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Anthropometric factors, physical activity, and risk of non-Hodgkin's lymphoma in the Women's Health Initiative.

Abstract

BACKGROUND

Incidence rates of non-Hodgkin's lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20th century, but little is known about its etiology. Obesity is associated with impaired immune function through which it may influence the risk of NHL; other factors reflecting energy homeostasis (height, abdominal adiposity, and physical activity) may also be involved.

METHODS

We examined the association of anthropometric factors and physical activity with risk of NHL and its major subtypes in a large cohort of women aged 50-79 years old who were enrolled at 40 clinical centers in the United States between 1993 and 1998. Over a mean follow-up period of 11 years, 1123 cases of NHL were identified among 158,975 women. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI).

RESULTS

Height at baseline was positively associated with risk of all NHL and with that of diffuse large B-cell lymphoma (HRs(q4vs.q1) 1.19, 95% CI 1.00-1.43 and 1.43, 95% CI 1.01-2.03, respectively). Measures of obesity and abdominal adiposity at baseline were not associated with risk. Hazard ratios for NHL were increased for women in the highest quartile of weight and body mass index at age 18 (HRs(q4vs.q1) 1.29, 95% CI 1.01-1.65 and 1.27, 95% CI 1.01-1.59, respectively). Some measures of recreational physical activity were modestly associated with increased risk of NHL overall, but there were no clear associations with specific subtypes.

CONCLUSION

Our findings regarding anthropometric measures are consistent with those of several previous reports, suggesting that early life influences on growth and immune function may influence the risk of NHL later in life.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Geoffrey.Kabat@einstein.yu.edu

    , , , , , ,

    Source

    Cancer epidemiology 36:1 2012 Feb pg 52-9

    MeSH

    Aged
    Anthropometry
    Body Mass Index
    Female
    Humans
    Lymphoma, Non-Hodgkin
    Middle Aged
    Motor Activity
    Obesity
    Risk Factors
    United States
    Women's Health

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    21816698

    Citation

    Kabat, Geoffrey C., et al. "Anthropometric Factors, Physical Activity, and Risk of non-Hodgkin's Lymphoma in the Women's Health Initiative." Cancer Epidemiology, vol. 36, no. 1, 2012, pp. 52-9.
    Kabat GC, Kim MY, Jean-Wactawski-Wende , et al. Anthropometric factors, physical activity, and risk of non-Hodgkin's lymphoma in the Women's Health Initiative. Cancer Epidemiol. 2012;36(1):52-9.
    Kabat, G. C., Kim, M. Y., Jean-Wactawski-Wende, ., Bea, J. W., Edlefsen, K. L., Adams-Campbell, L. L., ... Rohan, T. E. (2012). Anthropometric factors, physical activity, and risk of non-Hodgkin's lymphoma in the Women's Health Initiative. Cancer Epidemiology, 36(1), pp. 52-9. doi:10.1016/j.canep.2011.05.014.
    Kabat GC, et al. Anthropometric Factors, Physical Activity, and Risk of non-Hodgkin's Lymphoma in the Women's Health Initiative. Cancer Epidemiol. 2012;36(1):52-9. PubMed PMID: 21816698.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anthropometric factors, physical activity, and risk of non-Hodgkin's lymphoma in the Women's Health Initiative. AU - Kabat,Geoffrey C, AU - Kim,Mimi Y, AU - Jean-Wactawski-Wende,, AU - Bea,Jennifer W, AU - Edlefsen,Kerstin L, AU - Adams-Campbell,Lucile L, AU - De Roos,Anneclaire J, AU - Rohan,Thomas E, Y1 - 2011/08/04/ PY - 2011/01/28/received PY - 2011/05/24/revised PY - 2011/05/24/accepted PY - 2011/8/6/entrez PY - 2011/8/6/pubmed PY - 2012/7/4/medline SP - 52 EP - 9 JF - Cancer epidemiology JO - Cancer Epidemiol VL - 36 IS - 1 N2 - BACKGROUND: Incidence rates of non-Hodgkin's lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20th century, but little is known about its etiology. Obesity is associated with impaired immune function through which it may influence the risk of NHL; other factors reflecting energy homeostasis (height, abdominal adiposity, and physical activity) may also be involved. METHODS: We examined the association of anthropometric factors and physical activity with risk of NHL and its major subtypes in a large cohort of women aged 50-79 years old who were enrolled at 40 clinical centers in the United States between 1993 and 1998. Over a mean follow-up period of 11 years, 1123 cases of NHL were identified among 158,975 women. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). RESULTS: Height at baseline was positively associated with risk of all NHL and with that of diffuse large B-cell lymphoma (HRs(q4vs.q1) 1.19, 95% CI 1.00-1.43 and 1.43, 95% CI 1.01-2.03, respectively). Measures of obesity and abdominal adiposity at baseline were not associated with risk. Hazard ratios for NHL were increased for women in the highest quartile of weight and body mass index at age 18 (HRs(q4vs.q1) 1.29, 95% CI 1.01-1.65 and 1.27, 95% CI 1.01-1.59, respectively). Some measures of recreational physical activity were modestly associated with increased risk of NHL overall, but there were no clear associations with specific subtypes. CONCLUSION: Our findings regarding anthropometric measures are consistent with those of several previous reports, suggesting that early life influences on growth and immune function may influence the risk of NHL later in life. SN - 1877-783X UR - https://www.unboundmedicine.com/medline/citation/21816698/Anthropometric_factors_physical_activity_and_risk_of_non_Hodgkin's_lymphoma_in_the_Women's_Health_Initiative_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1877-7821(11)00096-8 DB - PRIME DP - Unbound Medicine ER -