Tags

Type your tag names separated by a space and hit enter

Effects of cisapride on parameters of oesophageal motility and on the prolonged intraoesophageal pH test in infants with gastro-oesophageal reflux disease.
Gut 1990; 31(1):21-5Gut

Abstract

The effect of cisapride, a new gastrointestinal prokinetic drug, on oesophageal motility and acid reflux was studied in 14 children with gastro-oesophageal reflux disease, receiving either placebo or cisapride 0.15 mg/kg intravenously. Cisapride significantly (p less than 0.01) increased the lower oesophageal sphincter pressure (+124%), the amplitude (+84%) and duration (+24%) of oesophageal peristaltic waves, whereas the placebo treatment did not produce any changes. Subsequently, all 14 children underwent 24 hour oesophageal pH-monitoring before and after four weeks of treatment with oral cisapride 0.2 mg/kg tid given in addition to postural therapy and thickened feedings. The 24 hour intraoesophageal pH recordings and symptomatic scores were compared with those of 10 control patients treated only by postural therapy and thickened feedings. When compared with baseline pH data, cisapride significantly reduced the oesophageal acid exposure time, the mean duration of each reflux episode, the duration of the longest reflux episode and the number of long lasting reflux episodes; the number of reflux episodes was not influenced. The effect of cisapride was marked and consistent during fasting and sleep periods. Oesophageal acid exposure was reduced more significantly in patients given cisapride (-61%) than in controls (-24%; p less than 0.001). Symptom improvement was greater after four weeks of cisapride treatment (score reduction: 61%) than after postural and dietary therapy alone (score reduction: 42%; p less than 0.01). No adverse effects occurred. These findings suggest that cisapride is a valuable drug in the management of gastro-oesophageal reflux disease in children.

Authors+Show Affiliations

Department of Pediatrics, 2nd School of Medicine, University of Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2180792

Citation

Cucchiara, S, et al. "Effects of Cisapride On Parameters of Oesophageal Motility and On the Prolonged Intraoesophageal pH Test in Infants With Gastro-oesophageal Reflux Disease." Gut, vol. 31, no. 1, 1990, pp. 21-5.
Cucchiara S, Staiano A, Boccieri A, et al. Effects of cisapride on parameters of oesophageal motility and on the prolonged intraoesophageal pH test in infants with gastro-oesophageal reflux disease. Gut. 1990;31(1):21-5.
Cucchiara, S., Staiano, A., Boccieri, A., De Stefano, M., Capozzi, C., Manzi, G., ... Paone, F. M. (1990). Effects of cisapride on parameters of oesophageal motility and on the prolonged intraoesophageal pH test in infants with gastro-oesophageal reflux disease. Gut, 31(1), pp. 21-5.
Cucchiara S, et al. Effects of Cisapride On Parameters of Oesophageal Motility and On the Prolonged Intraoesophageal pH Test in Infants With Gastro-oesophageal Reflux Disease. Gut. 1990;31(1):21-5. PubMed PMID: 2180792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of cisapride on parameters of oesophageal motility and on the prolonged intraoesophageal pH test in infants with gastro-oesophageal reflux disease. AU - Cucchiara,S, AU - Staiano,A, AU - Boccieri,A, AU - De Stefano,M, AU - Capozzi,C, AU - Manzi,G, AU - Camerlingo,F, AU - Paone,F M, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 21 EP - 5 JF - Gut JO - Gut VL - 31 IS - 1 N2 - The effect of cisapride, a new gastrointestinal prokinetic drug, on oesophageal motility and acid reflux was studied in 14 children with gastro-oesophageal reflux disease, receiving either placebo or cisapride 0.15 mg/kg intravenously. Cisapride significantly (p less than 0.01) increased the lower oesophageal sphincter pressure (+124%), the amplitude (+84%) and duration (+24%) of oesophageal peristaltic waves, whereas the placebo treatment did not produce any changes. Subsequently, all 14 children underwent 24 hour oesophageal pH-monitoring before and after four weeks of treatment with oral cisapride 0.2 mg/kg tid given in addition to postural therapy and thickened feedings. The 24 hour intraoesophageal pH recordings and symptomatic scores were compared with those of 10 control patients treated only by postural therapy and thickened feedings. When compared with baseline pH data, cisapride significantly reduced the oesophageal acid exposure time, the mean duration of each reflux episode, the duration of the longest reflux episode and the number of long lasting reflux episodes; the number of reflux episodes was not influenced. The effect of cisapride was marked and consistent during fasting and sleep periods. Oesophageal acid exposure was reduced more significantly in patients given cisapride (-61%) than in controls (-24%; p less than 0.001). Symptom improvement was greater after four weeks of cisapride treatment (score reduction: 61%) than after postural and dietary therapy alone (score reduction: 42%; p less than 0.01). No adverse effects occurred. These findings suggest that cisapride is a valuable drug in the management of gastro-oesophageal reflux disease in children. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/2180792/Effects_of_cisapride_on_parameters_of_oesophageal_motility_and_on_the_prolonged_intraoesophageal_pH_test_in_infants_with_gastro_oesophageal_reflux_disease_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=2180792 DB - PRIME DP - Unbound Medicine ER -