in healthy and pertussis infected children.
Vaccine. 2011 Sep 16; 29(40):6874-80.V

Abstract

The distribution of IgG-subclasses provides insight in the immunological mechanisms of protection against whooping cough. We investigated the effect of Dutch whole-cell pertussis and acellular pertussis vaccines administered in infancy on the IgG-subclass distributions in healthy children aged 12 months, 4 years and 9 years as well as in children who have been infected with Bordetella pertussis. A fluorescent bead-based multiplex immunoassay was used for the measurement of IgG1, IgG2, IgG3 and IgG4 responses against pertussis toxin, filamentous heamagglutinin and pertactin. Although IgG1 was the predominant subclass for all pertussis antigens in both healthy and infected children, elevated IgG4 levels were only present in children who had received repeated number of acellular pertussis vaccinations. IgG2 and IgG3 antibodies did not contribute to the IgG response. No differences in IgG-subclasses between healthy vaccinated or infected children were found. The pertussis vaccine used for priming seems to determine the IgG-subclass composition elicited after a secondary antibody response either induced by pertussis vaccination or infection. The pronounced anti-pertussis IgG4 response might reflect the Th2-skewing of the immune response after aP vaccination.

Authors+Show Affiliations

Centre for Infectious Disease and Control (Cib), National Institute for Public Health and the Environment, Bilthoven, The Netherlands. Lotte.Hendrikx@rivm.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21803088

Citation

Hendrikx, Lotte H., et al. "Different IgG-subclass Distributions After Whole-cell and Acellular Pertussis Infant Primary Vaccinations in Healthy and Pertussis Infected Children." Vaccine, vol. 29, no. 40, 2011, pp. 6874-80.
Hendrikx LH, Schure RM, Oztürk K, et al. Different IgG-subclass distributions after whole-cell and acellular pertussis infant primary vaccinations in healthy and pertussis infected children. Vaccine. 2011;29(40):6874-80.
Hendrikx, L. H., Schure, R. M., Oztürk, K., de Rond, L. G., de Greeff, S. C., Sanders, E. A., Berbers, G. A., & Buisman, A. M. (2011). Different IgG-subclass distributions after whole-cell and acellular pertussis infant primary vaccinations in healthy and pertussis infected children. Vaccine, 29(40), 6874-80. https://doi.org/10.1016/j.vaccine.2011.07.055
Hendrikx LH, et al. Different IgG-subclass Distributions After Whole-cell and Acellular Pertussis Infant Primary Vaccinations in Healthy and Pertussis Infected Children. Vaccine. 2011 Sep 16;29(40):6874-80. PubMed PMID: 21803088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different IgG-subclass distributions after whole-cell and acellular pertussis infant primary vaccinations in healthy and pertussis infected children. AU - Hendrikx,Lotte H, AU - Schure,Rose-Minke, AU - Oztürk,Kemal, AU - de Rond,Lia G H, AU - de Greeff,S C, AU - Sanders,Elisabeth A M, AU - Berbers,Guy A M, AU - Buisman,Anne-Marie, Y1 - 2011/07/29/ PY - 2011/06/15/received PY - 2011/07/14/revised PY - 2011/07/16/accepted PY - 2011/8/2/entrez PY - 2011/8/2/pubmed PY - 2012/3/8/medline SP - 6874 EP - 80 JF - Vaccine JO - Vaccine VL - 29 IS - 40 N2 - The distribution of IgG-subclasses provides insight in the immunological mechanisms of protection against whooping cough. We investigated the effect of Dutch whole-cell pertussis and acellular pertussis vaccines administered in infancy on the IgG-subclass distributions in healthy children aged 12 months, 4 years and 9 years as well as in children who have been infected with Bordetella pertussis. A fluorescent bead-based multiplex immunoassay was used for the measurement of IgG1, IgG2, IgG3 and IgG4 responses against pertussis toxin, filamentous heamagglutinin and pertactin. Although IgG1 was the predominant subclass for all pertussis antigens in both healthy and infected children, elevated IgG4 levels were only present in children who had received repeated number of acellular pertussis vaccinations. IgG2 and IgG3 antibodies did not contribute to the IgG response. No differences in IgG-subclasses between healthy vaccinated or infected children were found. The pertussis vaccine used for priming seems to determine the IgG-subclass composition elicited after a secondary antibody response either induced by pertussis vaccination or infection. The pronounced anti-pertussis IgG4 response might reflect the Th2-skewing of the immune response after aP vaccination. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21803088/Different_IgG_subclass_distributions_after_whole_cell_and_acellular_pertussis_infant_primary_vaccinations_in_healthy_and_pertussis_infected_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)01100-5 DB - PRIME DP - Unbound Medicine ER -