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Musculoskeletal techniques for clinically stable adults with cystic fibrosis: a preliminary randomised controlled trial.
Physiotherapy. 2011 Sep; 97(3):209-17.P

Abstract

AIMS

To assess the sensitivity of selected outcome measures to any change resulting from treatment of adults with cystic fibrosis with physiotherapy musculoskeletal techniques, use the data for sample size calculations for future studies and assess the acceptability of the methods to potential participants.

DESIGN

Preliminary, prospective, single-blind, randomised controlled trial.

SETTING

Specialist cystic fibrosis centre.

PARTICIPANTS

Adults recruited from a cystic fibrosis outpatient clinic.

INTERVENTIONS

The control group received normal optimal physiotherapy care and the intervention group received weekly musculoskeletal treatment for 6 weeks in addition to normal optimal physiotherapy care.

OUTCOME MEASURES

Recorded at baseline, 3, 6 and 12 weeks. The outcome measures were posture (thoracic index), chest wall excursion, forced expiratory volume in 1 second (FEV₁), visual analogue scale for pain, modified shuttle test and Cystic Fibrosis Quality of Life Questionnaire--Section One (physical functioning).

STATISTICAL ANALYSIS

Descriptive statistics [using medians and interquartile ranges (IQRs)] and linear regression mixed model.

RESULTS

From a total of 20 subjects, 10 were randomised to each group. Fifty percent of subjects were male, with a median age of 27 years (IQR 25 to 34), median FEV(1) of 1.75 l (IQR 1.4 to 2.4) and median body mass index of 20.8 (IQR 20.0 to 23.5). Baseline differences between groups in thoracic index and modified shuttle test made any differences difficult to interpret, but the results for thoracic index and chest wall excursion at the third rib in the treatment group showed a trend towards improvement. The usefulness of FEV₁, the visual analogue scale for pain and the Cystic Fibrosis Quality of Life Questionnaire as measures is unclear.

CONCLUSION

Further musculoskeletal studies in people with cystic fibrosis should consider using thoracic index and a measure of lung function in addition to FEV₁. The musculoskeletal techniques appear to be acceptable to people with cystic fibrosis, and do not seem to have associated adverse effects.

Authors+Show Affiliations

Department of Cystic Fibrosis, Royal Brompton & Harefield NHS Foundation Trust, Sydney Street, London SW36NP, UK. catherine.sandsund@rmh.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21820539

Citation

Sandsund, Catherine A., et al. "Musculoskeletal Techniques for Clinically Stable Adults With Cystic Fibrosis: a Preliminary Randomised Controlled Trial." Physiotherapy, vol. 97, no. 3, 2011, pp. 209-17.
Sandsund CA, Roughton M, Hodson ME, et al. Musculoskeletal techniques for clinically stable adults with cystic fibrosis: a preliminary randomised controlled trial. Physiotherapy. 2011;97(3):209-17.
Sandsund, C. A., Roughton, M., Hodson, M. E., & Pryor, J. A. (2011). Musculoskeletal techniques for clinically stable adults with cystic fibrosis: a preliminary randomised controlled trial. Physiotherapy, 97(3), 209-17. https://doi.org/10.1016/j.physio.2010.08.016
Sandsund CA, et al. Musculoskeletal Techniques for Clinically Stable Adults With Cystic Fibrosis: a Preliminary Randomised Controlled Trial. Physiotherapy. 2011;97(3):209-17. PubMed PMID: 21820539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Musculoskeletal techniques for clinically stable adults with cystic fibrosis: a preliminary randomised controlled trial. AU - Sandsund,Catherine A, AU - Roughton,Michael, AU - Hodson,Margaret E, AU - Pryor,Jennifer A, Y1 - 2010/12/13/ PY - 2009/08/28/received PY - 2010/08/04/accepted PY - 2011/8/9/entrez PY - 2011/8/9/pubmed PY - 2011/12/14/medline SP - 209 EP - 17 JF - Physiotherapy JO - Physiotherapy VL - 97 IS - 3 N2 - AIMS: To assess the sensitivity of selected outcome measures to any change resulting from treatment of adults with cystic fibrosis with physiotherapy musculoskeletal techniques, use the data for sample size calculations for future studies and assess the acceptability of the methods to potential participants. DESIGN: Preliminary, prospective, single-blind, randomised controlled trial. SETTING: Specialist cystic fibrosis centre. PARTICIPANTS: Adults recruited from a cystic fibrosis outpatient clinic. INTERVENTIONS: The control group received normal optimal physiotherapy care and the intervention group received weekly musculoskeletal treatment for 6 weeks in addition to normal optimal physiotherapy care. OUTCOME MEASURES: Recorded at baseline, 3, 6 and 12 weeks. The outcome measures were posture (thoracic index), chest wall excursion, forced expiratory volume in 1 second (FEV₁), visual analogue scale for pain, modified shuttle test and Cystic Fibrosis Quality of Life Questionnaire--Section One (physical functioning). STATISTICAL ANALYSIS: Descriptive statistics [using medians and interquartile ranges (IQRs)] and linear regression mixed model. RESULTS: From a total of 20 subjects, 10 were randomised to each group. Fifty percent of subjects were male, with a median age of 27 years (IQR 25 to 34), median FEV(1) of 1.75 l (IQR 1.4 to 2.4) and median body mass index of 20.8 (IQR 20.0 to 23.5). Baseline differences between groups in thoracic index and modified shuttle test made any differences difficult to interpret, but the results for thoracic index and chest wall excursion at the third rib in the treatment group showed a trend towards improvement. The usefulness of FEV₁, the visual analogue scale for pain and the Cystic Fibrosis Quality of Life Questionnaire as measures is unclear. CONCLUSION: Further musculoskeletal studies in people with cystic fibrosis should consider using thoracic index and a measure of lung function in addition to FEV₁. The musculoskeletal techniques appear to be acceptable to people with cystic fibrosis, and do not seem to have associated adverse effects. SN - 1873-1465 UR - https://www.unboundmedicine.com/medline/citation/21820539/Musculoskeletal_techniques_for_clinically_stable_adults_with_cystic_fibrosis:_a_preliminary_randomised_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9406(10)00114-8 DB - PRIME DP - Unbound Medicine ER -