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Lipoprotein lipase Ser447Ter polymorphism associated with the risk of ischemic stroke: a meta-analysis.
Thromb Res. 2011 Nov; 128(5):e107-12.TR

Abstract

INTRODUCTION

Previous studies suggested lipoprotein lipase (LPL) Ser447Ter and Asn291Ser polymorphisms were associated with the risk of ischemic heart disease, however, their effects on ischemic stroke were controversial. A meta-analysis was performed to assess the associations between these two LPL polymorphisms and the risk of ischemic stroke.

METHODS

The electronic databases PubMed and Embase were used to identify relevant studies by two interviews independently. The pooled odds ratios (ORs) and weighted mean differences (WMD) with 95% confidence interval (CI) were estimated for the risk of ischemic stroke and the plasma lipids in various Ser447Ter genotypes respectively. A fixed or random effect model was selected for pooling data based on homogeneity test.

RESULTS

13 studies including 4,681 ischemic stroke cases and 8,516 controls were involved in this meta-analysis. Overall, LPL Ter447 variant was associated with a significantly reduced risk for ischemic stroke (OR=0.79, 95% CI: 0.68-0.93) both in Caucasian (OR=0.87, 95% CI: 0.77-0.97) and East-Asian (OR=0.65, 95% CI: 0.43-0.99), whereas no significant association of Ser291 variant was observed (OR=1.25, 95% CI: 0.96-1.63). The Ser447Ter polymorphism may be more important in association with the decreased risk of atherosclerotic stroke (OR=0.44, 95% CI: 0.32-0.62) which derived from significantly increased high density lipoprotein cholesterol, decreased triglyceride and total cholesterol in Ter447 carriers compared with non-carriers.

CONCLUSIONS

This meta-analysis indicated that LPL Ser447Ter polymorphism was associated with a significant reduction in the risk of ischemic stroke, especially atherosclerotic stroke subtype in both Caucasian and East-Asian.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing 210029, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21816453

Citation

Wang, Chun, et al. "Lipoprotein Lipase Ser447Ter Polymorphism Associated With the Risk of Ischemic Stroke: a Meta-analysis." Thrombosis Research, vol. 128, no. 5, 2011, pp. e107-12.
Wang C, Sun T, Li H, et al. Lipoprotein lipase Ser447Ter polymorphism associated with the risk of ischemic stroke: a meta-analysis. Thromb Res. 2011;128(5):e107-12.
Wang, C., Sun, T., Li, H., Bai, J., & Li, Y. (2011). Lipoprotein lipase Ser447Ter polymorphism associated with the risk of ischemic stroke: a meta-analysis. Thrombosis Research, 128(5), e107-12. https://doi.org/10.1016/j.thromres.2011.07.016
Wang C, et al. Lipoprotein Lipase Ser447Ter Polymorphism Associated With the Risk of Ischemic Stroke: a Meta-analysis. Thromb Res. 2011;128(5):e107-12. PubMed PMID: 21816453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoprotein lipase Ser447Ter polymorphism associated with the risk of ischemic stroke: a meta-analysis. AU - Wang,Chun, AU - Sun,Tao, AU - Li,Huiqiao, AU - Bai,Jianling, AU - Li,Ying, Y1 - 2011/08/03/ PY - 2011/03/18/received PY - 2011/06/28/revised PY - 2011/07/11/accepted PY - 2011/8/6/entrez PY - 2011/8/6/pubmed PY - 2012/3/23/medline SP - e107 EP - 12 JF - Thrombosis research JO - Thromb Res VL - 128 IS - 5 N2 - INTRODUCTION: Previous studies suggested lipoprotein lipase (LPL) Ser447Ter and Asn291Ser polymorphisms were associated with the risk of ischemic heart disease, however, their effects on ischemic stroke were controversial. A meta-analysis was performed to assess the associations between these two LPL polymorphisms and the risk of ischemic stroke. METHODS: The electronic databases PubMed and Embase were used to identify relevant studies by two interviews independently. The pooled odds ratios (ORs) and weighted mean differences (WMD) with 95% confidence interval (CI) were estimated for the risk of ischemic stroke and the plasma lipids in various Ser447Ter genotypes respectively. A fixed or random effect model was selected for pooling data based on homogeneity test. RESULTS: 13 studies including 4,681 ischemic stroke cases and 8,516 controls were involved in this meta-analysis. Overall, LPL Ter447 variant was associated with a significantly reduced risk for ischemic stroke (OR=0.79, 95% CI: 0.68-0.93) both in Caucasian (OR=0.87, 95% CI: 0.77-0.97) and East-Asian (OR=0.65, 95% CI: 0.43-0.99), whereas no significant association of Ser291 variant was observed (OR=1.25, 95% CI: 0.96-1.63). The Ser447Ter polymorphism may be more important in association with the decreased risk of atherosclerotic stroke (OR=0.44, 95% CI: 0.32-0.62) which derived from significantly increased high density lipoprotein cholesterol, decreased triglyceride and total cholesterol in Ter447 carriers compared with non-carriers. CONCLUSIONS: This meta-analysis indicated that LPL Ser447Ter polymorphism was associated with a significant reduction in the risk of ischemic stroke, especially atherosclerotic stroke subtype in both Caucasian and East-Asian. SN - 1879-2472 UR - https://www.unboundmedicine.com/medline/citation/21816453/Lipoprotein_lipase_Ser447Ter_polymorphism_associated_with_the_risk_of_ischemic_stroke:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(11)00362-8 DB - PRIME DP - Unbound Medicine ER -