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Chemical composition of Argentinean propolis collected in extreme regions and its relation with antimicrobial and antioxidant activities.
Nat Prod Commun 2011; 6(6):823-7NP

Abstract

This paper reveals, for the first time, the functional properties of propolis from an extreme region of Argentine (El Rincón, Province of Catamarca, Argentina), as well as the isolation and identification of bioactive compounds. The antioxidant activity was determined by the ABTS method and beta-carotene bleaching. The antibacterial activity was determined on methicillin resistant Staphylococcus aureus (MRSA) by the microdilution method and bioautographic assays. Twelve compounds were isolated and identified by NMR spectroscopy. The main bioactive compounds were 2',4'-dihydroxy-3'-methoxychalcone (3), 2',4'-dihydroxychalcone (9), 2',4',4-trihydroxy-6'- methoxychalcone (8), 5-hydroxy-4',7-dimethoxyflavone (4), 4',5-dihydroxy-3,7,8-trimethoxyflavone (10) and 7-hydroxy- 5,8-dimethoxyflavone (11). All compounds were active against clinical isolates (MIC50 10 microg/mL) and displayed antioxidant activity (SC50 values of 20 microg/mL). The MIC and SC50 values of the isolated compounds were lower than those obtained with crude propolis extracts, chloroform sub-extracts and isolated fractions.

Authors+Show Affiliations

Facultad de Bioquímica, Química y Farmacia, Ayacucho 471, Universidad Nacional de Tucumán, 4000 San Miguel de Tucumán, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21815419

Citation

Vera, Nancy, et al. "Chemical Composition of Argentinean Propolis Collected in Extreme Regions and Its Relation With Antimicrobial and Antioxidant Activities." Natural Product Communications, vol. 6, no. 6, 2011, pp. 823-7.
Vera N, Solorzano E, Ordoñez R, et al. Chemical composition of Argentinean propolis collected in extreme regions and its relation with antimicrobial and antioxidant activities. Nat Prod Commun. 2011;6(6):823-7.
Vera, N., Solorzano, E., Ordoñez, R., Maldonado, L., Bedascarrasbure, E., & Isla, M. I. (2011). Chemical composition of Argentinean propolis collected in extreme regions and its relation with antimicrobial and antioxidant activities. Natural Product Communications, 6(6), pp. 823-7.
Vera N, et al. Chemical Composition of Argentinean Propolis Collected in Extreme Regions and Its Relation With Antimicrobial and Antioxidant Activities. Nat Prod Commun. 2011;6(6):823-7. PubMed PMID: 21815419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition of Argentinean propolis collected in extreme regions and its relation with antimicrobial and antioxidant activities. AU - Vera,Nancy, AU - Solorzano,Eliana, AU - Ordoñez,Roxana, AU - Maldonado,Luis, AU - Bedascarrasbure,Enrique, AU - Isla,María I, PY - 2011/8/6/entrez PY - 2011/8/6/pubmed PY - 2011/9/9/medline SP - 823 EP - 7 JF - Natural product communications JO - Nat Prod Commun VL - 6 IS - 6 N2 - This paper reveals, for the first time, the functional properties of propolis from an extreme region of Argentine (El Rincón, Province of Catamarca, Argentina), as well as the isolation and identification of bioactive compounds. The antioxidant activity was determined by the ABTS method and beta-carotene bleaching. The antibacterial activity was determined on methicillin resistant Staphylococcus aureus (MRSA) by the microdilution method and bioautographic assays. Twelve compounds were isolated and identified by NMR spectroscopy. The main bioactive compounds were 2',4'-dihydroxy-3'-methoxychalcone (3), 2',4'-dihydroxychalcone (9), 2',4',4-trihydroxy-6'- methoxychalcone (8), 5-hydroxy-4',7-dimethoxyflavone (4), 4',5-dihydroxy-3,7,8-trimethoxyflavone (10) and 7-hydroxy- 5,8-dimethoxyflavone (11). All compounds were active against clinical isolates (MIC50 10 microg/mL) and displayed antioxidant activity (SC50 values of 20 microg/mL). The MIC and SC50 values of the isolated compounds were lower than those obtained with crude propolis extracts, chloroform sub-extracts and isolated fractions. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/21815419/Chemical_composition_of_Argentinean_propolis_collected_in_extreme_regions_and_its_relation_with_antimicrobial_and_antioxidant_activities_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -