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Wernicke's encephalopathy.
Am Fam Physician. 1990 Apr; 41(4):1205-9.AF

Abstract

Wernicke's encephalopathy should be considered as a possible diagnosis in comatose and hypothermic patients. The classic triad of confusion, ophthalmoplegia (or nystagmus) and ataxia may be absent, and the history of alcohol abuse or other causes of thiamine deficiency may be unknown. Left untreated, acute Wernicke's encephalopathy has a 17 percent mortality rate. Since the morbidity from Wernicke's encephalopathy is potentially reversible with parenteral thiamine, and large doses of thiamine can be given without documented ill effects, it is recommended that all comatose or hypothermic patients, as well as those with more classic presentations of Wernicke's encephalopathy, be given parenteral thiamine before administration of glucose.

Authors+Show Affiliations

University of Alabama School of Medicine, Tuscaloosa.No affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

2181837

Citation

Lindberg, M C., and R A. Oyler. "Wernicke's Encephalopathy." American Family Physician, vol. 41, no. 4, 1990, pp. 1205-9.
Lindberg MC, Oyler RA. Wernicke's encephalopathy. Am Fam Physician. 1990;41(4):1205-9.
Lindberg, M. C., & Oyler, R. A. (1990). Wernicke's encephalopathy. American Family Physician, 41(4), 1205-9.
Lindberg MC, Oyler RA. Wernicke's Encephalopathy. Am Fam Physician. 1990;41(4):1205-9. PubMed PMID: 2181837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wernicke's encephalopathy. AU - Lindberg,M C, AU - Oyler,R A, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 1205 EP - 9 JF - American family physician JO - Am Fam Physician VL - 41 IS - 4 N2 - Wernicke's encephalopathy should be considered as a possible diagnosis in comatose and hypothermic patients. The classic triad of confusion, ophthalmoplegia (or nystagmus) and ataxia may be absent, and the history of alcohol abuse or other causes of thiamine deficiency may be unknown. Left untreated, acute Wernicke's encephalopathy has a 17 percent mortality rate. Since the morbidity from Wernicke's encephalopathy is potentially reversible with parenteral thiamine, and large doses of thiamine can be given without documented ill effects, it is recommended that all comatose or hypothermic patients, as well as those with more classic presentations of Wernicke's encephalopathy, be given parenteral thiamine before administration of glucose. SN - 0002-838X UR - https://www.unboundmedicine.com/medline/citation/2181837/Wernicke's_encephalopathy_ DB - PRIME DP - Unbound Medicine ER -