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[Immunogenicity of influenza virus H5N2 vaccine strain samples produced by roller cultivation in media with plant derived components].

Abstract

AIM

Study in CBA line mice of immunogenicity of cold adapted reassortant influenza virus H5N2 vaccine strain samples produced in rollers in MDCK and Vero cell cultures by using plant derived components.

MATERIALS AND METHODS

Antibody levels in blood sera and nasal swabs, lungs and small intestine of experimental vaccine strain sample immunized mice were evaluated by using HI reaction in accordance with WHO recommendations.

RESULT

Reassortant vaccine strain A/17/duck/Potsdam/86/92 (H5N2) produced in MDCK and Vero cells by using plant derived components (rice and soy flour hydrolyzate and plant protease based nutrient medium) after intranasal immunization of mice induced local and humoral antibodies, and the latter not only against homologous virus, but also against highly pathogenic avian influenza virus strains A/ Chicken/Suzdalka/Nov-11/2005 and A/Chicken/Kurgan/05/2005.

CONCLUSION

Immunogenicity studies of reassortant influenza virus A/17/duck/Potsdam/86/92 (H5N2) vaccine strain samples cultivated in MDCK and Vero cells by using media with plant derived components in mice show high levels of humoral and secretory immunity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

rus

PubMed ID

21812141

Citation

Mazurkova, N A., et al. "[Immunogenicity of Influenza Virus H5N2 Vaccine Strain Samples Produced By Roller Cultivation in Media With Plant Derived Components]." Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii, 2011, pp. 48-52.
Mazurkova NA, Desheva IuA, Shishkina LN, et al. [Immunogenicity of influenza virus H5N2 vaccine strain samples produced by roller cultivation in media with plant derived components]. Zh Mikrobiol Epidemiol Immunobiol. 2011.
Mazurkova, N. A., Desheva, I. u. A., Shishkina, L. N., Stavskiĭ, E. A., & Rudenko, L. G. (2011). [Immunogenicity of influenza virus H5N2 vaccine strain samples produced by roller cultivation in media with plant derived components]. Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii, (3), 48-52.
Mazurkova NA, et al. [Immunogenicity of Influenza Virus H5N2 Vaccine Strain Samples Produced By Roller Cultivation in Media With Plant Derived Components]. Zh Mikrobiol Epidemiol Immunobiol. 2011 May-Jun;(3)48-52. PubMed PMID: 21812141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immunogenicity of influenza virus H5N2 vaccine strain samples produced by roller cultivation in media with plant derived components]. AU - Mazurkova,N A, AU - Desheva,Iu A, AU - Shishkina,L N, AU - Stavskiĭ,E A, AU - Rudenko,L G, PY - 2011/8/4/entrez PY - 2011/8/4/pubmed PY - 2011/9/7/medline SP - 48 EP - 52 JF - Zhurnal mikrobiologii, epidemiologii i immunobiologii JO - Zh Mikrobiol Epidemiol Immunobiol IS - 3 N2 - AIM: Study in CBA line mice of immunogenicity of cold adapted reassortant influenza virus H5N2 vaccine strain samples produced in rollers in MDCK and Vero cell cultures by using plant derived components. MATERIALS AND METHODS: Antibody levels in blood sera and nasal swabs, lungs and small intestine of experimental vaccine strain sample immunized mice were evaluated by using HI reaction in accordance with WHO recommendations. RESULT: Reassortant vaccine strain A/17/duck/Potsdam/86/92 (H5N2) produced in MDCK and Vero cells by using plant derived components (rice and soy flour hydrolyzate and plant protease based nutrient medium) after intranasal immunization of mice induced local and humoral antibodies, and the latter not only against homologous virus, but also against highly pathogenic avian influenza virus strains A/ Chicken/Suzdalka/Nov-11/2005 and A/Chicken/Kurgan/05/2005. CONCLUSION: Immunogenicity studies of reassortant influenza virus A/17/duck/Potsdam/86/92 (H5N2) vaccine strain samples cultivated in MDCK and Vero cells by using media with plant derived components in mice show high levels of humoral and secretory immunity. SN - 0372-9311 UR - https://www.unboundmedicine.com/medline/citation/21812141/[Immunogenicity_of_influenza_virus_H5N2_vaccine_strain_samples_produced_by_roller_cultivation_in_media_with_plant_derived_components]_ L2 - https://medlineplus.gov/flushot.html DB - PRIME DP - Unbound Medicine ER -