Tags

Type your tag names separated by a space and hit enter

Increased risk of end-stage renal disease in individuals with coeliac disease.

Abstract

OBJECTIVE

The prevalence of end-stage renal disease (ESRD) is increasing worldwide. Although increased levels of coeliac disease (CD) autoantibodies are often seen in renal disease, the importance of biopsy-verified CD for the risk of future ESRD is unclear. The aim of this study was therefore to investigate the risk of future ESRD in individuals with CD.

METHODS

This was a population-based prospective cohort study. 29,050 individuals with CD (Marsh III) were identified through small-intestinal biopsy reports obtained between July 1969 and February 2008 in Sweden's 28 pathology departments. ESRD was defined as the need for renal dialysis or renal transplant in accordance with the international classification of disease and procedure codes in Swedish patient registers. Using Cox regression, the risk of ESRD in individuals with CD compared with age- and sex-matched reference individuals was estimated.

RESULTS

During follow-up, 90 individuals with CD developed ESRD (expected count 31). This corresponded to a HR for ESRD of 2.87 (95% CI 2.22 to 3.71, p<0.001). Adjusting for diabetes mellitus had only a marginal effect on the risk estimate (HR 2.52, 95% CI 1.92 to 3.31). Excluding individuals with any urinary/renal disorder before study entry, the HR for ESRD in CD was 2.47 (95% CI 1.80 to 3.40). When restricting the outcome measure to ESRD confirmed by independent data from the Swedish Renal Registry (SRR), the risk estimate increased to 3.20 (95% CI 2.39 to 4.28).

CONCLUSION

This study indicates that individuals with biopsy-verified CD suffer increased risk of subsequent ESRD.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. adina.welander@ki.se

    , ,

    Source

    Gut 61:1 2012 Jan pg 64-8

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Biopsy
    Celiac Disease
    Child
    Child, Preschool
    Female
    Humans
    Incidence
    Infant
    Infant, Newborn
    Intestine, Small
    Kidney Failure, Chronic
    Male
    Middle Aged
    Prospective Studies
    Registries
    Risk
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21813475

    Citation

    Welander, Adina, et al. "Increased Risk of End-stage Renal Disease in Individuals With Coeliac Disease." Gut, vol. 61, no. 1, 2012, pp. 64-8.
    Welander A, Prütz KG, Fored M, et al. Increased risk of end-stage renal disease in individuals with coeliac disease. Gut. 2012;61(1):64-8.
    Welander, A., Prütz, K. G., Fored, M., & Ludvigsson, J. F. (2012). Increased risk of end-stage renal disease in individuals with coeliac disease. Gut, 61(1), pp. 64-8. doi:10.1136/gutjnl-2011-300134.
    Welander A, et al. Increased Risk of End-stage Renal Disease in Individuals With Coeliac Disease. Gut. 2012;61(1):64-8. PubMed PMID: 21813475.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Increased risk of end-stage renal disease in individuals with coeliac disease. AU - Welander,Adina, AU - Prütz,Karl-Göran, AU - Fored,Michael, AU - Ludvigsson,Jonas F, Y1 - 2011/08/03/ PY - 2011/8/5/entrez PY - 2011/8/5/pubmed PY - 2012/1/31/medline SP - 64 EP - 8 JF - Gut JO - Gut VL - 61 IS - 1 N2 - OBJECTIVE: The prevalence of end-stage renal disease (ESRD) is increasing worldwide. Although increased levels of coeliac disease (CD) autoantibodies are often seen in renal disease, the importance of biopsy-verified CD for the risk of future ESRD is unclear. The aim of this study was therefore to investigate the risk of future ESRD in individuals with CD. METHODS: This was a population-based prospective cohort study. 29,050 individuals with CD (Marsh III) were identified through small-intestinal biopsy reports obtained between July 1969 and February 2008 in Sweden's 28 pathology departments. ESRD was defined as the need for renal dialysis or renal transplant in accordance with the international classification of disease and procedure codes in Swedish patient registers. Using Cox regression, the risk of ESRD in individuals with CD compared with age- and sex-matched reference individuals was estimated. RESULTS: During follow-up, 90 individuals with CD developed ESRD (expected count 31). This corresponded to a HR for ESRD of 2.87 (95% CI 2.22 to 3.71, p<0.001). Adjusting for diabetes mellitus had only a marginal effect on the risk estimate (HR 2.52, 95% CI 1.92 to 3.31). Excluding individuals with any urinary/renal disorder before study entry, the HR for ESRD in CD was 2.47 (95% CI 1.80 to 3.40). When restricting the outcome measure to ESRD confirmed by independent data from the Swedish Renal Registry (SRR), the risk estimate increased to 3.20 (95% CI 2.39 to 4.28). CONCLUSION: This study indicates that individuals with biopsy-verified CD suffer increased risk of subsequent ESRD. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/21813475/Increased_risk_of_end_stage_renal_disease_in_individuals_with_coeliac_disease_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&amp;pmid=21813475 DB - PRIME DP - Unbound Medicine ER -