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Hereditary colon cancer syndromes.
Semin Oncol. 2011 Aug; 38(4):490-9.SO

Abstract

Colon cancer is associated with a family history in up to 25% of cases. As many as 5% are associated with an established hereditary syndrome, demonstrating the profound influence of inheritable genetic mechanisms in the development of this disease. These syndromes confer a diverse spectrum of risk, age of presentation, endoscopic and histological findings, extracolonic manifestations, and modes of inheritance. As the molecular characteristics of these disorders become better described, enhanced genotype-phenotype correlations may offer a more targeted approach to diagnosis, screening, and surveillance. While the strategies for diagnosis and management of familial adenomatous polyposis (FAP) and Lynch syndrome are more established, the approach to newly recognized syndromes such as MUTYH-associated polyposis (MAP) and hyperplastic polyposis syndromes continues to evolve. Effective cancer prevention in affected individuals and at-risk family members first requires timely recognition of these hereditary colon cancer syndromes followed by integration of genetic testing and clinical examinations.

Authors+Show Affiliations

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21810508

Citation

Gala, Manish, and Daniel C. Chung. "Hereditary Colon Cancer Syndromes." Seminars in Oncology, vol. 38, no. 4, 2011, pp. 490-9.
Gala M, Chung DC. Hereditary colon cancer syndromes. Semin Oncol. 2011;38(4):490-9.
Gala, M., & Chung, D. C. (2011). Hereditary colon cancer syndromes. Seminars in Oncology, 38(4), 490-9. https://doi.org/10.1053/j.seminoncol.2011.05.003
Gala M, Chung DC. Hereditary Colon Cancer Syndromes. Semin Oncol. 2011;38(4):490-9. PubMed PMID: 21810508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary colon cancer syndromes. AU - Gala,Manish, AU - Chung,Daniel C, PY - 2011/8/4/entrez PY - 2011/8/4/pubmed PY - 2011/10/1/medline SP - 490 EP - 9 JF - Seminars in oncology JO - Semin. Oncol. VL - 38 IS - 4 N2 - Colon cancer is associated with a family history in up to 25% of cases. As many as 5% are associated with an established hereditary syndrome, demonstrating the profound influence of inheritable genetic mechanisms in the development of this disease. These syndromes confer a diverse spectrum of risk, age of presentation, endoscopic and histological findings, extracolonic manifestations, and modes of inheritance. As the molecular characteristics of these disorders become better described, enhanced genotype-phenotype correlations may offer a more targeted approach to diagnosis, screening, and surveillance. While the strategies for diagnosis and management of familial adenomatous polyposis (FAP) and Lynch syndrome are more established, the approach to newly recognized syndromes such as MUTYH-associated polyposis (MAP) and hyperplastic polyposis syndromes continues to evolve. Effective cancer prevention in affected individuals and at-risk family members first requires timely recognition of these hereditary colon cancer syndromes followed by integration of genetic testing and clinical examinations. SN - 1532-8708 UR - https://www.unboundmedicine.com/medline/citation/21810508/Hereditary_colon_cancer_syndromes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0093-7754(11)00149-7 DB - PRIME DP - Unbound Medicine ER -