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Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats.
Andrologia. 2012 May; 44 Suppl 1:396-409.A

Abstract

The present study investigated the effects of stinging nettle (Urtica dioica L.) (UD) on benign prostatic hyperplasia (BPH) induced by testosterone. In vitro studies were conducted to assess the 5α-reductase inhibitory potential of UD. Two biochemical markers viz., β-sitosterol and scopoletin, were isolated and characterised in the extracts utilising High-performance thin layer chromatographic, FTIR, NMR and overlain UV spectral studies. Hyperplasia was induced in rats by subcutaneous administration of testosterone (3 mg kg(-1) s.c.) for 28 days in all the groups except the vehicle-treated group. Simultaneous administration of petroleum ether and ethanolic extracts (10, 20 and 50 mg kg(-1) p.o.) and isolated β-sitosterol (10 and 20 mg kg(-1) p.o.) was undertaken. Finasteride was used as a positive control (1 mg kg(-1) p.o.). Measurement of prostate/body weight ratio, weekly urine output and serum testosterone levels, prostate-specific antigen levels (on day 28) and histological examinations carried out on prostates from each group led us to conclude that UD can be used as an effective drug for the management of BPH.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Doctor Hari Singh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India. aloknahata@gmail.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21806658

Citation

Nahata, A, and V K. Dixit. "Ameliorative Effects of Stinging Nettle (Urtica Dioica) On Testosterone-induced Prostatic Hyperplasia in Rats." Andrologia, vol. 44 Suppl 1, 2012, pp. 396-409.
Nahata A, Dixit VK. Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats. Andrologia. 2012;44 Suppl 1:396-409.
Nahata, A., & Dixit, V. K. (2012). Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats. Andrologia, 44 Suppl 1, 396-409. https://doi.org/10.1111/j.1439-0272.2011.01197.x
Nahata A, Dixit VK. Ameliorative Effects of Stinging Nettle (Urtica Dioica) On Testosterone-induced Prostatic Hyperplasia in Rats. Andrologia. 2012;44 Suppl 1:396-409. PubMed PMID: 21806658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats. AU - Nahata,A, AU - Dixit,V K, Y1 - 2011/08/02/ PY - 2011/8/3/entrez PY - 2011/8/3/pubmed PY - 2012/9/28/medline SP - 396 EP - 409 JF - Andrologia JO - Andrologia VL - 44 Suppl 1 N2 - The present study investigated the effects of stinging nettle (Urtica dioica L.) (UD) on benign prostatic hyperplasia (BPH) induced by testosterone. In vitro studies were conducted to assess the 5α-reductase inhibitory potential of UD. Two biochemical markers viz., β-sitosterol and scopoletin, were isolated and characterised in the extracts utilising High-performance thin layer chromatographic, FTIR, NMR and overlain UV spectral studies. Hyperplasia was induced in rats by subcutaneous administration of testosterone (3 mg kg(-1) s.c.) for 28 days in all the groups except the vehicle-treated group. Simultaneous administration of petroleum ether and ethanolic extracts (10, 20 and 50 mg kg(-1) p.o.) and isolated β-sitosterol (10 and 20 mg kg(-1) p.o.) was undertaken. Finasteride was used as a positive control (1 mg kg(-1) p.o.). Measurement of prostate/body weight ratio, weekly urine output and serum testosterone levels, prostate-specific antigen levels (on day 28) and histological examinations carried out on prostates from each group led us to conclude that UD can be used as an effective drug for the management of BPH. SN - 1439-0272 UR - https://www.unboundmedicine.com/medline/citation/21806658/Ameliorative_effects_of_stinging_nettle__Urtica_dioica__on_testosterone_induced_prostatic_hyperplasia_in_rats_ L2 - https://doi.org/10.1111/j.1439-0272.2011.01197.x DB - PRIME DP - Unbound Medicine ER -