Tags

Type your tag names separated by a space and hit enter

A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum.

Abstract

While longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive gray matter reduction of the superior temporal gyrus (STG) during the early phases of schizophrenia, it remains largely unknown whether other temporal lobe structures also exhibit similar progressive changes and whether these changes, if present, are specific to schizophrenia among the spectrum disorders. In this longitudinal MRI study, the gray matter volumes of the fusiform, middle temporal, and inferior temporal gyri were measured at baseline and follow-up scans (mean inter-scan interval=2.7 years) in 18 patients with first-episode schizophrenia, 13 patients with schizotypal disorder, and 20 healthy controls. Both schizophrenia and schizotypal patients had a smaller fusiform gyrus than controls bilaterally at both time points, whereas no group difference was found in the middle and inferior temporal gyri. In the longitudinal comparison, the schizophrenia patients showed significant fusiform gyrus reduction (left, -2.6%/year; right, -2.3%/year) compared with schizotypal patients (left: -0.4%/year; right: -0.2%/year) and controls (left: 0.1%/year; right: 0.0%/year). However, the middle and inferior temporal gyri did not exhibit significant progressive gray matter change in all diagnostic groups. In the schizophrenia patients, a higher cumulative dose of antipsychotics during follow-up was significantly correlated with less severe gray matter reduction in the left fusiform gyrus. The annual gray matter loss of the fusiform gyrus did not correlate with that of the STG previously reported in the same subjects. Our findings suggest regional specificity of the progressive gray matter reduction in the temporal lobe structures, which might be specific to overt schizophrenia within the schizophrenia spectrum.

Authors+Show Affiliations

Department of Neuropsychiatry, University of Toyama, Toyama, Japan. tsutomu@med.u-toyama.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21820482

Citation

Takahashi, Tsutomu, et al. "A Follow-up MRI Study of the Fusiform Gyrus and Middle and Inferior Temporal Gyri in Schizophrenia Spectrum." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 35, no. 8, 2011, pp. 1957-64.
Takahashi T, Zhou SY, Nakamura K, et al. A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(8):1957-64.
Takahashi, T., Zhou, S. Y., Nakamura, K., Tanino, R., Furuichi, A., Kido, M., ... Suzuki, M. (2011). A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum. Progress in Neuro-psychopharmacology & Biological Psychiatry, 35(8), pp. 1957-64. doi:10.1016/j.pnpbp.2011.07.009.
Takahashi T, et al. A Follow-up MRI Study of the Fusiform Gyrus and Middle and Inferior Temporal Gyri in Schizophrenia Spectrum. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Dec 1;35(8):1957-64. PubMed PMID: 21820482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum. AU - Takahashi,Tsutomu, AU - Zhou,Shi-Yu, AU - Nakamura,Kazue, AU - Tanino,Ryoichiro, AU - Furuichi,Atsushi, AU - Kido,Mikio, AU - Kawasaki,Yasuhiro, AU - Noguchi,Kyo, AU - Seto,Hikaru, AU - Kurachi,Masayoshi, AU - Suzuki,Michio, Y1 - 2011/07/27/ PY - 2011/05/26/received PY - 2011/06/16/revised PY - 2011/07/19/accepted PY - 2011/8/9/entrez PY - 2011/8/9/pubmed PY - 2014/6/10/medline SP - 1957 EP - 64 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 35 IS - 8 N2 - While longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive gray matter reduction of the superior temporal gyrus (STG) during the early phases of schizophrenia, it remains largely unknown whether other temporal lobe structures also exhibit similar progressive changes and whether these changes, if present, are specific to schizophrenia among the spectrum disorders. In this longitudinal MRI study, the gray matter volumes of the fusiform, middle temporal, and inferior temporal gyri were measured at baseline and follow-up scans (mean inter-scan interval=2.7 years) in 18 patients with first-episode schizophrenia, 13 patients with schizotypal disorder, and 20 healthy controls. Both schizophrenia and schizotypal patients had a smaller fusiform gyrus than controls bilaterally at both time points, whereas no group difference was found in the middle and inferior temporal gyri. In the longitudinal comparison, the schizophrenia patients showed significant fusiform gyrus reduction (left, -2.6%/year; right, -2.3%/year) compared with schizotypal patients (left: -0.4%/year; right: -0.2%/year) and controls (left: 0.1%/year; right: 0.0%/year). However, the middle and inferior temporal gyri did not exhibit significant progressive gray matter change in all diagnostic groups. In the schizophrenia patients, a higher cumulative dose of antipsychotics during follow-up was significantly correlated with less severe gray matter reduction in the left fusiform gyrus. The annual gray matter loss of the fusiform gyrus did not correlate with that of the STG previously reported in the same subjects. Our findings suggest regional specificity of the progressive gray matter reduction in the temporal lobe structures, which might be specific to overt schizophrenia within the schizophrenia spectrum. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/21820482/A_follow_up_MRI_study_of_the_fusiform_gyrus_and_middle_and_inferior_temporal_gyri_in_schizophrenia_spectrum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(11)00227-2 DB - PRIME DP - Unbound Medicine ER -