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Antibodies to lipoarabinomannan antigen in sooty mangabey monkeys experimentally inoculated with Mycobacterium leprae.
Int J Lepr Other Mycobact Dis. 1990 Mar; 58(1):65-72.IJ

Abstract

IgG and IgM antibody levels to mycobacterial lipoarabinomannan (LAM) antigen were determined by ELISA in eight sooty mangabey monkeys (Cercocebus atys) prior to and at intervals after experimental inoculation with Mycobacterium leprae. High levels of anti-LAM IgG were present before inoculation and increased thereafter in the five mangabeys that developed lepromatous (LL) forms of leprosy; lower levels of anti-LAM IgG were observed in two mangabeys that developed indeterminate leprosy and tuberculoid/neuritic leprosy, respectively, and in a mangabey that was leprosy resistant. IgM anti-LAM levels were near zero before M. leprae inoculation in all eight animals, rose significantly in only three LL-leprosy-susceptible animals after inoculation, and returned to near zero in all animals within 3 years. Anti-LAM antibody levels appear to be potentially valuable as an indicator of leprosy susceptibility, and when measured longitudinally together with antibody levels to M. leprae-specific phenolic glycolipid-I antigen, as a means to detect preclinical M. leprae infections in high-risk individuals.

Authors+Show Affiliations

Gormus BJ
Delta Regional Primate Research Center, Tulane University, Covington, Louisiana 70433.
Xu K
No affiliation info available
Meyers WM
No affiliation info available
Walsh GP
No affiliation info available
Levis WR
No affiliation info available
Meeker HC
No affiliation info available

MeSH

AnimalsAntibodies, BacterialCercopithecidaeDisease SusceptibilityEnzyme-Linked Immunosorbent AssayImmunity, InnateImmunoglobulin GImmunoglobulin MLeprosyLipopolysaccharidesMaleMycobacterium leprae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2181045

Citation

Gormus, B J., et al. "Antibodies to Lipoarabinomannan Antigen in Sooty Mangabey Monkeys Experimentally Inoculated With Mycobacterium Leprae." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 58, no. 1, 1990, pp. 65-72.
Gormus BJ, Xu K, Meyers WM, et al. Antibodies to lipoarabinomannan antigen in sooty mangabey monkeys experimentally inoculated with Mycobacterium leprae. Int J Lepr Other Mycobact Dis. 1990;58(1):65-72.
Gormus, B. J., Xu, K., Meyers, W. M., Walsh, G. P., Levis, W. R., & Meeker, H. C. (1990). Antibodies to lipoarabinomannan antigen in sooty mangabey monkeys experimentally inoculated with Mycobacterium leprae. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 58(1), 65-72.
Gormus BJ, et al. Antibodies to Lipoarabinomannan Antigen in Sooty Mangabey Monkeys Experimentally Inoculated With Mycobacterium Leprae. Int J Lepr Other Mycobact Dis. 1990;58(1):65-72. PubMed PMID: 2181045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibodies to lipoarabinomannan antigen in sooty mangabey monkeys experimentally inoculated with Mycobacterium leprae. AU - Gormus,B J, AU - Xu,K, AU - Meyers,W M, AU - Walsh,G P, AU - Levis,W R, AU - Meeker,H C, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 65 EP - 72 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 58 IS - 1 N2 - IgG and IgM antibody levels to mycobacterial lipoarabinomannan (LAM) antigen were determined by ELISA in eight sooty mangabey monkeys (Cercocebus atys) prior to and at intervals after experimental inoculation with Mycobacterium leprae. High levels of anti-LAM IgG were present before inoculation and increased thereafter in the five mangabeys that developed lepromatous (LL) forms of leprosy; lower levels of anti-LAM IgG were observed in two mangabeys that developed indeterminate leprosy and tuberculoid/neuritic leprosy, respectively, and in a mangabey that was leprosy resistant. IgM anti-LAM levels were near zero before M. leprae inoculation in all eight animals, rose significantly in only three LL-leprosy-susceptible animals after inoculation, and returned to near zero in all animals within 3 years. Anti-LAM antibody levels appear to be potentially valuable as an indicator of leprosy susceptibility, and when measured longitudinally together with antibody levels to M. leprae-specific phenolic glycolipid-I antigen, as a means to detect preclinical M. leprae infections in high-risk individuals. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/2181045/Antibodies_to_lipoarabinomannan_antigen_in_sooty_mangabey_monkeys_experimentally_inoculated_with_Mycobacterium_leprae_ DB - PRIME DP - Unbound Medicine ER -