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Nutrients and genetic variation involved in one-carbon metabolism and Hodgkin lymphoma risk: a population-based case-control study.
Am J Epidemiol 2011; 174(7):816-27AJ

Abstract

Nutritional and genetic determinants of the one-carbon metabolism pathway have been related to risk of malignant lymphomas, but little is known about their associations with Hodgkin lymphoma risk specifically. The authors examined nutrient intake (folate, vitamin B(2), vitamin B(6), vitamin B(12), methionine) and multivitamin use among 497 Hodgkin lymphoma patients and 638 population-based controls (Massachusetts and Connecticut, 1997-2000), and genetic variation (MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, SHMT1 1420C>T, TYMS 1494del6) and gene-diet interactions in a subset. Unconditional logistic regression was used to calculate multivariable odds ratios and 95% confidence intervals. Hodgkin lymphoma risk was not associated with total nutrient intake or intake from food alone (excluding supplements). Multivitamin use (odds ratio (OR) = 1.46, 95% CI: 1.09, 1.96), total vitamin B(6) (OR(quartile 4 vs. 1) = 1.62) (P(trend) = 0.03), and total vitamin B(12) (OR(quartile 4 vs. 1) = 1.75) (P(trend) = 0.02) intakes were positively associated with risk of Epstein-Barr virus-negative, but not -positive, disease. The 5 genetic variants were not significantly associated with Hodgkin lymphoma risk; no significant gene-diet interactions were observed after Bonferroni correction. Study findings do not support a strong role for nutrients and genetic variation in the one-carbon metabolism pathway in susceptibility to Hodgkin lymphoma. Associations between diet and risk of Epstein-Barr virus-negative disease require confirmation in other populations.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. jkasperz@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21810727

Citation

Kasperzyk, Julie L., et al. "Nutrients and Genetic Variation Involved in One-carbon Metabolism and Hodgkin Lymphoma Risk: a Population-based Case-control Study." American Journal of Epidemiology, vol. 174, no. 7, 2011, pp. 816-27.
Kasperzyk JL, Chang ET, Birmann BM, et al. Nutrients and genetic variation involved in one-carbon metabolism and Hodgkin lymphoma risk: a population-based case-control study. Am J Epidemiol. 2011;174(7):816-27.
Kasperzyk, J. L., Chang, E. T., Birmann, B. M., Kraft, P., Zheng, T., & Mueller, N. E. (2011). Nutrients and genetic variation involved in one-carbon metabolism and Hodgkin lymphoma risk: a population-based case-control study. American Journal of Epidemiology, 174(7), pp. 816-27. doi:10.1093/aje/kwr190.
Kasperzyk JL, et al. Nutrients and Genetic Variation Involved in One-carbon Metabolism and Hodgkin Lymphoma Risk: a Population-based Case-control Study. Am J Epidemiol. 2011 Oct 1;174(7):816-27. PubMed PMID: 21810727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrients and genetic variation involved in one-carbon metabolism and Hodgkin lymphoma risk: a population-based case-control study. AU - Kasperzyk,Julie L, AU - Chang,Ellen T, AU - Birmann,Brenda M, AU - Kraft,Peter, AU - Zheng,Tongzhang, AU - Mueller,Nancy E, Y1 - 2011/08/01/ PY - 2011/8/4/entrez PY - 2011/8/4/pubmed PY - 2011/11/9/medline SP - 816 EP - 27 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 174 IS - 7 N2 - Nutritional and genetic determinants of the one-carbon metabolism pathway have been related to risk of malignant lymphomas, but little is known about their associations with Hodgkin lymphoma risk specifically. The authors examined nutrient intake (folate, vitamin B(2), vitamin B(6), vitamin B(12), methionine) and multivitamin use among 497 Hodgkin lymphoma patients and 638 population-based controls (Massachusetts and Connecticut, 1997-2000), and genetic variation (MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, SHMT1 1420C>T, TYMS 1494del6) and gene-diet interactions in a subset. Unconditional logistic regression was used to calculate multivariable odds ratios and 95% confidence intervals. Hodgkin lymphoma risk was not associated with total nutrient intake or intake from food alone (excluding supplements). Multivitamin use (odds ratio (OR) = 1.46, 95% CI: 1.09, 1.96), total vitamin B(6) (OR(quartile 4 vs. 1) = 1.62) (P(trend) = 0.03), and total vitamin B(12) (OR(quartile 4 vs. 1) = 1.75) (P(trend) = 0.02) intakes were positively associated with risk of Epstein-Barr virus-negative, but not -positive, disease. The 5 genetic variants were not significantly associated with Hodgkin lymphoma risk; no significant gene-diet interactions were observed after Bonferroni correction. Study findings do not support a strong role for nutrients and genetic variation in the one-carbon metabolism pathway in susceptibility to Hodgkin lymphoma. Associations between diet and risk of Epstein-Barr virus-negative disease require confirmation in other populations. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/21810727/Nutrients_and_genetic_variation_involved_in_one_carbon_metabolism_and_Hodgkin_lymphoma_risk:_a_population_based_case_control_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwr190 DB - PRIME DP - Unbound Medicine ER -