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Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes.
Cardiovasc Diabetol 2011; 10:72CD

Abstract

OBJECTIVE

We aimed to investigate whether elevated serum uric acid concentrations are associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in patients with type 2 diabetes.

METHODS

We conducted a population-based cross-sectional survey in Shanghai, with a total of 395 men and 631 women age 41 to 92 years. The carotid artery intima-media thickness (IMT) and carotid atherosclerotic plaques (PLQ) were measured by B-mode ultrasound. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.

RESULTS

Uric acid levels were negatively associated with duration of diabetes, fasting plasma glucose, glycohemoglobin, eGFR, HDL-cholesterol (all P < 0.001) and positively with BMI, CRP, waist circumference, triglycerides, systolic blood pressure, ACR, HOMA-IR and IMT (all P < 0.05). In the highest quartile of uric acid levels, the risks were substantially higher for MetS [odds ratio 3.97, (95% confidence interval 2.58-6.13)] (P < 0.001 for trend) and PLQ [odds ratio 2.71 (95% confidence interval 1.62-4.47)] (p = 0.013 for trend) compared with that in the lowest quartile of uric acid levels after multiple adjustment. These associations remained significant after further adjustment for potential confounders.

CONCLUSIONS

Serum uric acid level is associated with MetS and is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.

Authors+Show Affiliations

Institute of endocrinology and diabetology, Huashan hospital, Shanghai medical college, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21816063

Citation

Li, Qin, et al. "Serum Uric Acid Level and Its Association With Metabolic Syndrome and Carotid Atherosclerosis in Patients With Type 2 Diabetes." Cardiovascular Diabetology, vol. 10, 2011, p. 72.
Li Q, Yang Z, Lu B, et al. Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol. 2011;10:72.
Li, Q., Yang, Z., Lu, B., Wen, J., Ye, Z., Chen, L., ... Hu, R. (2011). Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. Cardiovascular Diabetology, 10, p. 72. doi:10.1186/1475-2840-10-72.
Li Q, et al. Serum Uric Acid Level and Its Association With Metabolic Syndrome and Carotid Atherosclerosis in Patients With Type 2 Diabetes. Cardiovasc Diabetol. 2011 Aug 4;10:72. PubMed PMID: 21816063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. AU - Li,Qin, AU - Yang,Zhen, AU - Lu,Bin, AU - Wen,Jie, AU - Ye,Zi, AU - Chen,Lili, AU - He,Min, AU - Tao,Xiaoming, AU - Zhang,Weiwei, AU - Huang,Ying, AU - Zhang,Zhaoyun, AU - Qu,Shen, AU - Hu,Renming, Y1 - 2011/08/04/ PY - 2011/07/23/received PY - 2011/08/04/accepted PY - 2011/8/6/entrez PY - 2011/8/6/pubmed PY - 2012/1/27/medline SP - 72 EP - 72 JF - Cardiovascular diabetology JO - Cardiovasc Diabetol VL - 10 N2 - OBJECTIVE: We aimed to investigate whether elevated serum uric acid concentrations are associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in patients with type 2 diabetes. METHODS: We conducted a population-based cross-sectional survey in Shanghai, with a total of 395 men and 631 women age 41 to 92 years. The carotid artery intima-media thickness (IMT) and carotid atherosclerotic plaques (PLQ) were measured by B-mode ultrasound. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. RESULTS: Uric acid levels were negatively associated with duration of diabetes, fasting plasma glucose, glycohemoglobin, eGFR, HDL-cholesterol (all P < 0.001) and positively with BMI, CRP, waist circumference, triglycerides, systolic blood pressure, ACR, HOMA-IR and IMT (all P < 0.05). In the highest quartile of uric acid levels, the risks were substantially higher for MetS [odds ratio 3.97, (95% confidence interval 2.58-6.13)] (P < 0.001 for trend) and PLQ [odds ratio 2.71 (95% confidence interval 1.62-4.47)] (p = 0.013 for trend) compared with that in the lowest quartile of uric acid levels after multiple adjustment. These associations remained significant after further adjustment for potential confounders. CONCLUSIONS: Serum uric acid level is associated with MetS and is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes. SN - 1475-2840 UR - https://www.unboundmedicine.com/medline/citation/21816063/Serum_uric_acid_level_and_its_association_with_metabolic_syndrome_and_carotid_atherosclerosis_in_patients_with_type_2_diabetes_ L2 - https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-10-72 DB - PRIME DP - Unbound Medicine ER -