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Antiallodynic effects of propentofylline Elicited by interrupting spinal glial function in a rat model of bone cancer pain.
J Neurosci Res. 2011 Nov; 89(11):1877-86.JN

Abstract

The activation of microglia and astrocytes in the spinal cord is involved in the progress of cancer pain. Propentofylline (PPF), a glial modulating agent, alleviates pain hypersensitivity in neuropathic pain models. The present study investigated the potential roles of PPF in a preclinical rat model of bone caner pain established by inoculating Walker 256 cells into the left tibia. At day 9 postinoculation, single administration of PPF (10 μg/10 μl, i.t.) significantly but transiently suppressed mechanical allodynia induced by bone cancer. Repeated application of PPF (10 μg/10 μl, i.t., once daily from days 9 to 12) persistently relieved mechanical allodynia on the side ipsilateral to surgery. Immunohistochemistry and ELISA showed that microglia and astrocytes in the spinal cord were activated, and the production of glia-derived proinflammatory cytokines interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) markedly increased at day 12 postinoculation in the cancer group. Intrathecal injection of PPF (10 μg/10 μl) significantly inhibited the activation of spinal glial cells and the expression of proinflammatory cytokines. These results suggest that the glial modulating agent PPF has antiallodynic effects on bone cancer pain and has potential utility for clinical treatment of cancer pain.

Authors+Show Affiliations

Department of Anesthesiology, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21812015

Citation

Yao, Ming, et al. "Antiallodynic Effects of Propentofylline Elicited By Interrupting Spinal Glial Function in a Rat Model of Bone Cancer Pain." Journal of Neuroscience Research, vol. 89, no. 11, 2011, pp. 1877-86.
Yao M, Chang XY, Chu YX, et al. Antiallodynic effects of propentofylline Elicited by interrupting spinal glial function in a rat model of bone cancer pain. J Neurosci Res. 2011;89(11):1877-86.
Yao, M., Chang, X. Y., Chu, Y. X., Yang, J. P., Wang, L. N., Cao, H. Q., Liu, M. J., & Xu, Q. N. (2011). Antiallodynic effects of propentofylline Elicited by interrupting spinal glial function in a rat model of bone cancer pain. Journal of Neuroscience Research, 89(11), 1877-86. https://doi.org/10.1002/jnr.22711
Yao M, et al. Antiallodynic Effects of Propentofylline Elicited By Interrupting Spinal Glial Function in a Rat Model of Bone Cancer Pain. J Neurosci Res. 2011;89(11):1877-86. PubMed PMID: 21812015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiallodynic effects of propentofylline Elicited by interrupting spinal glial function in a rat model of bone cancer pain. AU - Yao,Ming, AU - Chang,Xiang-yang, AU - Chu,Yu-xia, AU - Yang,Jian-ping, AU - Wang,Li-na, AU - Cao,Hao-qiang, AU - Liu,Ming-juan, AU - Xu,Qi-nian, Y1 - 2011/08/02/ PY - 2010/12/28/received PY - 2011/04/02/revised PY - 2011/05/12/accepted PY - 2011/8/4/entrez PY - 2011/8/4/pubmed PY - 2012/1/21/medline SP - 1877 EP - 86 JF - Journal of neuroscience research JO - J Neurosci Res VL - 89 IS - 11 N2 - The activation of microglia and astrocytes in the spinal cord is involved in the progress of cancer pain. Propentofylline (PPF), a glial modulating agent, alleviates pain hypersensitivity in neuropathic pain models. The present study investigated the potential roles of PPF in a preclinical rat model of bone caner pain established by inoculating Walker 256 cells into the left tibia. At day 9 postinoculation, single administration of PPF (10 μg/10 μl, i.t.) significantly but transiently suppressed mechanical allodynia induced by bone cancer. Repeated application of PPF (10 μg/10 μl, i.t., once daily from days 9 to 12) persistently relieved mechanical allodynia on the side ipsilateral to surgery. Immunohistochemistry and ELISA showed that microglia and astrocytes in the spinal cord were activated, and the production of glia-derived proinflammatory cytokines interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) markedly increased at day 12 postinoculation in the cancer group. Intrathecal injection of PPF (10 μg/10 μl) significantly inhibited the activation of spinal glial cells and the expression of proinflammatory cytokines. These results suggest that the glial modulating agent PPF has antiallodynic effects on bone cancer pain and has potential utility for clinical treatment of cancer pain. SN - 1097-4547 UR - https://www.unboundmedicine.com/medline/citation/21812015/Antiallodynic_effects_of_propentofylline_Elicited_by_interrupting_spinal_glial_function_in_a_rat_model_of_bone_cancer_pain_ L2 - https://doi.org/10.1002/jnr.22711 DB - PRIME DP - Unbound Medicine ER -