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[Effect of Panax notoginseng saponins on APP gene transcription in the brain tissue of SAMP8].
Zhong Yao Cai. 2011 Jan; 34(1):77-80.ZY

Abstract

OBJECTIVE

To study the effect of Panax notoginseng saponins (PNS) on learning and memory ability and APP gene transcription in the brain tissue in senescence accelerated mouse prone 8 (SAMP8).

METHODS

SAMP8 were randomly divided into high-does PNS group, low-does PNS group, huperzin A group and model group,the treatment groups were treated with the designed drugs respectively by intragastric administration for 4 consecutive weeks. The same volume of double distilled water was given to model group. After treatment, the abilities of learning and memory of the mice were tested with morris water maze, the mRNA content of APP was assayed by reverse transcription (RT) and real-time polymerase chain reaction (RT-PCR).

RESULTS

PNS could improve the abilities of learning and memory, high-does PNS could reduce the mRNA content of APP in the brain tissue of SAMP8.

CONCLUSION

PNS can improve the abilities of learning and memory of SAMP8, the mechanism may be relevant to down-regulating the expression of APP gene at transcriptional level.

Authors+Show Affiliations

Zhong ZG
Center of Research & Development of New Drugs, Guangxi Traditional Chinese Medical University, Nanning 530001, China. zhongzg@gxtcmu.edu.cn
Lv L
No affiliation info available
Chai LM
No affiliation info available
Wu DP
No affiliation info available
Zhang WY
No affiliation info available
Huang JL
No affiliation info available
Gang YW
No affiliation info available
Li F
No affiliation info available
Zu B
No affiliation info available

MeSH

Administration, OralAgingAmyloid beta-Protein PrecursorAnimalsBrainDown-RegulationDrugs, Chinese HerbalGene Expression RegulationMaze LearningMemoryMiceMice, Inbred StrainsPanax notoginsengRNA, MessengerRandom AllocationReal-Time Polymerase Chain ReactionSaponins

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21818973

Citation

Zhong, Zhen-guo, et al. "[Effect of Panax Notoginseng Saponins On APP Gene Transcription in the Brain Tissue of SAMP8]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 34, no. 1, 2011, pp. 77-80.
Zhong ZG, Lv L, Chai LM, et al. [Effect of Panax notoginseng saponins on APP gene transcription in the brain tissue of SAMP8]. Zhong Yao Cai. 2011;34(1):77-80.
Zhong, Z. G., Lv, L., Chai, L. M., Wu, D. P., Zhang, W. Y., Huang, J. L., Gang, Y. W., Li, F., & Zu, B. (2011). [Effect of Panax notoginseng saponins on APP gene transcription in the brain tissue of SAMP8]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 34(1), 77-80.
Zhong ZG, et al. [Effect of Panax Notoginseng Saponins On APP Gene Transcription in the Brain Tissue of SAMP8]. Zhong Yao Cai. 2011;34(1):77-80. PubMed PMID: 21818973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of Panax notoginseng saponins on APP gene transcription in the brain tissue of SAMP8]. AU - Zhong,Zhen-guo, AU - Lv,Liang, AU - Chai,Li-min, AU - Wu,Deng-pan, AU - Zhang,Wen-yan, AU - Huang,Jin-lan, AU - Gang,Yi-wen, AU - Li,Fei, AU - Zu,Bo, PY - 2011/8/9/entrez PY - 2011/8/9/pubmed PY - 2012/1/6/medline SP - 77 EP - 80 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 34 IS - 1 N2 - OBJECTIVE: To study the effect of Panax notoginseng saponins (PNS) on learning and memory ability and APP gene transcription in the brain tissue in senescence accelerated mouse prone 8 (SAMP8). METHODS: SAMP8 were randomly divided into high-does PNS group, low-does PNS group, huperzin A group and model group,the treatment groups were treated with the designed drugs respectively by intragastric administration for 4 consecutive weeks. The same volume of double distilled water was given to model group. After treatment, the abilities of learning and memory of the mice were tested with morris water maze, the mRNA content of APP was assayed by reverse transcription (RT) and real-time polymerase chain reaction (RT-PCR). RESULTS: PNS could improve the abilities of learning and memory, high-does PNS could reduce the mRNA content of APP in the brain tissue of SAMP8. CONCLUSION: PNS can improve the abilities of learning and memory of SAMP8, the mechanism may be relevant to down-regulating the expression of APP gene at transcriptional level. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/21818973/[Effect_of_Panax_notoginseng_saponins_on_APP_gene_transcription_in_the_brain_tissue_of_SAMP8]_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -