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Formulation study for orally disintegrating tablet using partly pregelatinized starch binder.
Chem Pharm Bull (Tokyo). 2011; 59(8):959-64.CP

Abstract

In this study, we aimed to design orally disintegrating tablets by employing a formulation design approach that enables the production of such tablets in the same facilities used for the production of solid dosage forms on an industrial scale. First, we examined the relationships between the types of binders used in the tablets and the properties of orally disintegrating tablets prepared by the wet granulation method. Results revealed that partly pregelatinized starch is a relatively suitable binder for orally disintegrating tablets as it also serves as a disintegrant. Next, we employed a central composite design for 2 factors, namely, corn starch and partly pregelatinized starch, in order to design granules suited for orally disintegrating tablets composed of D-mannitol, corn starch or partly pregelatinized starch. The effects of these 2 factors on 3 types of responses, namely, 50% granule size, compressing index and disintegrating index, were analyzed with a software package, and responses to changes in the factors were predicted. This study investigated the effects of binder type and binder content in orally disintegrating tablets, and provided evidence that the binder exerts a strong influence on tablet properties, and is therefore an important component of orally disintegrating tablets.

Authors+Show Affiliations

Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21804239

Citation

Mimura, Kazuki, et al. "Formulation Study for Orally Disintegrating Tablet Using Partly Pregelatinized Starch Binder." Chemical & Pharmaceutical Bulletin, vol. 59, no. 8, 2011, pp. 959-64.
Mimura K, Kanada K, Uchida S, et al. Formulation study for orally disintegrating tablet using partly pregelatinized starch binder. Chem Pharm Bull. 2011;59(8):959-64.
Mimura, K., Kanada, K., Uchida, S., Yamada, M., & Namiki, N. (2011). Formulation study for orally disintegrating tablet using partly pregelatinized starch binder. Chemical & Pharmaceutical Bulletin, 59(8), 959-64.
Mimura K, et al. Formulation Study for Orally Disintegrating Tablet Using Partly Pregelatinized Starch Binder. Chem Pharm Bull. 2011;59(8):959-64. PubMed PMID: 21804239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation study for orally disintegrating tablet using partly pregelatinized starch binder. AU - Mimura,Kazuki, AU - Kanada,Ken, AU - Uchida,Shinya, AU - Yamada,Masaki, AU - Namiki,Noriyuki, PY - 2011/8/2/entrez PY - 2011/8/2/pubmed PY - 2011/12/13/medline SP - 959 EP - 64 JF - Chemical & pharmaceutical bulletin JO - Chem. Pharm. Bull. VL - 59 IS - 8 N2 - In this study, we aimed to design orally disintegrating tablets by employing a formulation design approach that enables the production of such tablets in the same facilities used for the production of solid dosage forms on an industrial scale. First, we examined the relationships between the types of binders used in the tablets and the properties of orally disintegrating tablets prepared by the wet granulation method. Results revealed that partly pregelatinized starch is a relatively suitable binder for orally disintegrating tablets as it also serves as a disintegrant. Next, we employed a central composite design for 2 factors, namely, corn starch and partly pregelatinized starch, in order to design granules suited for orally disintegrating tablets composed of D-mannitol, corn starch or partly pregelatinized starch. The effects of these 2 factors on 3 types of responses, namely, 50% granule size, compressing index and disintegrating index, were analyzed with a software package, and responses to changes in the factors were predicted. This study investigated the effects of binder type and binder content in orally disintegrating tablets, and provided evidence that the binder exerts a strong influence on tablet properties, and is therefore an important component of orally disintegrating tablets. SN - 1347-5223 UR - https://www.unboundmedicine.com/medline/citation/21804239/Formulation_study_for_orally_disintegrating_tablet_using_partly_pregelatinized_starch_binder_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/cpb/59.959?from=PubMed DB - PRIME DP - Unbound Medicine ER -