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House dust mite sensitization in toddlers predicts current wheeze at age 12 years.
J Allergy Clin Immunol. 2011 Oct; 128(4):782-788.e9.JA

Abstract

BACKGROUND

Identification of children at risk of developing asthma provides a window of opportunity for risk-reducing interventions. Allergen sensitization might identify high-risk children.

OBJECTIVE

We sought to determine whether skin prick tests (SPTs) to individual allergens up to age 2 years predict wheeze at age 12 years.

METHODS

In a birth cohort of 620 children oversampled for familial allergy, sensitization was assessed by using SPTs (monosensitized, polysensitized, or either) to 6 allergens at ages 6, 12, and 24 months. Wheeze and eczema were recorded 18 times during the first 2 years. Current wheeze was recorded at age 12 years. Adjusted associations were evaluated by multiple logistic regression.

RESULTS

A positive SPT to house dust mite (HDM) at age 1 or 2 years predicted wheeze at age 12 years (adjusted odds ratio: 1 year, 3.31 [95% CI 1.59-6.91]; 2 years, 6.37 [95% CI, 3.48-11.66]). Among wheezy 1-year-olds, those who were HDM sensitized had a 75% (95% CI, 51% to 91%) probability of wheeze at age 12 years compared with a 36% (95% CI, 23% to 50%) probability among those not sensitized. Among eczematous 1-year-olds, those who were HDM sensitized had a 67% (95% CI, 45% to 84%) probability of wheeze at age 12 years compared with a 35% (95% CI, 25% to 45%) probability among those not sensitized. Among 1-year-old children with both eczema and wheeze, the probability of wheeze at age 12 years was 64% (95% CI, 35% to 87%) if HDM sensitized and 50% (95% CI, 26% to 74%) if not.

CONCLUSION

HDM sensitization at age 1 or 2 years in wheezing and eczematous children at increased familial allergy risk predicts asthma and may inform management of these high-risk groups.

Authors+Show Affiliations

Centre for MEGA Epidemiology, University of Melbourne, Melbourne, Australia. clodge@unimelb.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21820717

Citation

Lodge, Caroline J., et al. "House Dust Mite Sensitization in Toddlers Predicts Current Wheeze at Age 12 Years." The Journal of Allergy and Clinical Immunology, vol. 128, no. 4, 2011, pp. 782-788.e9.
Lodge CJ, Lowe AJ, Gurrin LC, et al. House dust mite sensitization in toddlers predicts current wheeze at age 12 years. J Allergy Clin Immunol. 2011;128(4):782-788.e9.
Lodge, C. J., Lowe, A. J., Gurrin, L. C., Hill, D. J., Hosking, C. S., Khalafzai, R. U., Hopper, J. L., Matheson, M. C., Abramson, M. J., Allen, K. J., & Dharmage, S. C. (2011). House dust mite sensitization in toddlers predicts current wheeze at age 12 years. The Journal of Allergy and Clinical Immunology, 128(4), 782-e9. https://doi.org/10.1016/j.jaci.2011.06.038
Lodge CJ, et al. House Dust Mite Sensitization in Toddlers Predicts Current Wheeze at Age 12 Years. J Allergy Clin Immunol. 2011;128(4):782-788.e9. PubMed PMID: 21820717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - House dust mite sensitization in toddlers predicts current wheeze at age 12 years. AU - Lodge,Caroline J, AU - Lowe,Adrian J, AU - Gurrin,Lyle C, AU - Hill,David J, AU - Hosking,Clifford S, AU - Khalafzai,Rida U, AU - Hopper,John L, AU - Matheson,Melanie C, AU - Abramson,Michael J, AU - Allen,Katrina J, AU - Dharmage,Shyamali C, Y1 - 2011/08/06/ PY - 2010/12/14/received PY - 2011/06/10/revised PY - 2011/06/13/accepted PY - 2011/8/9/entrez PY - 2011/8/9/pubmed PY - 2011/12/13/medline SP - 782 EP - 788.e9 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 128 IS - 4 N2 - BACKGROUND: Identification of children at risk of developing asthma provides a window of opportunity for risk-reducing interventions. Allergen sensitization might identify high-risk children. OBJECTIVE: We sought to determine whether skin prick tests (SPTs) to individual allergens up to age 2 years predict wheeze at age 12 years. METHODS: In a birth cohort of 620 children oversampled for familial allergy, sensitization was assessed by using SPTs (monosensitized, polysensitized, or either) to 6 allergens at ages 6, 12, and 24 months. Wheeze and eczema were recorded 18 times during the first 2 years. Current wheeze was recorded at age 12 years. Adjusted associations were evaluated by multiple logistic regression. RESULTS: A positive SPT to house dust mite (HDM) at age 1 or 2 years predicted wheeze at age 12 years (adjusted odds ratio: 1 year, 3.31 [95% CI 1.59-6.91]; 2 years, 6.37 [95% CI, 3.48-11.66]). Among wheezy 1-year-olds, those who were HDM sensitized had a 75% (95% CI, 51% to 91%) probability of wheeze at age 12 years compared with a 36% (95% CI, 23% to 50%) probability among those not sensitized. Among eczematous 1-year-olds, those who were HDM sensitized had a 67% (95% CI, 45% to 84%) probability of wheeze at age 12 years compared with a 35% (95% CI, 25% to 45%) probability among those not sensitized. Among 1-year-old children with both eczema and wheeze, the probability of wheeze at age 12 years was 64% (95% CI, 35% to 87%) if HDM sensitized and 50% (95% CI, 26% to 74%) if not. CONCLUSION: HDM sensitization at age 1 or 2 years in wheezing and eczematous children at increased familial allergy risk predicts asthma and may inform management of these high-risk groups. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/21820717/House_dust_mite_sensitization_in_toddlers_predicts_current_wheeze_at_age_12_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(11)01060-8 DB - PRIME DP - Unbound Medicine ER -