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An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile.
Org Biomol Chem. 2011 Oct 21; 9(20):7033-7.OB

Abstract

A three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile catalyzed by silver triflate under mild conditions is reported, which generates pyrazolo[5,1-a]isoquinolin-2-amines in good to excellent yields.

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Authors+Show Affiliations

Yu X
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
Yang Q
No affiliation info available
Lou H
No affiliation info available
Peng Y
No affiliation info available
Wu J
No affiliation info available

MeSH

AlkynesAminesBenzaldehydesCatalysisIsoquinolinesMolecular StructureNitrilesPyrazolesSilverThiadiazoles

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21814677

Citation

Yu, Xingxin, et al. "An Efficient Approach to Pyrazolo[5,1-a]isoquinolin-2-amines Via a silver(I)-catalyzed Three-component Reaction of 2-alkynylbenzaldehyde, Sulfonohydrazide, and Nitrile." Organic & Biomolecular Chemistry, vol. 9, no. 20, 2011, pp. 7033-7.
Yu X, Yang Q, Lou H, et al. An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile. Org Biomol Chem. 2011;9(20):7033-7.
Yu, X., Yang, Q., Lou, H., Peng, Y., & Wu, J. (2011). An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile. Organic & Biomolecular Chemistry, 9(20), 7033-7. https://doi.org/10.1039/c1ob05917c
Yu X, et al. An Efficient Approach to Pyrazolo[5,1-a]isoquinolin-2-amines Via a silver(I)-catalyzed Three-component Reaction of 2-alkynylbenzaldehyde, Sulfonohydrazide, and Nitrile. Org Biomol Chem. 2011 Oct 21;9(20):7033-7. PubMed PMID: 21814677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile. AU - Yu,Xingxin, AU - Yang,Qin, AU - Lou,Honglei, AU - Peng,Yiyuan, AU - Wu,Jie, Y1 - 2011/08/03/ PY - 2011/8/5/entrez PY - 2011/8/5/pubmed PY - 2012/1/4/medline SP - 7033 EP - 7 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 9 IS - 20 N2 - A three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile catalyzed by silver triflate under mild conditions is reported, which generates pyrazolo[5,1-a]isoquinolin-2-amines in good to excellent yields. SN - 1477-0539 UR - https://www.unboundmedicine.com/medline/citation/21814677/An_efficient_approach_to_pyrazolo[51_a]isoquinolin_2_amines_via_a_silver_I__catalyzed_three_component_reaction_of_2_alkynylbenzaldehyde_sulfonohydrazide_and_nitrile_ L2 - https://doi.org/10.1039/c1ob05917c DB - PRIME DP - Unbound Medicine ER -