Tags

Type your tag names separated by a space and hit enter

Enhanced targeting efficiency of PLGA microspheres loaded with Lornoxicam for intra-articular administration.
Drug Deliv. 2011 Sep-Oct; 18(7):536-44.DD

Abstract

Owing to its rationale of targeting the drug to the site of action and minimizing systemic toxic effects of the drug, intra-articular drug delivery system has gained growing interests. In this study, emphasis was placed on intra-articular Lornoxicam-loaded PLGA microspheres (Lnxc-PLGA-MS) preparation and improving the targeting of lornoxicam (Lnxc) in knee joint. The microspheres were prepared by a process involving solid-in-oil-in-water(S/O/W) emulsion, and evaluated for physicochemical properties. Joint cavity's drug leakage into systemic circulation in rabbits was examined to define the drug stagnation. Meanwhile, drug retention in synovial fluid in rats was investigated to further validate the drug targeting. The microspheres were spherical as evidenced by the SEM photographs with mean size of 7.47 μm, and encapsulation efficiency was observed 82.22% along with drug loading 12.17%. DSC revealed that the drug in the microspheres existed in the phase of uncrystallization. The formulated microspheres could prolong the drug release up to 32 days in vitro. Comparing with animals injected with lornoxicam solution, the plasma drug concentration decreased in rabbits and retention time increased in rats' synovial fluid with intra-articular injections of microspheres, revealing good targeting efficiency. In conclusion, PLGA microspheres could be used to deliver lornoxicam following intra-articular administration for enhancing targeting efficiency.

Authors+Show Affiliations

The School of Pharmaceutical Science, Shandong University, 44 Wenhua Xi Road, Ji'nan, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21812757

Citation

Zhang, Zhiyue, et al. "Enhanced Targeting Efficiency of PLGA Microspheres Loaded With Lornoxicam for Intra-articular Administration." Drug Delivery, vol. 18, no. 7, 2011, pp. 536-44.
Zhang Z, Bi X, Li H, et al. Enhanced targeting efficiency of PLGA microspheres loaded with Lornoxicam for intra-articular administration. Drug Deliv. 2011;18(7):536-44.
Zhang, Z., Bi, X., Li, H., & Huang, G. (2011). Enhanced targeting efficiency of PLGA microspheres loaded with Lornoxicam for intra-articular administration. Drug Delivery, 18(7), 536-44. https://doi.org/10.3109/10717544.2011.596584
Zhang Z, et al. Enhanced Targeting Efficiency of PLGA Microspheres Loaded With Lornoxicam for Intra-articular Administration. Drug Deliv. 2011 Sep-Oct;18(7):536-44. PubMed PMID: 21812757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced targeting efficiency of PLGA microspheres loaded with Lornoxicam for intra-articular administration. AU - Zhang,Zhiyue, AU - Bi,Xiuli, AU - Li,Hui, AU - Huang,Guihua, Y1 - 2011/08/04/ PY - 2011/8/5/entrez PY - 2011/8/5/pubmed PY - 2012/1/12/medline SP - 536 EP - 44 JF - Drug delivery JO - Drug Deliv VL - 18 IS - 7 N2 - Owing to its rationale of targeting the drug to the site of action and minimizing systemic toxic effects of the drug, intra-articular drug delivery system has gained growing interests. In this study, emphasis was placed on intra-articular Lornoxicam-loaded PLGA microspheres (Lnxc-PLGA-MS) preparation and improving the targeting of lornoxicam (Lnxc) in knee joint. The microspheres were prepared by a process involving solid-in-oil-in-water(S/O/W) emulsion, and evaluated for physicochemical properties. Joint cavity's drug leakage into systemic circulation in rabbits was examined to define the drug stagnation. Meanwhile, drug retention in synovial fluid in rats was investigated to further validate the drug targeting. The microspheres were spherical as evidenced by the SEM photographs with mean size of 7.47 μm, and encapsulation efficiency was observed 82.22% along with drug loading 12.17%. DSC revealed that the drug in the microspheres existed in the phase of uncrystallization. The formulated microspheres could prolong the drug release up to 32 days in vitro. Comparing with animals injected with lornoxicam solution, the plasma drug concentration decreased in rabbits and retention time increased in rats' synovial fluid with intra-articular injections of microspheres, revealing good targeting efficiency. In conclusion, PLGA microspheres could be used to deliver lornoxicam following intra-articular administration for enhancing targeting efficiency. SN - 1521-0464 UR - https://www.unboundmedicine.com/medline/citation/21812757/Enhanced_targeting_efficiency_of_PLGA_microspheres_loaded_with_Lornoxicam_for_intra_articular_administration_ L2 - http://www.tandfonline.com/doi/full/10.3109/10717544.2011.596584 DB - PRIME DP - Unbound Medicine ER -