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Anti-inflammatory and anti-nociceptive activities of Sipunculus nudus L. extract.
J Ethnopharmacol. 2011 Oct 11; 137(3):1177-82.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Sipunculus nudus has long been employed as traditional Chinese medicine in folk remedies for the treatment of carbuncles, tuberculosis and nocturia, regulating the functions of stomach and spleen, as well as for the restoration to health in debilities caused by various pathogens and aging. Decoction of Sipunculus nudus has traditionally been used to remedy sternalgia in folk medicine.

AIM OF THE STUDY

This study aimed to assess the anti-inflammatory and anti-nociceptive activity of the water extract from Sipunculus nudus.

MATERIALS AND METHODS

The water extract from the body wall of Sipunculus nudus was obtained with the yield of 14.1%. The anti-inflammatory effect in six animal models and anti-nociceptive effect in two animal models of the water extract were evaluated by oral for the study.

RESULTS

Pretreatment with the extract (at the dose of 50, 100 and 200 mg/kg) produced significant dose-dependent anti-inflammatory and anti-nociceptive effects. At 200 mg/kg dose, the inhibition ratio of the extract on carrageenan-induced rat hind paw oedema, dextran-induced rat paw oedema, cotton pellet granuloma in rats, carrageenan-induced peritonitis and acetic acid-induced vascular permeability were 59.2%, 51.0%, 53.1%, 42.5%, 50.8%, better than that of indomethacin (5 mg/kg) 49.5%, 50%, 44.4%, 37.6%, 46.8%, respectively. The inhibition ratio of the extract (200 mg/kg dose) on xylene-induced mouse ear oedema was 61.5%, lower than 63.7% for indomethacin (5 mg/kg). At 200mg/kg, the extract decreased number of writhing 52.3% in acetic acid-induced writhing model and increased the response latency 25.24% in hot plate test.

CONCLUSIONS

The water extract from the body wall of Sipunculus nudus possesses excellent anti-inflammatory activity as well as peripheral and central analgesic properties.

Links

Publisher Full Text

Authors+Show Affiliations

Zhang CX
Department of Marine Science, Qinzhou University, 89 Xihuan South Road, Qinzhou 535000, China. zcxocean@gmail.com
Dai ZR
No affiliation info available
Cai QX
No affiliation info available

MeSH

Acetic AcidAdministration, OralAnalgesicsAnimalsAnti-Inflammatory AgentsCapillary PermeabilityCarrageenanCotton FiberDextransDisease Models, AnimalDose-Response Relationship, DrugEdemaGranuloma, Foreign-BodyMedicine, Chinese TraditionalMiceMotor ActivityNematodaOrganotherapyPainPain ThresholdPeritonitisRatsRats, WistarXylenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21807085

Citation

Zhang, Chen-Xiao, et al. "Anti-inflammatory and Anti-nociceptive Activities of Sipunculus Nudus L. Extract." Journal of Ethnopharmacology, vol. 137, no. 3, 2011, pp. 1177-82.
Zhang CX, Dai ZR, Cai QX. Anti-inflammatory and anti-nociceptive activities of Sipunculus nudus L. extract. J Ethnopharmacol. 2011;137(3):1177-82.
Zhang, C. X., Dai, Z. R., & Cai, Q. X. (2011). Anti-inflammatory and anti-nociceptive activities of Sipunculus nudus L. extract. Journal of Ethnopharmacology, 137(3), 1177-82. https://doi.org/10.1016/j.jep.2011.07.039
Zhang CX, Dai ZR, Cai QX. Anti-inflammatory and Anti-nociceptive Activities of Sipunculus Nudus L. Extract. J Ethnopharmacol. 2011 Oct 11;137(3):1177-82. PubMed PMID: 21807085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and anti-nociceptive activities of Sipunculus nudus L. extract. AU - Zhang,Chen-Xiao, AU - Dai,Zi-Ru, AU - Cai,Qiu-Xing, Y1 - 2011/07/22/ PY - 2011/02/24/received PY - 2011/06/02/revised PY - 2011/07/07/accepted PY - 2011/8/3/entrez PY - 2011/8/3/pubmed PY - 2012/2/15/medline SP - 1177 EP - 82 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Sipunculus nudus has long been employed as traditional Chinese medicine in folk remedies for the treatment of carbuncles, tuberculosis and nocturia, regulating the functions of stomach and spleen, as well as for the restoration to health in debilities caused by various pathogens and aging. Decoction of Sipunculus nudus has traditionally been used to remedy sternalgia in folk medicine. AIM OF THE STUDY: This study aimed to assess the anti-inflammatory and anti-nociceptive activity of the water extract from Sipunculus nudus. MATERIALS AND METHODS: The water extract from the body wall of Sipunculus nudus was obtained with the yield of 14.1%. The anti-inflammatory effect in six animal models and anti-nociceptive effect in two animal models of the water extract were evaluated by oral for the study. RESULTS: Pretreatment with the extract (at the dose of 50, 100 and 200 mg/kg) produced significant dose-dependent anti-inflammatory and anti-nociceptive effects. At 200 mg/kg dose, the inhibition ratio of the extract on carrageenan-induced rat hind paw oedema, dextran-induced rat paw oedema, cotton pellet granuloma in rats, carrageenan-induced peritonitis and acetic acid-induced vascular permeability were 59.2%, 51.0%, 53.1%, 42.5%, 50.8%, better than that of indomethacin (5 mg/kg) 49.5%, 50%, 44.4%, 37.6%, 46.8%, respectively. The inhibition ratio of the extract (200 mg/kg dose) on xylene-induced mouse ear oedema was 61.5%, lower than 63.7% for indomethacin (5 mg/kg). At 200mg/kg, the extract decreased number of writhing 52.3% in acetic acid-induced writhing model and increased the response latency 25.24% in hot plate test. CONCLUSIONS: The water extract from the body wall of Sipunculus nudus possesses excellent anti-inflammatory activity as well as peripheral and central analgesic properties. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21807085/Anti_inflammatory_and_anti_nociceptive_activities_of_Sipunculus_nudus_L__extract_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00515-0 DB - PRIME DP - Unbound Medicine ER -