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Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men.
Metabolism. 2012 Jan; 61(1):47-55.M

Abstract

This cohort study investigated the association between dietary glycemic index (GI), glycemic load (GL), and the incidence of type 2 diabetes mellitus in middle-aged Japanese men, and the effect of insulin resistance and pancreatic B-cell function on the association. Participants were 1995 male employees of a metal products factory in Japan. Dietary GI and GL were assessed using a self-administered diet history questionnaire. The incidence of diabetes was detected in annual medical examinations over a 6-year period. The association between GI, GL, and the incidence of diabetes was evaluated using Cox proportional hazards models. During the study, 133 participants developed diabetes. Age- and body mass index-adjusted hazard ratios across the GI quintiles were 1.00 (reference), 1.62, 1.50, 1.68, and 1.80; and those of GL were 1.00 (reference), 1.07, 1.48, 0.95, and 0.98. The hazard ratio for the highest GI quintile was significantly greater than that for the lowest quintile. The influence of GI was more pronounced in the lowest insulin resistance subgroups. GI and pancreatic B-cell function were independently associated with the incidence of type 2 diabetes mellitus; participants with low B-cell function and the highest tertile of GI had the highest risk of diabetes. Dietary GI is associated with the incidence of diabetes in middle-aged Japanese men. GI and B-cell function were independently associated with incidence of diabetes.

Authors+Show Affiliations

Department of Epidemiology and Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, Japan. m-sakura@kanazawa-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21803381

Citation

Sakurai, Masaru, et al. "Dietary Glycemic Index and Risk of Type 2 Diabetes Mellitus in Middle-aged Japanese Men." Metabolism: Clinical and Experimental, vol. 61, no. 1, 2012, pp. 47-55.
Sakurai M, Nakamura K, Miura K, et al. Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men. Metab Clin Exp. 2012;61(1):47-55.
Sakurai, M., Nakamura, K., Miura, K., Takamura, T., Yoshita, K., Morikawa, Y., Ishizaki, M., Kido, T., Naruse, Y., Suwazono, Y., Kaneko, S., Sasaki, S., & Nakagawa, H. (2012). Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men. Metabolism: Clinical and Experimental, 61(1), 47-55. https://doi.org/10.1016/j.metabol.2011.05.015
Sakurai M, et al. Dietary Glycemic Index and Risk of Type 2 Diabetes Mellitus in Middle-aged Japanese Men. Metab Clin Exp. 2012;61(1):47-55. PubMed PMID: 21803381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men. AU - Sakurai,Masaru, AU - Nakamura,Koshi, AU - Miura,Katsuyuki, AU - Takamura,Toshinari, AU - Yoshita,Katsushi, AU - Morikawa,Yuko, AU - Ishizaki,Masao, AU - Kido,Teruhiko, AU - Naruse,Yuchi, AU - Suwazono,Yasushi, AU - Kaneko,Shuichi, AU - Sasaki,Satoshi, AU - Nakagawa,Hideaki, Y1 - 2011/07/30/ PY - 2010/12/16/received PY - 2011/05/13/revised PY - 2011/05/16/accepted PY - 2011/8/2/entrez PY - 2011/8/2/pubmed PY - 2012/4/6/medline SP - 47 EP - 55 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 61 IS - 1 N2 - This cohort study investigated the association between dietary glycemic index (GI), glycemic load (GL), and the incidence of type 2 diabetes mellitus in middle-aged Japanese men, and the effect of insulin resistance and pancreatic B-cell function on the association. Participants were 1995 male employees of a metal products factory in Japan. Dietary GI and GL were assessed using a self-administered diet history questionnaire. The incidence of diabetes was detected in annual medical examinations over a 6-year period. The association between GI, GL, and the incidence of diabetes was evaluated using Cox proportional hazards models. During the study, 133 participants developed diabetes. Age- and body mass index-adjusted hazard ratios across the GI quintiles were 1.00 (reference), 1.62, 1.50, 1.68, and 1.80; and those of GL were 1.00 (reference), 1.07, 1.48, 0.95, and 0.98. The hazard ratio for the highest GI quintile was significantly greater than that for the lowest quintile. The influence of GI was more pronounced in the lowest insulin resistance subgroups. GI and pancreatic B-cell function were independently associated with the incidence of type 2 diabetes mellitus; participants with low B-cell function and the highest tertile of GI had the highest risk of diabetes. Dietary GI is associated with the incidence of diabetes in middle-aged Japanese men. GI and B-cell function were independently associated with incidence of diabetes. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/21803381/Dietary_glycemic_index_and_risk_of_type_2_diabetes_mellitus_in_middle_aged_Japanese_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(11)00155-7 DB - PRIME DP - Unbound Medicine ER -