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Prescription patterns of Chinese herbal products for menopausal syndrome: analysis of a nationwide prescription database.
J Ethnopharmacol. 2011 Oct 11; 137(3):1261-6.JE

Abstract

ETHNO-PHARMACOLOGICAL RELEVANCE: Chinese herbal products (CHP) are commonly used for menopausal syndrome in traditional Chinese medicine (TCM).

AIM OF THE STUDY

Because menopausal syndrome is a common issue among women worldwide, this study analyzed the prescription patterns and frequencies of CHP in relieving menopausal syndrome in Taiwan.

MATERIALS AND METHODS

Prescriptions of CHP for menopausal syndrome were obtained from the nationwide prescription database (National Health Insurance Research Database) of Taiwan. Every prescription with a leading diagnosis of menopausal syndrome made in the year 2002 for women out-patients aged 45-55 years was analyzed. Descriptive statistics and data mining method (association rule mining) were applied to the pattern of co-prescription.

RESULTS

A total of 54456 prescriptions were made for 15486 subjects in clinical visits. Salvia miltiorrhiza and Dan-zhi-xiao-yao-san were the most commonly prescribed single herb (SH) and herbal formula (HF), respectively. For combinations of two CHP, Salvia miltiorrhiza with Dan-zhi-xiao-yao-san, Zhi-bai-di-huang-wan with Dan-zhi-xiao-yao-san, and Ligustrum lucidum with Eclipta prostrata were the most frequently co-prescribed CHP couplets as SH-HF, HF-HF, and SH-SH, respectively. The most commonly used combination of three CHP was Eclipta prostrata with Ligustrum lucidum and Dan-zhi-xiao-yao-san. The core formula for menopausal syndrome was Dan-zhi-xiao-yao-san.

CONCLUSIONS

Combinations of CHP are widely used for menopausal syndrome. Data mining analysis demonstrates the core formula and the commonly combined CHP in prescriptions. Further studies are needed to evaluate their efficacy for menopausal syndrome.

Authors+Show Affiliations

Division of Internal Chinese Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21824510

Citation

Chen, Hsing-Yu, et al. "Prescription Patterns of Chinese Herbal Products for Menopausal Syndrome: Analysis of a Nationwide Prescription Database." Journal of Ethnopharmacology, vol. 137, no. 3, 2011, pp. 1261-6.
Chen HY, Lin YH, Wu JC, et al. Prescription patterns of Chinese herbal products for menopausal syndrome: analysis of a nationwide prescription database. J Ethnopharmacol. 2011;137(3):1261-6.
Chen, H. Y., Lin, Y. H., Wu, J. C., Chen, Y. C., Yang, S. H., Chen, J. L., & Chen, T. J. (2011). Prescription patterns of Chinese herbal products for menopausal syndrome: analysis of a nationwide prescription database. Journal of Ethnopharmacology, 137(3), 1261-6. https://doi.org/10.1016/j.jep.2011.07.053
Chen HY, et al. Prescription Patterns of Chinese Herbal Products for Menopausal Syndrome: Analysis of a Nationwide Prescription Database. J Ethnopharmacol. 2011 Oct 11;137(3):1261-6. PubMed PMID: 21824510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prescription patterns of Chinese herbal products for menopausal syndrome: analysis of a nationwide prescription database. AU - Chen,Hsing-Yu, AU - Lin,Yi-Hsuan, AU - Wu,Jau-Ching, AU - Chen,Yu-Chun, AU - Yang,Sien-Hung, AU - Chen,Jiun-Liang, AU - Chen,Tzeng-Ji, Y1 - 2011/08/02/ PY - 2011/04/30/received PY - 2011/06/21/revised PY - 2011/07/24/accepted PY - 2011/8/10/entrez PY - 2011/8/10/pubmed PY - 2012/2/15/medline SP - 1261 EP - 6 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 3 N2 - UNLABELLED: ETHNO-PHARMACOLOGICAL RELEVANCE: Chinese herbal products (CHP) are commonly used for menopausal syndrome in traditional Chinese medicine (TCM). AIM OF THE STUDY: Because menopausal syndrome is a common issue among women worldwide, this study analyzed the prescription patterns and frequencies of CHP in relieving menopausal syndrome in Taiwan. MATERIALS AND METHODS: Prescriptions of CHP for menopausal syndrome were obtained from the nationwide prescription database (National Health Insurance Research Database) of Taiwan. Every prescription with a leading diagnosis of menopausal syndrome made in the year 2002 for women out-patients aged 45-55 years was analyzed. Descriptive statistics and data mining method (association rule mining) were applied to the pattern of co-prescription. RESULTS: A total of 54456 prescriptions were made for 15486 subjects in clinical visits. Salvia miltiorrhiza and Dan-zhi-xiao-yao-san were the most commonly prescribed single herb (SH) and herbal formula (HF), respectively. For combinations of two CHP, Salvia miltiorrhiza with Dan-zhi-xiao-yao-san, Zhi-bai-di-huang-wan with Dan-zhi-xiao-yao-san, and Ligustrum lucidum with Eclipta prostrata were the most frequently co-prescribed CHP couplets as SH-HF, HF-HF, and SH-SH, respectively. The most commonly used combination of three CHP was Eclipta prostrata with Ligustrum lucidum and Dan-zhi-xiao-yao-san. The core formula for menopausal syndrome was Dan-zhi-xiao-yao-san. CONCLUSIONS: Combinations of CHP are widely used for menopausal syndrome. Data mining analysis demonstrates the core formula and the commonly combined CHP in prescriptions. Further studies are needed to evaluate their efficacy for menopausal syndrome. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21824510/Prescription_patterns_of_Chinese_herbal_products_for_menopausal_syndrome:_analysis_of_a_nationwide_prescription_database_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00529-0 DB - PRIME DP - Unbound Medicine ER -