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Clinical significance of tumor-infiltrating FOXP3+ T cells in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma.
Cancer Sci 2011; 102(11):1972-6CS

Abstract

We evaluated the association between tumor-infiltrating FOXP3+ T cells and clinical outcomes in patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue type (OAML). Pretreatment formalin-fixed paraffin-embedded tissues from 42 patients with OAML were stained with 236A/E7 anti-FOXP3 murine monoclonal antibody as well as CD3, CD4 and CD8 antibodies. The amount of FOXP3+ T cells was numerically quantified using an image analysis program. Front-line treatments were as follows: combination chemotherapy (n = 25); radiotherapy (n = 9); doxycycline (n = 6); and wait and see (n = 2). Complete response (CR) was observed in 20 (50%) of 40 evaluable patients. Median progression-free survival (PFS) was 50 months. A high number of FOXP3+ T cells (n = 21, ≥ 180/0.58 mm(2)) showed a higher CR rate (33%vs 71%, P = 0.013) and tendency towards prolonged PFS (48 vs 67 months, P = 0.110). In the combination chemotherapy group, a high number of FOXP3+ T cells was significantly associated with a higher CR rate (29%vs 82%, P = 0.008) and prolonged PFS (17 vs 79 months, P = 0.003). A high number of tumor-infiltrating FOXP3+ T cells correlates with a favorable clinical outcome in OAML patients.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21812857

Citation

Kim, Ki Hwan, et al. "Clinical Significance of Tumor-infiltrating FOXP3+ T Cells in Patients With Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma." Cancer Science, vol. 102, no. 11, 2011, pp. 1972-6.
Kim KH, Kim TM, Go H, et al. Clinical significance of tumor-infiltrating FOXP3+ T cells in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma. Cancer Sci. 2011;102(11):1972-6.
Kim, K. H., Kim, T. M., Go, H., Kim, W. Y., Jeon, Y. K., Lee, S. H., ... Heo, D. S. (2011). Clinical significance of tumor-infiltrating FOXP3+ T cells in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma. Cancer Science, 102(11), pp. 1972-6. doi:10.1111/j.1349-7006.2011.02051.x.
Kim KH, et al. Clinical Significance of Tumor-infiltrating FOXP3+ T Cells in Patients With Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma. Cancer Sci. 2011;102(11):1972-6. PubMed PMID: 21812857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical significance of tumor-infiltrating FOXP3+ T cells in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma. AU - Kim,Ki Hwan, AU - Kim,Tae Min, AU - Go,Heounjeong, AU - Kim,Wook Youn, AU - Jeon,Yoon Kyung, AU - Lee,Se-Hoon, AU - Kim,Dong-Wan, AU - Khwarg,Sang In, AU - Kim,Chul-Woo, AU - Heo,Dae Seog, Y1 - 2011/09/06/ PY - 2011/8/5/entrez PY - 2011/8/5/pubmed PY - 2011/12/20/medline SP - 1972 EP - 6 JF - Cancer science JO - Cancer Sci. VL - 102 IS - 11 N2 - We evaluated the association between tumor-infiltrating FOXP3+ T cells and clinical outcomes in patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue type (OAML). Pretreatment formalin-fixed paraffin-embedded tissues from 42 patients with OAML were stained with 236A/E7 anti-FOXP3 murine monoclonal antibody as well as CD3, CD4 and CD8 antibodies. The amount of FOXP3+ T cells was numerically quantified using an image analysis program. Front-line treatments were as follows: combination chemotherapy (n = 25); radiotherapy (n = 9); doxycycline (n = 6); and wait and see (n = 2). Complete response (CR) was observed in 20 (50%) of 40 evaluable patients. Median progression-free survival (PFS) was 50 months. A high number of FOXP3+ T cells (n = 21, ≥ 180/0.58 mm(2)) showed a higher CR rate (33%vs 71%, P = 0.013) and tendency towards prolonged PFS (48 vs 67 months, P = 0.110). In the combination chemotherapy group, a high number of FOXP3+ T cells was significantly associated with a higher CR rate (29%vs 82%, P = 0.008) and prolonged PFS (17 vs 79 months, P = 0.003). A high number of tumor-infiltrating FOXP3+ T cells correlates with a favorable clinical outcome in OAML patients. SN - 1349-7006 UR - https://www.unboundmedicine.com/medline/citation/21812857/Clinical_significance_of_tumor_infiltrating_FOXP3+_T_cells_in_patients_with_ocular_adnexal_mucosa_associated_lymphoid_tissue_lymphoma_ L2 - https://doi.org/10.1111/j.1349-7006.2011.02051.x DB - PRIME DP - Unbound Medicine ER -