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An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile.
Org Biomol Chem. 2011 Oct 21; 9(20):7033-7.OB

Abstract

A three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile catalyzed by silver triflate under mild conditions is reported, which generates pyrazolo[5,1-a]isoquinolin-2-amines in good to excellent yields.

Authors+Show Affiliations

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21814677

Citation

Yu, Xingxin, et al. "An Efficient Approach to Pyrazolo[5,1-a]isoquinolin-2-amines Via a silver(I)-catalyzed Three-component Reaction of 2-alkynylbenzaldehyde, Sulfonohydrazide, and Nitrile." Organic & Biomolecular Chemistry, vol. 9, no. 20, 2011, pp. 7033-7.
Yu X, Yang Q, Lou H, et al. An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile. Org Biomol Chem. 2011;9(20):7033-7.
Yu, X., Yang, Q., Lou, H., Peng, Y., & Wu, J. (2011). An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile. Organic & Biomolecular Chemistry, 9(20), 7033-7. https://doi.org/10.1039/c1ob05917c
Yu X, et al. An Efficient Approach to Pyrazolo[5,1-a]isoquinolin-2-amines Via a silver(I)-catalyzed Three-component Reaction of 2-alkynylbenzaldehyde, Sulfonohydrazide, and Nitrile. Org Biomol Chem. 2011 Oct 21;9(20):7033-7. PubMed PMID: 21814677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile. AU - Yu,Xingxin, AU - Yang,Qin, AU - Lou,Honglei, AU - Peng,Yiyuan, AU - Wu,Jie, Y1 - 2011/08/03/ PY - 2011/8/5/entrez PY - 2011/8/5/pubmed PY - 2012/1/4/medline SP - 7033 EP - 7 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 9 IS - 20 N2 - A three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile catalyzed by silver triflate under mild conditions is reported, which generates pyrazolo[5,1-a]isoquinolin-2-amines in good to excellent yields. SN - 1477-0539 UR - https://www.unboundmedicine.com/medline/citation/21814677/An_efficient_approach_to_pyrazolo[51_a]isoquinolin_2_amines_via_a_silver_I__catalyzed_three_component_reaction_of_2_alkynylbenzaldehyde_sulfonohydrazide_and_nitrile_ L2 - https://doi.org/10.1039/c1ob05917c DB - PRIME DP - Unbound Medicine ER -