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Investigating the effect of punch geometry on high speed tableting through radial die-wall pressure monitoring.
Pharm Dev Technol. 2013 Feb; 18(1):46-54.PD

Abstract

Dwell time mainly depends on punch geometry, so some tableting problems such as capping and lamination could occur at high speed compaction. Robust tools are required to monitor the interaction of punch tip and powder bed at these high speeds. Our aim was to investigate the effect of punch geometry (flat and standard concave) on powder compaction at high speed using radial die-wall pressure (RDWP) as a monitoring tool. Instrumented die guided by compaction simulation was applied for five materials with different compaction behaviors. Flat-faced punch showed higher residual, maximum die-wall pressures, and axial stress transmission than concave punches, p < 0.003. Moreover, flat-faced punches showed less friction upon ejection, p < 0.003. Flat compacts showed higher elastic recovery, tensile strength, and required less work of compaction than convex compacts, p < 0.05. RDWP monitoring was a useful tool to prove that flat-faced punch induced higher radial stresses and particle/particle interactions in comparison to concave punch.

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Authors+Show Affiliations

Abdel-Hamid S
Industrial Pharmacy Research Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. sameh.abdel-hamid@unibas.ch
Betz G
No affiliation info available

MeSH

Drug CompoundingElasticityExcipientsPharmaceutical PreparationsPowdersPressureTabletsTensile StrengthTime Factors

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21810067

Citation

Abdel-Hamid, Sameh, and Gabriele Betz. "Investigating the Effect of Punch Geometry On High Speed Tableting Through Radial Die-wall Pressure Monitoring." Pharmaceutical Development and Technology, vol. 18, no. 1, 2013, pp. 46-54.
Abdel-Hamid S, Betz G. Investigating the effect of punch geometry on high speed tableting through radial die-wall pressure monitoring. Pharm Dev Technol. 2013;18(1):46-54.
Abdel-Hamid, S., & Betz, G. (2013). Investigating the effect of punch geometry on high speed tableting through radial die-wall pressure monitoring. Pharmaceutical Development and Technology, 18(1), 46-54. https://doi.org/10.3109/10837450.2011.598163
Abdel-Hamid S, Betz G. Investigating the Effect of Punch Geometry On High Speed Tableting Through Radial Die-wall Pressure Monitoring. Pharm Dev Technol. 2013;18(1):46-54. PubMed PMID: 21810067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigating the effect of punch geometry on high speed tableting through radial die-wall pressure monitoring. AU - Abdel-Hamid,Sameh, AU - Betz,Gabriele, Y1 - 2011/08/03/ PY - 2011/8/4/entrez PY - 2011/8/4/pubmed PY - 2013/5/18/medline SP - 46 EP - 54 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 18 IS - 1 N2 - Dwell time mainly depends on punch geometry, so some tableting problems such as capping and lamination could occur at high speed compaction. Robust tools are required to monitor the interaction of punch tip and powder bed at these high speeds. Our aim was to investigate the effect of punch geometry (flat and standard concave) on powder compaction at high speed using radial die-wall pressure (RDWP) as a monitoring tool. Instrumented die guided by compaction simulation was applied for five materials with different compaction behaviors. Flat-faced punch showed higher residual, maximum die-wall pressures, and axial stress transmission than concave punches, p < 0.003. Moreover, flat-faced punches showed less friction upon ejection, p < 0.003. Flat compacts showed higher elastic recovery, tensile strength, and required less work of compaction than convex compacts, p < 0.05. RDWP monitoring was a useful tool to prove that flat-faced punch induced higher radial stresses and particle/particle interactions in comparison to concave punch. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/21810067/Investigating_the_effect_of_punch_geometry_on_high_speed_tableting_through_radial_die_wall_pressure_monitoring_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2011.598163 DB - PRIME DP - Unbound Medicine ER -