Tags

Type your tag names separated by a space and hit enter

Comparing incident diabetes as defined by fasting plasma glucose or by HbA(1c). The AusDiab, Inter99 and DESIR studies.
Diabet Med. 2011 Nov; 28(11):1311-8.DM

Abstract

AIM

We examined the ability of fasting plasma glucose and HbA(1c) to predict 5-year incident diabetes for an Australian cohort and a Danish cohort and 6-year incident diabetes for a French cohort, as defined by the corresponding criteria.

METHODS

We studied 6025 men and women from AusDiab (Australian), 4703 from Inter99 (Danish) and 3784 from DESIR (French), not treated for diabetes and with fasting plasma glucose < 7.0 mmol/l and HbA(1c) < 48 mmol/mol (6.5%) at inclusion. Diabetes was defined as fasting plasma glucose ≥ 7.0 mmol/l and/or treatment for diabetes or as HbA(1c) ≥ 48 mmol/mol (6.5%) and/or treatment for diabetes.

RESULTS

For AusDiab, incident fasting plasma glucose-defined diabetes was more frequent than HbA(1c) -defined diabetes (P(McNemar)<0.0001), the reverse applied to Inter99 (P(McNemar) < 0.007) and for DESIR there was no difference (P(McNema)=0.17). Less than one third of the incident cases were detected by both criteria. Logistic regression models showed that baseline fasting plasma glucose and baseline HbA(1c) predicted incident diabetes defined by the corresponding criteria. The standardized odds ratios (95% confidence interval) for HbA(1c) were a little higher than for fasting plasma glucose, but not significantly so. They were respectively, 5.0 (4.1-6.1) and 4.1 (3.5-4.9) for AusDiab, 5.0 (3.6-6.8) and 4.8 (3.6-6.3) for Inter99, 4.8 (3.6-6.5) and 4.6 (3.6-5.9) for DESIR.

CONCLUSIONS

Fasting plasma glucose and HbA(1c) are good predictors of incident diabetes defined by the corresponding criteria. Despite Diabetes Control and Complications Trial-alignment of the three HbA(1c) assays, there was a large difference in the HbA(1c) distributions between these studies, conducted some 10 years ago. Thus, it is difficult to compare absolute values of diabetes prevalence and incidence based on HbA(1c) measurements from that time.

Authors+Show Affiliations

Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Diseases over the Lifecourse, Villejuif Université Paris Sud, UMRS 1018, Villejuif, France. soraya.soulimane@inserm.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21824186

Citation

Soulimane, S, et al. "Comparing Incident Diabetes as Defined By Fasting Plasma Glucose or By HbA(1c). the AusDiab, Inter99 and DESIR Studies." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 28, no. 11, 2011, pp. 1311-8.
Soulimane S, Simon D, Shaw JE, et al. Comparing incident diabetes as defined by fasting plasma glucose or by HbA(1c). The AusDiab, Inter99 and DESIR studies. Diabet Med. 2011;28(11):1311-8.
Soulimane, S., Simon, D., Shaw, J. E., Zimmet, P. Z., Vol, S., Vistisen, D., Magliano, D. J., Borch-Johnsen, K., & Balkau, B. (2011). Comparing incident diabetes as defined by fasting plasma glucose or by HbA(1c). The AusDiab, Inter99 and DESIR studies. Diabetic Medicine : a Journal of the British Diabetic Association, 28(11), 1311-8. https://doi.org/10.1111/j.1464-5491.2011.03403.x
Soulimane S, et al. Comparing Incident Diabetes as Defined By Fasting Plasma Glucose or By HbA(1c). the AusDiab, Inter99 and DESIR Studies. Diabet Med. 2011;28(11):1311-8. PubMed PMID: 21824186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparing incident diabetes as defined by fasting plasma glucose or by HbA(1c). The AusDiab, Inter99 and DESIR studies. AU - Soulimane,S, AU - Simon,D, AU - Shaw,J E, AU - Zimmet,P Z, AU - Vol,S, AU - Vistisen,D, AU - Magliano,D J, AU - Borch-Johnsen,K, AU - Balkau,B, PY - 2011/8/10/entrez PY - 2011/8/10/pubmed PY - 2012/1/4/medline SP - 1311 EP - 8 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 28 IS - 11 N2 - AIM: We examined the ability of fasting plasma glucose and HbA(1c) to predict 5-year incident diabetes for an Australian cohort and a Danish cohort and 6-year incident diabetes for a French cohort, as defined by the corresponding criteria. METHODS: We studied 6025 men and women from AusDiab (Australian), 4703 from Inter99 (Danish) and 3784 from DESIR (French), not treated for diabetes and with fasting plasma glucose < 7.0 mmol/l and HbA(1c) < 48 mmol/mol (6.5%) at inclusion. Diabetes was defined as fasting plasma glucose ≥ 7.0 mmol/l and/or treatment for diabetes or as HbA(1c) ≥ 48 mmol/mol (6.5%) and/or treatment for diabetes. RESULTS: For AusDiab, incident fasting plasma glucose-defined diabetes was more frequent than HbA(1c) -defined diabetes (P(McNemar)<0.0001), the reverse applied to Inter99 (P(McNemar) < 0.007) and for DESIR there was no difference (P(McNema)=0.17). Less than one third of the incident cases were detected by both criteria. Logistic regression models showed that baseline fasting plasma glucose and baseline HbA(1c) predicted incident diabetes defined by the corresponding criteria. The standardized odds ratios (95% confidence interval) for HbA(1c) were a little higher than for fasting plasma glucose, but not significantly so. They were respectively, 5.0 (4.1-6.1) and 4.1 (3.5-4.9) for AusDiab, 5.0 (3.6-6.8) and 4.8 (3.6-6.3) for Inter99, 4.8 (3.6-6.5) and 4.6 (3.6-5.9) for DESIR. CONCLUSIONS: Fasting plasma glucose and HbA(1c) are good predictors of incident diabetes defined by the corresponding criteria. Despite Diabetes Control and Complications Trial-alignment of the three HbA(1c) assays, there was a large difference in the HbA(1c) distributions between these studies, conducted some 10 years ago. Thus, it is difficult to compare absolute values of diabetes prevalence and incidence based on HbA(1c) measurements from that time. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/21824186/Comparing_incident_diabetes_as_defined_by_fasting_plasma_glucose_or_by_HbA_1c___The_AusDiab_Inter99_and_DESIR_studies_ DB - PRIME DP - Unbound Medicine ER -