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[Membranous nephropathy with nephrotic syndrome developed after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia].
Rinsho Ketsueki. 2011 Jul; 52(7):556-62.RK

Abstract

A 38-year-old man was diagnosed with acute lymphoblastic leukemia. We performed myeloablative bone marrow transplantation from an unrelated donor during the patient's first complete remission. After engraftment, he developed acute graft-versus-host disease involving the gastrointestinal tract on day 32. Steroids and mycophenolate mofetil were initiated from day 39. His symptoms improved and the dose of immunosuppressants was tapered and then discontinued on day 421. On day 491, he developed nephrotic syndrome (NS). Based on renal biopsy, membranous nephropathy was diagnosed. There were no apparent symptoms or abnormal laboratory data suggestive of chronic graft-versus-host disease (cGVHD). Steroid therapy was initiated from day 518 and proteinuria improved significantly. NS is very rare following allogeneic hematopoietic stem cell transplantation (allo-HSCT). When there is no concomitant cGVHD, as in this case, allo-HSCT-associated NS is difficult to distinguish from idiopathic NS.

Authors+Show Affiliations

Department of Hematology, Graduate School of Medicine, Osaka City University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article
Review

Language

jpn

PubMed ID

21821990

Citation

Aimoto, Mizuki, et al. "[Membranous Nephropathy With Nephrotic Syndrome Developed After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Lymphoblastic Leukemia]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 52, no. 7, 2011, pp. 556-62.
Aimoto M, Yamane T, Ichii M, et al. [Membranous nephropathy with nephrotic syndrome developed after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia]. Rinsho Ketsueki. 2011;52(7):556-62.
Aimoto, M., Yamane, T., Ichii, M., Mori, K., Moriguchi-Aimoto, R., Wada-Inoue, E., Koh, H., Nakane, T., Takeoka, Y., Akahori-Nakamae, M., Nishiki-Kosaka, S., Terada, Y., Nakamae, H., Koh, K. R., Nakao, T., Ohsawa, M., Wakasa, K., Ishimura, E., Inaba, M., & Hino, M. (2011). [Membranous nephropathy with nephrotic syndrome developed after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 52(7), 556-62.
Aimoto M, et al. [Membranous Nephropathy With Nephrotic Syndrome Developed After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Lymphoblastic Leukemia]. Rinsho Ketsueki. 2011;52(7):556-62. PubMed PMID: 21821990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Membranous nephropathy with nephrotic syndrome developed after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia]. AU - Aimoto,Mizuki, AU - Yamane,Takahisa, AU - Ichii,Mitsuru, AU - Mori,Katsuhito, AU - Moriguchi-Aimoto,Ran, AU - Wada-Inoue,Eri, AU - Koh,Hideo, AU - Nakane,Takahiko, AU - Takeoka,Yasunobu, AU - Akahori-Nakamae,Mika, AU - Nishiki-Kosaka,Saori, AU - Terada,Yoshiki, AU - Nakamae,Hirohisa, AU - Koh,Ki-Ryang, AU - Nakao,Takafumi, AU - Ohsawa,Masahiko, AU - Wakasa,Kenichi, AU - Ishimura,Eiji, AU - Inaba,Masaaki, AU - Hino,Masayuki, PY - 2011/8/9/entrez PY - 2011/8/9/pubmed PY - 2011/10/26/medline SP - 556 EP - 62 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 52 IS - 7 N2 - A 38-year-old man was diagnosed with acute lymphoblastic leukemia. We performed myeloablative bone marrow transplantation from an unrelated donor during the patient's first complete remission. After engraftment, he developed acute graft-versus-host disease involving the gastrointestinal tract on day 32. Steroids and mycophenolate mofetil were initiated from day 39. His symptoms improved and the dose of immunosuppressants was tapered and then discontinued on day 421. On day 491, he developed nephrotic syndrome (NS). Based on renal biopsy, membranous nephropathy was diagnosed. There were no apparent symptoms or abnormal laboratory data suggestive of chronic graft-versus-host disease (cGVHD). Steroid therapy was initiated from day 518 and proteinuria improved significantly. NS is very rare following allogeneic hematopoietic stem cell transplantation (allo-HSCT). When there is no concomitant cGVHD, as in this case, allo-HSCT-associated NS is difficult to distinguish from idiopathic NS. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/21821990/[Membranous_nephropathy_with_nephrotic_syndrome_developed_after_allogeneic_hematopoietic_stem_cell_transplantation_for_acute_lymphoblastic_leukemia]_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/rinketsu/52.556?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -