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Endocrine and metabolic characteristics of polycystic ovary syndrome in Chinese women with different phenotypes.

Abstract

OBJECTIVE

The aim of this study was to describe the endocrine and metabolic characteristics of Chinese women with polycystic ovarian syndrome (PCOS) according to different phenotypes, including menstrual cycle pattern and body mass index (BMI).

DESIGN

Retrospective study.

PATIENT(S)

  A total of 3539 patients with PCOS and 590 controls were recruited from the Centre for Reproductive Medicine. Patients with PCOS were divided into three groups according to the characteristics of the menstrual cycle (amenorrhoea, oligomenorrhea and eumenorrhea) and the BMI (<25 kg/m(2) ; 25 ≤ and ≤ 30 kg/m(2) ; and BMI > 30 kg/m(2) ).

MEASUREMENTS

Waist circumference, hip circumference, weight, height, Ferriman-Gallwey score, and endocrine and metabolic variables were measured.

RESULTS

  The serum testosterone, luteinizing hormone (LH) and oral glucose tolerance test 2 h-glucose levels were increased in the amenorrhoea group (P < 0·05). The triglycerides (TG) and low-density lipoprotein-cholesterol (LDL) levels were the highest in the amenorrhoea group (P < 0·05). The same trend existed in total cholesterol and non- high-density lipoprotein-cholesterol (HDL) levels, although there was no statistical significance (P > 0·05). Subjects with a BMI<25 kg/m(2) had higher values of follicle stimulating hormone (FSH), LH, LH/FSH and prolactin (P < 0·001) than the other two groups. The levels of TG, LDL and non-HDL and the indices of glucose and insulin metabolism increased with the change in BMI (P < 0·001).

CONCLUSIONS

  The amenorrhoea group had severe endocrine and metabolic abnormalities, which appeared to be related to latent long-term complications and higher morbidity. The degree of dysbolism was positively associated with the change in BMI.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Center for Reproductive Medicine, Provincial Hospital affiliated to Shandong University, 324 Jingwu Road, Jinan, China.

    , , , ,

    Source

    Clinical endocrinology 76:3 2012 Mar pg 425-30

    MeSH

    Adult
    Amenorrhea
    Analysis of Variance
    Asian Continental Ancestry Group
    Blood Glucose
    Body Mass Index
    China
    Cholesterol
    Female
    Follicle Stimulating Hormone
    Hormones
    Humans
    Insulin
    Lipids
    Lipoproteins, HDL
    Lipoproteins, LDL
    Luteinizing Hormone
    Oligomenorrhea
    Polycystic Ovary Syndrome
    Prolactin
    Retrospective Studies
    Testosterone
    Triglycerides
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21815904

    Citation

    Xu, Xinghua, et al. "Endocrine and Metabolic Characteristics of Polycystic Ovary Syndrome in Chinese Women With Different Phenotypes." Clinical Endocrinology, vol. 76, no. 3, 2012, pp. 425-30.
    Xu X, Shi Y, Cui Y, et al. Endocrine and metabolic characteristics of polycystic ovary syndrome in Chinese women with different phenotypes. Clin Endocrinol (Oxf). 2012;76(3):425-30.
    Xu, X., Shi, Y., Cui, Y., Ma, J., Che, L., & Chen, Z. J. (2012). Endocrine and metabolic characteristics of polycystic ovary syndrome in Chinese women with different phenotypes. Clinical Endocrinology, 76(3), pp. 425-30. doi:10.1111/j.1365-2265.2011.04194.x.
    Xu X, et al. Endocrine and Metabolic Characteristics of Polycystic Ovary Syndrome in Chinese Women With Different Phenotypes. Clin Endocrinol (Oxf). 2012;76(3):425-30. PubMed PMID: 21815904.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Endocrine and metabolic characteristics of polycystic ovary syndrome in Chinese women with different phenotypes. AU - Xu,Xinghua, AU - Shi,Yuhua, AU - Cui,Yuqian, AU - Ma,Jinlong, AU - Che,Li, AU - Chen,Zi-Jiang, PY - 2011/8/6/entrez PY - 2011/8/6/pubmed PY - 2012/6/23/medline SP - 425 EP - 30 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 76 IS - 3 N2 - OBJECTIVE: The aim of this study was to describe the endocrine and metabolic characteristics of Chinese women with polycystic ovarian syndrome (PCOS) according to different phenotypes, including menstrual cycle pattern and body mass index (BMI). DESIGN: Retrospective study. PATIENT(S):   A total of 3539 patients with PCOS and 590 controls were recruited from the Centre for Reproductive Medicine. Patients with PCOS were divided into three groups according to the characteristics of the menstrual cycle (amenorrhoea, oligomenorrhea and eumenorrhea) and the BMI (<25 kg/m(2) ; 25 ≤ and ≤ 30 kg/m(2) ; and BMI > 30 kg/m(2) ). MEASUREMENTS: Waist circumference, hip circumference, weight, height, Ferriman-Gallwey score, and endocrine and metabolic variables were measured. RESULTS:   The serum testosterone, luteinizing hormone (LH) and oral glucose tolerance test 2 h-glucose levels were increased in the amenorrhoea group (P < 0·05). The triglycerides (TG) and low-density lipoprotein-cholesterol (LDL) levels were the highest in the amenorrhoea group (P < 0·05). The same trend existed in total cholesterol and non- high-density lipoprotein-cholesterol (HDL) levels, although there was no statistical significance (P > 0·05). Subjects with a BMI<25 kg/m(2) had higher values of follicle stimulating hormone (FSH), LH, LH/FSH and prolactin (P < 0·001) than the other two groups. The levels of TG, LDL and non-HDL and the indices of glucose and insulin metabolism increased with the change in BMI (P < 0·001). CONCLUSIONS:   The amenorrhoea group had severe endocrine and metabolic abnormalities, which appeared to be related to latent long-term complications and higher morbidity. The degree of dysbolism was positively associated with the change in BMI. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/21815904/Endocrine_and_metabolic_characteristics_of_polycystic_ovary_syndrome_in_Chinese_women_with_different_phenotypes_ L2 - https://doi.org/10.1111/j.1365-2265.2011.04194.x DB - PRIME DP - Unbound Medicine ER -