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Increased familiarity of intellectual deficits in early-onset schizophrenia spectrum disorders.
World J Biol Psychiatry 2012; 13(7):493-500WJ

Abstract

OBJECTIVES

Early-onset schizophrenia is considered to be neurobiologically similar to adult-onset forms, although it represents a more severe expression of the disorder. In the present study, we explored putative larger familial vulnerability of intellectual impairments in early-onset schizophrenia spectrum disorders (EOS) when compared to adult-onset (AOS) families.

METHODS

A sample of 340 subjects including schizophrenia spectrum disorder patients, their first degree relatives and age-matched healthy controls was assessed on intelligence quotient (IQ). We used linear regression analysis and intraclass correlation coefficients (ICC) to explore familial aggregation of IQ across age at onset groups.

RESULTS

The relationship between IQ level of patients and their first-degree relatives showed positive linear association (β = 0.43, P < 0.01). High significant familial aggregation was found for intelligence quotient in EOS families (ICC = 0.618, P < 0.01), while AOS families responded to lower estimates (ICC = 0.204, P = 0.26; between ICC comparison z = 1.993, P < 0.05).

CONCLUSIONS

High aggregation of intellectual performance in the EOS group suggests larger familial vulnerability in early-onset forms of the disease when cognitive functions are considered. Within a continuum of psychopathology in schizophrenia spectrum disorders, specific genetic effects are discussed for distinct onset forms that might be in line with a neurodevelopmental model of the disease.

Authors+Show Affiliations

Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21812621

Citation

Goldberg, Ximena, et al. "Increased Familiarity of Intellectual Deficits in Early-onset Schizophrenia Spectrum Disorders." The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, vol. 13, no. 7, 2012, pp. 493-500.
Goldberg X, Fatjó-Vilas M, Muñoz MJ, et al. Increased familiarity of intellectual deficits in early-onset schizophrenia spectrum disorders. World J Biol Psychiatry. 2012;13(7):493-500.
Goldberg, X., Fatjó-Vilas, M., Muñoz, M. J., Campanera, S., Miret, S., Miñano, M. J., ... Fañanás, L. (2012). Increased familiarity of intellectual deficits in early-onset schizophrenia spectrum disorders. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, 13(7), pp. 493-500. doi:10.3109/15622975.2011.585661.
Goldberg X, et al. Increased Familiarity of Intellectual Deficits in Early-onset Schizophrenia Spectrum Disorders. World J Biol Psychiatry. 2012;13(7):493-500. PubMed PMID: 21812621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased familiarity of intellectual deficits in early-onset schizophrenia spectrum disorders. AU - Goldberg,Ximena, AU - Fatjó-Vilas,Mar, AU - Muñoz,M José, AU - Campanera,Sílvia, AU - Miret,Salvador, AU - Miñano,M José, AU - Aguilera,Mari, AU - Miralles,M Luisa, AU - Navarro,M Eulalia, AU - Lázaro,Luisa, AU - Guitart,Marc, AU - Barrantes-Vidal,Neus, AU - Fañanás,Lourdes, Y1 - 2011/08/03/ PY - 2011/8/5/entrez PY - 2011/8/5/pubmed PY - 2013/3/7/medline SP - 493 EP - 500 JF - The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry JO - World J. Biol. Psychiatry VL - 13 IS - 7 N2 - OBJECTIVES: Early-onset schizophrenia is considered to be neurobiologically similar to adult-onset forms, although it represents a more severe expression of the disorder. In the present study, we explored putative larger familial vulnerability of intellectual impairments in early-onset schizophrenia spectrum disorders (EOS) when compared to adult-onset (AOS) families. METHODS: A sample of 340 subjects including schizophrenia spectrum disorder patients, their first degree relatives and age-matched healthy controls was assessed on intelligence quotient (IQ). We used linear regression analysis and intraclass correlation coefficients (ICC) to explore familial aggregation of IQ across age at onset groups. RESULTS: The relationship between IQ level of patients and their first-degree relatives showed positive linear association (β = 0.43, P < 0.01). High significant familial aggregation was found for intelligence quotient in EOS families (ICC = 0.618, P < 0.01), while AOS families responded to lower estimates (ICC = 0.204, P = 0.26; between ICC comparison z = 1.993, P < 0.05). CONCLUSIONS: High aggregation of intellectual performance in the EOS group suggests larger familial vulnerability in early-onset forms of the disease when cognitive functions are considered. Within a continuum of psychopathology in schizophrenia spectrum disorders, specific genetic effects are discussed for distinct onset forms that might be in line with a neurodevelopmental model of the disease. SN - 1814-1412 UR - https://www.unboundmedicine.com/medline/citation/21812621/Increased_familiarity_of_intellectual_deficits_in_early_onset_schizophrenia_spectrum_disorders_ L2 - http://www.tandfonline.com/doi/full/10.3109/15622975.2011.585661 DB - PRIME DP - Unbound Medicine ER -