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Elsholtzia ciliata inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-{kappa}B.
Exp Biol Med (Maywood). 2011 Sep; 236(9):1070-7.EB

Abstract

Mast cell-mediated allergic reaction is involved in many diseases such as asthma and allergic rhinitis. Therefore, discovery of drugs for the prevention or treatment of allergic disease is an important topic in human health. In this study, we evaluated the effects of water extract of Elsholtzia ciliata (Thunb.) Hyland (Labiatae) (WEEC) on mast cell-mediated allergic inflammation and studied the possible mechanisms of action. WEEC inhibited compound 48/80-induced systemic and immunoglobulin E-mediated local anaphylaxis, and serum histamine release in mice. WEEC reduced intracellular calcium levels and downstream histamine release from human mast cells (HMC-1) activated with phorbol 12-myristate 13-acetate and calcium ionophore A23187. In addition, WEEC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β and IL-6 in HMC-1. The inhibitory effect of WEEC on cytokine expression was nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK) dependent. Our results indicate that WEEC inhibits mast cell-mediated allergic inflammatory reactions by suppressing histamine release and proinflammatory cytokine expression, and involvement of calcium, NF-κB and p38 MAPK in these effects.

Authors+Show Affiliations

CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21807818

Citation

Kim, Hui-Hun, et al. "Elsholtzia Ciliata Inhibits Mast Cell-mediated Allergic Inflammation: Role of Calcium, P38 Mitogen-activated Protein Kinase and Nuclear Factor-{kappa}B." Experimental Biology and Medicine (Maywood, N.J.), vol. 236, no. 9, 2011, pp. 1070-7.
Kim HH, Yoo JS, Lee HS, et al. Elsholtzia ciliata inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-{kappa}B. Exp Biol Med (Maywood). 2011;236(9):1070-7.
Kim, H. H., Yoo, J. S., Lee, H. S., Kwon, T. K., Shin, T. Y., & Kim, S. H. (2011). Elsholtzia ciliata inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-{kappa}B. Experimental Biology and Medicine (Maywood, N.J.), 236(9), 1070-7. https://doi.org/10.1258/ebm.2011.011017
Kim HH, et al. Elsholtzia Ciliata Inhibits Mast Cell-mediated Allergic Inflammation: Role of Calcium, P38 Mitogen-activated Protein Kinase and Nuclear Factor-{kappa}B. Exp Biol Med (Maywood). 2011;236(9):1070-7. PubMed PMID: 21807818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elsholtzia ciliata inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-{kappa}B. AU - Kim,Hui-Hun, AU - Yoo,Jin-Su, AU - Lee,Hyun-Shik, AU - Kwon,Taeg Kyu, AU - Shin,Tae-Yong, AU - Kim,Sang-Hyun, Y1 - 2011/08/01/ PY - 2011/8/3/entrez PY - 2011/8/3/pubmed PY - 2011/11/4/medline SP - 1070 EP - 7 JF - Experimental biology and medicine (Maywood, N.J.) JO - Exp Biol Med (Maywood) VL - 236 IS - 9 N2 - Mast cell-mediated allergic reaction is involved in many diseases such as asthma and allergic rhinitis. Therefore, discovery of drugs for the prevention or treatment of allergic disease is an important topic in human health. In this study, we evaluated the effects of water extract of Elsholtzia ciliata (Thunb.) Hyland (Labiatae) (WEEC) on mast cell-mediated allergic inflammation and studied the possible mechanisms of action. WEEC inhibited compound 48/80-induced systemic and immunoglobulin E-mediated local anaphylaxis, and serum histamine release in mice. WEEC reduced intracellular calcium levels and downstream histamine release from human mast cells (HMC-1) activated with phorbol 12-myristate 13-acetate and calcium ionophore A23187. In addition, WEEC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β and IL-6 in HMC-1. The inhibitory effect of WEEC on cytokine expression was nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK) dependent. Our results indicate that WEEC inhibits mast cell-mediated allergic inflammatory reactions by suppressing histamine release and proinflammatory cytokine expression, and involvement of calcium, NF-κB and p38 MAPK in these effects. SN - 1535-3699 UR - https://www.unboundmedicine.com/medline/citation/21807818/Elsholtzia_ciliata_inhibits_mast_cell_mediated_allergic_inflammation:_role_of_calcium_p38_mitogen_activated_protein_kinase_and_nuclear_factor_{kappa}B_ L2 - https://journals.sagepub.com/doi/10.1258/ebm.2011.011017?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -