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Relationship between circulating adipokines and insulin resistance during pregnancy and postpartum in women with gestational diabetes.
Arch Med Res. 2011 May; 42(4):318-23.AM

Abstract

BACKGROUND AND AIMS

We undertook this study to assess the relationship between circulating adipokines and insulin resistance during pregnancy and postpartum in women with gestational diabetes mellitus (GDM).

METHODS

This was a prospective study including 60 women with GDM and 60 subjects with normal gestation who were evaluated at gestational week 30, 6 weeks and 6 months postpartum. Circulating adipokines that were evaluated during the study were leptin, adiponectin, retinol-binding protein-4 (RBP4), and tumor necrosis factor-alpha (TNF-α).

RESULTS

Women with GDM showed higher insulin resistance measured by HOMA-IR than subjects with normal gestation (2.3 ± 2.3 vs. 1.3 ± 0.95). There was no difference between groups in adipokines; however, in women with a healthy pregnancy, RBP4 was associated with insulin resistance (r = 0.47, p <0.05). At 6 weeks and 6 months postpartum, women with previous GDM exhibited persistent elevated leptin and insulin resistance. RBP4 was associated with insulin resistance only in women with a previous healthy pregnancy (r = 0.51, p <0.05). In addition, progressively impaired glucose tolerance was observed after delivery in women with previous GDM.

CONCLUSIONS

It was demonstrated that GDM is associated with greater insulin resistance than observed in normal pregnancy; however, adipokines are similar in both groups. RBP4 levels are significantly associated with insulin resistance in healthy women during pregnancy and postpartum. After a pregnancy complicated by GDM, leptin and insulin resistance remain elevated and glucose tolerance worsens.

Authors+Show Affiliations

Endocrine Research Unit, National Medical Center, Mexican Social Security Institute, Mexico City, Mexico. sgrenata@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21820611

Citation

Saucedo, Renata, et al. "Relationship Between Circulating Adipokines and Insulin Resistance During Pregnancy and Postpartum in Women With Gestational Diabetes." Archives of Medical Research, vol. 42, no. 4, 2011, pp. 318-23.
Saucedo R, Zarate A, Basurto L, et al. Relationship between circulating adipokines and insulin resistance during pregnancy and postpartum in women with gestational diabetes. Arch Med Res. 2011;42(4):318-23.
Saucedo, R., Zarate, A., Basurto, L., Hernandez, M., Puello, E., Galvan, R., & Campos, S. (2011). Relationship between circulating adipokines and insulin resistance during pregnancy and postpartum in women with gestational diabetes. Archives of Medical Research, 42(4), 318-23. https://doi.org/10.1016/j.arcmed.2011.06.009
Saucedo R, et al. Relationship Between Circulating Adipokines and Insulin Resistance During Pregnancy and Postpartum in Women With Gestational Diabetes. Arch Med Res. 2011;42(4):318-23. PubMed PMID: 21820611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between circulating adipokines and insulin resistance during pregnancy and postpartum in women with gestational diabetes. AU - Saucedo,Renata, AU - Zarate,Arturo, AU - Basurto,Lourdes, AU - Hernandez,Marcelino, AU - Puello,Edgardo, AU - Galvan,Rosa, AU - Campos,Sandra, PY - 2011/03/23/received PY - 2011/06/14/accepted PY - 2011/8/9/entrez PY - 2011/8/9/pubmed PY - 2011/12/13/medline SP - 318 EP - 23 JF - Archives of medical research JO - Arch. Med. Res. VL - 42 IS - 4 N2 - BACKGROUND AND AIMS: We undertook this study to assess the relationship between circulating adipokines and insulin resistance during pregnancy and postpartum in women with gestational diabetes mellitus (GDM). METHODS: This was a prospective study including 60 women with GDM and 60 subjects with normal gestation who were evaluated at gestational week 30, 6 weeks and 6 months postpartum. Circulating adipokines that were evaluated during the study were leptin, adiponectin, retinol-binding protein-4 (RBP4), and tumor necrosis factor-alpha (TNF-α). RESULTS: Women with GDM showed higher insulin resistance measured by HOMA-IR than subjects with normal gestation (2.3 ± 2.3 vs. 1.3 ± 0.95). There was no difference between groups in adipokines; however, in women with a healthy pregnancy, RBP4 was associated with insulin resistance (r = 0.47, p <0.05). At 6 weeks and 6 months postpartum, women with previous GDM exhibited persistent elevated leptin and insulin resistance. RBP4 was associated with insulin resistance only in women with a previous healthy pregnancy (r = 0.51, p <0.05). In addition, progressively impaired glucose tolerance was observed after delivery in women with previous GDM. CONCLUSIONS: It was demonstrated that GDM is associated with greater insulin resistance than observed in normal pregnancy; however, adipokines are similar in both groups. RBP4 levels are significantly associated with insulin resistance in healthy women during pregnancy and postpartum. After a pregnancy complicated by GDM, leptin and insulin resistance remain elevated and glucose tolerance worsens. SN - 1873-5487 UR - https://www.unboundmedicine.com/medline/citation/21820611/Relationship_between_circulating_adipokines_and_insulin_resistance_during_pregnancy_and_postpartum_in_women_with_gestational_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(11)00131-7 DB - PRIME DP - Unbound Medicine ER -