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Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference.
Pharmacol Biochem Behav. 2011 Nov; 100(1):33-9.PB

Abstract

Cannabis is one of the drugs most commonly consumed in combination with ecstasy (3,4-methylenedioxymethamphetamine, MDMA). Although numerous studies have attempted to further our understanding of the role of the cannabinoid system in drug abuse, few have focused on how it influences the rewarding effects of MDMA. The aim of the present study was to evaluate the role of the CB1 cannabinoid receptor in vulnerability to reinstatement of a MDMA-induced conditioned place preference (CPP). Mice were first conditioned with 5mg/kg of MDMA. Once the preference had been extinguished, a priming dose of MDMA, alone or plus the CB1 cannabinoid agonist WIN 55,212-2 (0.1 and 0.5mg/kg) or the CB1 cannabinoid antagonist SR 141716A (0.3mg/kg), was administered on alternate days. The CB1 receptor antagonist, alone or with any of the priming doses of MDMA, induced reinstatement of the preference. In contrast, WIN 55,212-2 had no effect on reinstatement of the MDMA-induced CPP when administered alone, but potentiated the effects of subthreshold priming doses of MDMA. These results highlight the important role of the CB1 receptor in vulnerability to reinstatement of drug-seeking behavior and point to the importance of the endocannabinoid system in the addictive potential of MDMA.

Authors+Show Affiliations

Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21807018

Citation

Daza-Losada, M, et al. "Acute Blockade of CB1 Receptor Leads to Reinstatement of MDMA-induced Conditioned Place Preference." Pharmacology, Biochemistry, and Behavior, vol. 100, no. 1, 2011, pp. 33-9.
Daza-Losada M, Miñarro J, Aguilar MA, et al. Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference. Pharmacol Biochem Behav. 2011;100(1):33-9.
Daza-Losada, M., Miñarro, J., Aguilar, M. A., Valverde, O., & Rodríguez-Arias, M. (2011). Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference. Pharmacology, Biochemistry, and Behavior, 100(1), 33-9. https://doi.org/10.1016/j.pbb.2011.07.011
Daza-Losada M, et al. Acute Blockade of CB1 Receptor Leads to Reinstatement of MDMA-induced Conditioned Place Preference. Pharmacol Biochem Behav. 2011;100(1):33-9. PubMed PMID: 21807018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference. AU - Daza-Losada,M, AU - Miñarro,J, AU - Aguilar,M A, AU - Valverde,O, AU - Rodríguez-Arias,M, Y1 - 2011/07/23/ PY - 2011/06/01/received PY - 2011/07/11/revised PY - 2011/07/17/accepted PY - 2011/8/3/entrez PY - 2011/8/3/pubmed PY - 2012/7/24/medline SP - 33 EP - 9 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 100 IS - 1 N2 - Cannabis is one of the drugs most commonly consumed in combination with ecstasy (3,4-methylenedioxymethamphetamine, MDMA). Although numerous studies have attempted to further our understanding of the role of the cannabinoid system in drug abuse, few have focused on how it influences the rewarding effects of MDMA. The aim of the present study was to evaluate the role of the CB1 cannabinoid receptor in vulnerability to reinstatement of a MDMA-induced conditioned place preference (CPP). Mice were first conditioned with 5mg/kg of MDMA. Once the preference had been extinguished, a priming dose of MDMA, alone or plus the CB1 cannabinoid agonist WIN 55,212-2 (0.1 and 0.5mg/kg) or the CB1 cannabinoid antagonist SR 141716A (0.3mg/kg), was administered on alternate days. The CB1 receptor antagonist, alone or with any of the priming doses of MDMA, induced reinstatement of the preference. In contrast, WIN 55,212-2 had no effect on reinstatement of the MDMA-induced CPP when administered alone, but potentiated the effects of subthreshold priming doses of MDMA. These results highlight the important role of the CB1 receptor in vulnerability to reinstatement of drug-seeking behavior and point to the importance of the endocannabinoid system in the addictive potential of MDMA. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/21807018/Acute_blockade_of_CB1_receptor_leads_to_reinstatement_of_MDMA_induced_conditioned_place_preference_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(11)00247-4 DB - PRIME DP - Unbound Medicine ER -