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Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats.
Eur J Pharmacol. 2011 Oct 15; 668(3):492-6.EJ

Abstract

Fisetin (3, 7, 3', 4'-tetrahydroxyflavone) is a bioflavonoid found in fruits and vegetables. It exhibits a wide variety of pharmacological properties, including antioxidant, antiinflammatory and anticarcinogenic effects. Recently we have reported the hypoglycemic actions of fisetin. Oral administration of fisetin (10mg/kg body weight) to diabetic rats for 30 days established a significant (P<0.05) decline in blood glucose and glycosylated hemoglobin levels and a significant (P<0.05) increase in plasma insulin level. In the present study the activities of key enzymes of carbohydrate metabolism were assayed to establish the modulatory actions of fisetin in maintaining the glucose homeostasis. The altered activities of key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase in liver and kidney tissues of diabetic rats were significantly (P<0.05) reverted to near normalcy by the administration of fisetin. Thus, fisetin regulates carbohydrate metabolism by modulating the key regulatory enzymes in the hepatic and renal tissues of diabetic rats.

Authors+Show Affiliations

Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21816145

Citation

Prasath, Gopalan Sriram, and Sorimuthu Pillai Subramanian. "Modulatory Effects of Fisetin, a Bioflavonoid, On Hyperglycemia By Attenuating the Key Enzymes of Carbohydrate Metabolism in Hepatic and Renal Tissues in Streptozotocin-induced Diabetic Rats." European Journal of Pharmacology, vol. 668, no. 3, 2011, pp. 492-6.
Prasath GS, Subramanian SP. Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2011;668(3):492-6.
Prasath, G. S., & Subramanian, S. P. (2011). Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats. European Journal of Pharmacology, 668(3), 492-6. https://doi.org/10.1016/j.ejphar.2011.07.021
Prasath GS, Subramanian SP. Modulatory Effects of Fisetin, a Bioflavonoid, On Hyperglycemia By Attenuating the Key Enzymes of Carbohydrate Metabolism in Hepatic and Renal Tissues in Streptozotocin-induced Diabetic Rats. Eur J Pharmacol. 2011 Oct 15;668(3):492-6. PubMed PMID: 21816145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats. AU - Prasath,Gopalan Sriram, AU - Subramanian,Sorimuthu Pillai, Y1 - 2011/07/29/ PY - 2011/03/09/received PY - 2011/06/23/revised PY - 2011/07/07/accepted PY - 2011/8/6/entrez PY - 2011/8/6/pubmed PY - 2012/1/20/medline SP - 492 EP - 6 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 668 IS - 3 N2 - Fisetin (3, 7, 3', 4'-tetrahydroxyflavone) is a bioflavonoid found in fruits and vegetables. It exhibits a wide variety of pharmacological properties, including antioxidant, antiinflammatory and anticarcinogenic effects. Recently we have reported the hypoglycemic actions of fisetin. Oral administration of fisetin (10mg/kg body weight) to diabetic rats for 30 days established a significant (P<0.05) decline in blood glucose and glycosylated hemoglobin levels and a significant (P<0.05) increase in plasma insulin level. In the present study the activities of key enzymes of carbohydrate metabolism were assayed to establish the modulatory actions of fisetin in maintaining the glucose homeostasis. The altered activities of key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase in liver and kidney tissues of diabetic rats were significantly (P<0.05) reverted to near normalcy by the administration of fisetin. Thus, fisetin regulates carbohydrate metabolism by modulating the key regulatory enzymes in the hepatic and renal tissues of diabetic rats. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/21816145/Modulatory_effects_of_fisetin_a_bioflavonoid_on_hyperglycemia_by_attenuating_the_key_enzymes_of_carbohydrate_metabolism_in_hepatic_and_renal_tissues_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)00796-5 DB - PRIME DP - Unbound Medicine ER -