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Comparison of standard automated perimetry, frequency-doubling technology perimetry, and short-wavelength automated perimetry for detection of glaucoma.
Invest Ophthalmol Vis Sci. 2011 Sep 21; 52(10):7325-31.IO

Abstract

PURPOSE

To compare the performance of standard automated perimetry (SAP), frequency-doubling technology (FDT) perimetry, and short-wavelength automated perimetry (SWAP) in detecting glaucoma.

METHODS

One hundred thirty-two eyes of 95 glaucoma patients and 37 normal subjects had retinal nerve fiber layer (RNFL) imaging and visual field testing by SAP, Matrix FDT perimetry, and Swedish interactive thresholding algorithm (SITA) SWAP at the same visit (all perimeters by Carl Zeiss Meditec, Inc., Dublin, CA). Visual field defects were confirmed with two or more consecutive examinations by the same types of perimetry. Glaucoma was defined with the reference to the RNFL thickness deviation map score (≥ 4, glaucomatous; ≤ 2, normal). The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) of MD (mean deviation) and PSD (pattern standard deviation) of the perimetries were compared.

RESULTS

Taking all glaucoma patients into consideration, the sensitivity was highest for Matrix FDT perimetry (69%), followed by SAP (68%), and then SITA SWAP (59%). When the analysis included only patients with early glaucoma, the sensitivity decreased to 52%, 46%, and 34%, respectively, with a significant difference detected between Matrix FDT perimetry and SITA SWAP (P = 0.034). The specificity was ≥ 97% for all perimetries. The AUCs of MD and PSD followed a similar order, with Matrix FDT perimetry having the greatest AUC (0.89-0.94), followed by SAP (0.87-0.94), and then SITA SWAP (0.69-0.90). There were significant differences in sensitivities at 90% specificity between Matrix FDT perimetry and SITA SWAP (P ≤ 0.005 for MD; P ≤ 0.039 for PSD).

CONCLUSIONS

The performance for glaucoma detection was comparable between FDT perimetry and SAP. FDT perimetry had a higher sensitivity for detecting glaucoma than did SWAP at a comparable level of specificity.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21810975

Citation

Liu, Shu, et al. "Comparison of Standard Automated Perimetry, Frequency-doubling Technology Perimetry, and Short-wavelength Automated Perimetry for Detection of Glaucoma." Investigative Ophthalmology & Visual Science, vol. 52, no. 10, 2011, pp. 7325-31.
Liu S, Lam S, Weinreb RN, et al. Comparison of standard automated perimetry, frequency-doubling technology perimetry, and short-wavelength automated perimetry for detection of glaucoma. Invest Ophthalmol Vis Sci. 2011;52(10):7325-31.
Liu, S., Lam, S., Weinreb, R. N., Ye, C., Cheung, C. Y., Lai, G., Lam, D. S., & Leung, C. K. (2011). Comparison of standard automated perimetry, frequency-doubling technology perimetry, and short-wavelength automated perimetry for detection of glaucoma. Investigative Ophthalmology & Visual Science, 52(10), 7325-31. https://doi.org/10.1167/iovs.11-7795
Liu S, et al. Comparison of Standard Automated Perimetry, Frequency-doubling Technology Perimetry, and Short-wavelength Automated Perimetry for Detection of Glaucoma. Invest Ophthalmol Vis Sci. 2011 Sep 21;52(10):7325-31. PubMed PMID: 21810975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of standard automated perimetry, frequency-doubling technology perimetry, and short-wavelength automated perimetry for detection of glaucoma. AU - Liu,Shu, AU - Lam,Shi, AU - Weinreb,Robert N, AU - Ye,Cong, AU - Cheung,Carol Y, AU - Lai,Gilda, AU - Lam,Dennis Shun-Chiu, AU - Leung,Christopher Kai-Shun, Y1 - 2011/09/21/ PY - 2011/8/4/entrez PY - 2011/8/4/pubmed PY - 2011/12/13/medline SP - 7325 EP - 31 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 52 IS - 10 N2 - PURPOSE: To compare the performance of standard automated perimetry (SAP), frequency-doubling technology (FDT) perimetry, and short-wavelength automated perimetry (SWAP) in detecting glaucoma. METHODS: One hundred thirty-two eyes of 95 glaucoma patients and 37 normal subjects had retinal nerve fiber layer (RNFL) imaging and visual field testing by SAP, Matrix FDT perimetry, and Swedish interactive thresholding algorithm (SITA) SWAP at the same visit (all perimeters by Carl Zeiss Meditec, Inc., Dublin, CA). Visual field defects were confirmed with two or more consecutive examinations by the same types of perimetry. Glaucoma was defined with the reference to the RNFL thickness deviation map score (≥ 4, glaucomatous; ≤ 2, normal). The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) of MD (mean deviation) and PSD (pattern standard deviation) of the perimetries were compared. RESULTS: Taking all glaucoma patients into consideration, the sensitivity was highest for Matrix FDT perimetry (69%), followed by SAP (68%), and then SITA SWAP (59%). When the analysis included only patients with early glaucoma, the sensitivity decreased to 52%, 46%, and 34%, respectively, with a significant difference detected between Matrix FDT perimetry and SITA SWAP (P = 0.034). The specificity was ≥ 97% for all perimetries. The AUCs of MD and PSD followed a similar order, with Matrix FDT perimetry having the greatest AUC (0.89-0.94), followed by SAP (0.87-0.94), and then SITA SWAP (0.69-0.90). There were significant differences in sensitivities at 90% specificity between Matrix FDT perimetry and SITA SWAP (P ≤ 0.005 for MD; P ≤ 0.039 for PSD). CONCLUSIONS: The performance for glaucoma detection was comparable between FDT perimetry and SAP. FDT perimetry had a higher sensitivity for detecting glaucoma than did SWAP at a comparable level of specificity. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/21810975/Comparison_of_standard_automated_perimetry_frequency_doubling_technology_perimetry_and_short_wavelength_automated_perimetry_for_detection_of_glaucoma_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.11-7795 DB - PRIME DP - Unbound Medicine ER -