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Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity.
Biol Pharm Bull. 2011; 34(8):1194-7.BP

Abstract

Oxidative damage plays a critical role in many neurodegenerative diseases. Astrocytes are involved in supporting the survival and protection of neurons against oxidative damage. The dysfunction of antioxidant in astrocytes has been implicated in a variety of neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), spinalmuscularatrophy (SMA). The loss of motor neuron in spinal cord has been attributed to deterioration of astrocytes. The activation of antioxidantive function in astrocytes may serve as a therapeutic strategy for neurodegenerative diseases. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master transcriptional regulator of phase II antioxidantive genes. We report herein that curcumin significantly activates Nrf2 target genes in primary spinal cord astrocytes, decreases the level of intracellular reactive oxygen species (ROS), and attenuates oxidative damage and mitochondrial dysfunction.

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Authors+Show Affiliations

Jiang H
Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, People’s Republic of China.
Tian X
No affiliation info available
Guo Y
No affiliation info available
Duan W
No affiliation info available
Bu H
No affiliation info available
Li C
No affiliation info available

MeSH

Amyotrophic Lateral SclerosisAnimalsAntioxidantsAstrocytesCurcumaCurcuminGene ExpressionMaleMiceMice, Inbred StrainsMitochondriaMuscular Atrophy, SpinalNF-E2-Related Factor 2Neurodegenerative DiseasesNeuroprotective AgentsOxidative StressPhytotherapyPlant ExtractsReactive Oxygen SpeciesSignal TransductionSpinal Cord

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21804205

Citation

Jiang, Hong, et al. "Activation of Nuclear Factor Erythroid 2-related Factor 2 Cytoprotective Signaling By Curcumin Protect Primary Spinal Cord Astrocytes Against Oxidative Toxicity." Biological & Pharmaceutical Bulletin, vol. 34, no. 8, 2011, pp. 1194-7.
Jiang H, Tian X, Guo Y, et al. Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity. Biol Pharm Bull. 2011;34(8):1194-7.
Jiang, H., Tian, X., Guo, Y., Duan, W., Bu, H., & Li, C. (2011). Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity. Biological & Pharmaceutical Bulletin, 34(8), 1194-7.
Jiang H, et al. Activation of Nuclear Factor Erythroid 2-related Factor 2 Cytoprotective Signaling By Curcumin Protect Primary Spinal Cord Astrocytes Against Oxidative Toxicity. Biol Pharm Bull. 2011;34(8):1194-7. PubMed PMID: 21804205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity. AU - Jiang,Hong, AU - Tian,Xinying, AU - Guo,Yansu, AU - Duan,Weisong, AU - Bu,Hui, AU - Li,Chunyan, PY - 2011/8/2/entrez PY - 2011/8/2/pubmed PY - 2012/3/1/medline SP - 1194 EP - 7 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 34 IS - 8 N2 - Oxidative damage plays a critical role in many neurodegenerative diseases. Astrocytes are involved in supporting the survival and protection of neurons against oxidative damage. The dysfunction of antioxidant in astrocytes has been implicated in a variety of neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), spinalmuscularatrophy (SMA). The loss of motor neuron in spinal cord has been attributed to deterioration of astrocytes. The activation of antioxidantive function in astrocytes may serve as a therapeutic strategy for neurodegenerative diseases. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master transcriptional regulator of phase II antioxidantive genes. We report herein that curcumin significantly activates Nrf2 target genes in primary spinal cord astrocytes, decreases the level of intracellular reactive oxygen species (ROS), and attenuates oxidative damage and mitochondrial dysfunction. SN - 1347-5215 UR - https://www.unboundmedicine.com/medline/citation/21804205/Activation_of_nuclear_factor_erythroid_2_related_factor_2_cytoprotective_signaling_by_curcumin_protect_primary_spinal_cord_astrocytes_against_oxidative_toxicity_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/34.1194?from=PubMed DB - PRIME DP - Unbound Medicine ER -